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Cartilage - Astrophysics Data System

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Last Updated: 10 January 2023

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PPARα−ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis

In cartilages of an OA patient and an OA-induced animal, a greater concentration of ACOT12 was found. Using RNA-guided endonuclease, we established Acot12 knockout mice to determine the role and association of ACOT12 in the OA pathogenesis. Moreover, conversion of ACOT12 into human OA chondrocytes and OA-induced mouse cartilage effectively rescued OA's pathophysiological characteristics by limiting DNL. ACOT12 is a novel regulatory factor in cartilage homeostasis that maintains cartilage homeostasis, according to our report, and targeting ACOT12 may lead to the development of a new therapeutic approach for OA.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatCo..13....3P/abstract


Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing

Osteoclasts generated by circulating monocyte degrade bone fusion are degrading bone, whereas the identity of the cells responsible for cartilage resorption remains a long-running and controversial question. The degradation and chondrocyte phagocytosis of matrix degradation and chondrocyte phagocytosis are mediated by fatty acid binding protein 5-expressing cells in this study. Consistent with the loss of growth, septoclasts disappear in adult and ageing bone, but re-emerge in association with growing vessels during fracture healing.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatCo..13..571S/abstract


Change in knee cartilage components in stroke patients with genu recurvatum analysed by zero TE MR imaging

The ratios of the hemiplegic limb vs. the nonhemiplegic limb in patients were strikingly different when comparing the lateral horn and posterior horn of the lateral meniscus. As the genu recurvatum rises, stroke patients with hemiplegia can have changes in knee cartilage's moisture content, and knee cartilage changes are more apparent.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..12.3751L/abstract


Inhibition of SYK and cSrc kinases can protect bone and cartilage in preclinical models of osteoarthritis and rheumatoid arthritis

It is well known that csrc kinase plays a role in bone and cartilage repair, and SYK kinase is correlated with the inflammatory component. Among other in vitro and in vivo arthritis models, the objective of this research was to determine the mechanism of action and effectiveness of a small molecule multikinase inhibitor MT-SYK-03 targeting SYK and cSrc kinases among others. With IC 50 of 14. 2 and 23 nM respectively, MT-SYK-03 inhibited csrc and SYK-03 inhibited csrc and SYK. In vivo, MT-SYK-03 showed preferential distribution to joint and bone tissue and revealed disease-modifying activity by halving the extent of cartilage erosion in a rat SIA model and raising the pain threshold in a rat MIA model. In a monotherapy regiment and in combination with methotrexate in murine and rat CIA models, an immune-mediated inflammation in rat AIA models was reduced; an immune-mediated inflammation was found.

Source link: https://ui.adsabs.harvard.edu/abs/2021NatSR..1123120N/abstract


Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints

We collected femoral heads from hip osteoarthritis and femoral neck fracture patients in this series. Mapping of the trabecular bone microstructure in OA patients with low CLS revealed a trabecular network resembling non-OA patients, although clear differences were evident in subchondral plate architecture. In the tribcular bone, the deterioration of OA was regionally related to lower BV/TV, TMD, and thickness, as well as increased BS/BV and porosity, and increased BS/BV and porosity; and with thinner, less separated trabecular cartilage with increased TMD and BV/BV in the trabecular bone. Our results show that impairment of subchondral bone microstructure in early stages of OA is more apparent in the cortical plate and that morphological characterisation of the femoral head bone microstructure may facilitate earlier OA diagnosis and monitoring of progression.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..12.6694A/abstract


Anisotropic hydrogel fabricated by controlled diffusion as a bio-scaffold for the regeneration of cartilage injury

The next generation of tissue engineering is based on heterogeneous structures that can replicate the body's original biological complexity. Managed manufacture of anisotropic materials has become a hotspot in biomaterials science. Since the next generation of tissue engineering, especially biomaterials, is based on the application of heterogeneous structures that can mimic the body's original biological complexity, controlled manufacturing of anisotropic materials has become a hotspot in materials science, especially biomaterials. The new fabric manufacturing process of producing anisotropic materials for related tissue engineering calls for costly and highly specialized equipment, and not every conventional approach can be applied to anisotropic materials for corresponding tissue engineering. Anisotropic materials can be applied to a problem in tissue engineering: cartilage repair: cartilage injury repair. The diffusion of two solutions can be limited by a lack of densities.

Source link: https://ui.adsabs.harvard.edu/abs/2022RSCAd..1228254Y/abstract


Optimization of spin-lock times for T 1ρ mapping of human knee cartilage with bi- and stretched-exponential models

Two optimization criteria based on Cram's R-Rao Bounds are compared against each other and with non-optimized targets for T 1-u03c1 mapping, using synthetic data, model phantoms, and in-vivo knee cartilage. In all cases that were tested, the optimized spin-lock time schedules produced increased success over the non-optimized schedules. Optimized schedules can be obtained with greater precision and reduced acquisition times by 16. 5 minutes for the bi-exponential model, and 6. 6 minutes for the stretched-exponential model, according to the simulations. The optimized TSL schedules can be used to improve parameter maps' quality or reduce scan time.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1216829D/abstract


Integration of 3D genome topology and local chromatin features uncovers enhancers underlying craniofacial-specific cartilage defects

The Pierre Robin sequence is characterized by the undersized lower jaw due to the disruption of a noncoding region distal from the human SOX9 gene. Even after decommissioning CNCC enhancers, we can now show that the PRS area also strongly controls Sox9 in CNCC-derived Meckel's cartilage, but not in limb cartilages. The presence of such a MC-specific regulatory effect in instructing enhancer use correlates with the MC-specific chromatin contacts between the PRS area and Sox9, underscoring the importance of chromatin topology in assisting increasing improver usage. The differentiation between enhancers used in cartilages from various body locations is shown by a lineage-dependent 3D chromatin topology.

Source link: https://ui.adsabs.harvard.edu/abs/2022SciA....8O3648C/abstract


Human synovial mesenchymal stem cells show time-dependent morphological changes and increased adhesion to degenerated porcine cartilage

The objectives of the present study were to establish whether synovial MSCs adhere to degenerated cartilage, the time line of that adhesion, and MSCs may have undergone morphological changes during the adhesion process. The MSCs that adhered within ten s of placement and time up to 24 h had a high incidence of microspikes, whereas those that adhered after 1 h had the pseudopodia.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1216619T/abstract


Modulation of the long non-coding RNA Mir155hg by high, but not moderate, hydrostatic pressure in cartilage precursor cells

Osteoarthritis, the most common joint disease in older adults, is characterized by declining cartilage matrix gene expression and the increased expression of genes involved in protein degradation, apoptosis, and inflammation. Gene expression changes in chondrocyte precursor cells similar to those that are seen in OA were demonstrated by high pressure above 20 MPa. As the micro-RNA miR-155hg gene expression in OA chondrocytes has increased, we investigated the effects of high pressure on the expression of the miR-155 host gene Mir155hg. The chondrocyte progenitor cell line ATDC5 was pressurized under hydrostatic pressure up to 25 MPa; or the resulting micro-RNAs were measured; pharmacological inhibitors were used to determine the signaling pathways involved in the regulation of Mir155hg.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1775682M/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions