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Cartilage - Europe PMC

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Last Updated: 10 September 2022

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Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage.

The introduction of sustained-release drug delivery systems for OA may be an effective way to prevent rapid drug clearance and extend the half-life of a drug in the joint cavity. This paper gives an overview of joint structures in healthy and pathological conditions, introduces the introduction of sustained-release DDSs and the permeable DDSs, and discusses the optimal design of permeable DDSs for OA therapy. We hope that the results of this review will encourage the development of new OA drugs in the future.

Source link: https://europepmc.org/article/MED/35261301


Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment.

Firstly, CA integrated nanoreservoirs were manufactured based on ionic conjugation between CA and cationic hydrophobic surface modifier octadecylamine, and were further refined with CHS to produce CHS-CA-NRs. Compared to passive targeted CA-NRs, active CHS-CA-NRs demonstrated higher fluorescence signals in close proximity to and inside chondrocytes, which lasted for up to 21 days. CHS-CA-NRs' OA repair improved OA repair, showing a superior efficacy for articular cartilage targeting CHS, which could be a major step forward for OA therapy.

Source link: https://europepmc.org/article/MED/35188017


Carboxymethyl chitosan-assisted MnOx nanoparticles: Synthesis, characterization, detection and cartilage repair in early osteoarthritis

Although early detection and repair of cartilage lesions are essential in osteoarthritis treatment, they are also difficult because neither clinically administered drugs nor magnetic resonance contrast agents can identify and repair simultaneously, although early detection and repair are critical in osteoarthritis treatment. The WY-CMC-MnOu2093 NPs with their ultrasmall size and cartilage-targeting capabilities aided in a dramatic MR imaging quality of cartilage lesions relative to non-cartilage-targeting NPs. In addition, WY-CMC-MnOu2093 stimulated chondrogenesis in mesenchymal stem cells, thereby improving OA therapy by improved cartilage regeneration following intraarticularly injection in destabilization of medial meniscus rat models.

Source link: https://europepmc.org/article/MED/IND607820939


Osteophytes mediate the associations between cartilage morphology and changes in knee symptoms in patients with knee osteoarthritis.

To see if osteophytes influenced knee pains, cartilage defects and cartilage volume changes with rises in knee pains. Both at baseline and follow-up were used to assess knee pains at both baseline and follow-up. After adjustment for age, sex, body mass index, and intervention, Cartilage defects were strongly associated with decrease in total knee pain, change in overweight-bearing pain, and change in non-weight-bearing pain, and change in non-weight-bearing pain after evaluation for age, sex, body mass index, and intervention. Tibiofemoral and patellar osteophyte mediated the connection of cartilage defects with knee pain relief and elevation of weight bearing pain, as well as change in total knee pain and waist measurement, as well as changes in weight bearing pain and dysfunction. Change in knee pains was not influenced by both cartilage defects and cartilage volume. The most significant associations between cartilage morphology and knee pain improvements were indirect and partly mediated by osteophytes.

Source link: https://europepmc.org/article/MED/36076236


Implementation of Photosensitive, Injectable, Interpenetrating, and Kartogenin-Modified GELMA/PEDGA Biomimetic Scaffolds to Restore Cartilage Integrity in a Full-Thickness Osteochondral Defect Model.

Tissue engineering technology has the ability to repair cartilage defects and directs current research development. For success osteochondral repair, it is recommended that biomaterials that meet the requirements of both bone and cartilage layers be enhanced spatial control. In situ UV light curing was used to virtually connect the defect repair tissue to the surrounding cartilage tissue once the hydrogel complex was introduced into the osteochondral defect. Throbbing cartilage repair can be aided by the small molecule active substance kartogenin. We encapsulated KGN in biomimetic scaffolds so that, as the scaffold degrades, scaffold-loaded KGN was gradually released to release endogenous mesenchymal stem cells to home and differentiate into chondrocytes to repair damaged cartilage tissue. Our experiments have shown that, relative to the control group, GELMA/PEGDA + KGN repaired cartilage damage and restored cartilage to hyaline cartilage.

Source link: https://europepmc.org/article/MED/36074133


Complications Associated with Autologous Costal Cartilage Used in Rhinoplasty: An Updated Meta-Analysis.

Objection Objective With newly published literature, it's difficult to assess the risks involved autologous costal cartilage as grafts in rhinoplasty objectively and systematically. The incidence of donor-site morbidities was 2. 08%, and pneumothorax was 0%. When complications at the recipient site did not include revision surgery, the recipient website did not have revision surgery, 1. 4 percent at the donor site, and 15. 1 percent overall, the recipient site had 9. 0 percent. Warping was the most typical complication after rhinoplasty with autologous costal cartilage, according to a researcher. In these years, the revision after rhinoplasty using autologous costal cartilage was upped. After rhinoplasty using autologous rib cartilage, the complication rate increased after donor-site complications increased by 22%. The authorship of each paper must be based on evidence at any point in this journal. iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii The journal requires that authors assign a degree of credibility to each article.

Source link: https://europepmc.org/article/MED/36071242


Anatomy of the Nasal Latero-lateral Cartilage Articulation: A Micro-MRI Study in Human Specimens.

Eight LLJs could be examined, with four types of junctions: hook-shaped cephalic boundary of the LLC, hook-shaped caudal border of the ULC, hook-shaped caudal border of the LLC, and linear cephalic boundary of the LLC lateral crus, hook-shaped cephalic border of the LLC lateral crus, with clinging or not clinging tethering based on a loop-shaped border of the LLC Conclusion: In only 1/8 cases on micro-MRI images, the classical scroll articulation of the LLJ has been present in the LLJ's traditional scroll articulation. In some patients and not in others, the LLJ's anatomy could explain the surgical difficulty in raising the tip of the nose.

Source link: https://europepmc.org/article/PPR/PPR541169


Articular cartilage delamination at eight years following cellular-based repair procedures: a case reports.

Two cases of late cartilage delamination in two young adults following two new autologous cell-based techniques for cartilage restoration: 1. It's likely that regardless of the process or time since the surgery, a graft failure could occur at some level, causing delamination of a previously asymptomatic cartilage transplant graft and a painful event with long-term follow-up.

Source link: https://europepmc.org/article/MED/36069954


Hearing Outcomes of a New Cartilage Conduction Device vs Bone Conduction Devices.

Objectivities: To compare the audiometric results of a new cartilage conduction hearing device with traditional bone conduction hearing devices, a new cartilage conduction hearing device was used. Study design of a clinical trial and crossover study. Sixteen adults with congenital aural atrophy or overfilled ear canals who had previously underwent BCD implantation were given a CCD. The mean pretreatment 4-frequency pure tone average was 81 dB. The mean was 54 and 49 dB, respectively, and the average aided pure tone averages for the BCD and CCD were 27 and 32 dB, with the BCD and CCD being 27 and 32 dB. Mean AzBio scores were 90, 77%, and 52% when isolating the BCD ear, and 90%, 73%, and 41% when isolating the CCD ear. Conclusion Pure tone audiometric results with the BCD give a marginal edge over the CCD, with the main difference being primarily due to high-frequency responses.

Source link: https://europepmc.org/article/MED/36066979

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions