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Carpal Tunnel Syndrome - MedlinePlus Genetics

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Last Updated: 10 June 2022

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Carpal tunnel syndrome

"Carpal tunnel syndrome is a disorder caused by nerve blockade "that causes pain and numbness, often in the wrist and hand. " Although carpal tunnel syndrome can occur at any age, it most commonly affects people between the ages of 40 to 60. Since only one hand is affected, it is most often the hand used for writing. The pain or paresthesia is usually felt in the wrist, the palm, and the first four fingers of the hand in carpal tunnel syndrome. Carpal tunnel syndrome can be caused by certain activities that stretch or extend the wrist, such as driving, typing, or holding a phone. People with carpal tunnel syndrome can suffer muscle and nerve wasting in the affected hand as well as a decreased ability to detect sensations, which can be mistaken for an improvement of symptoms.

Source link: https://medlineplus.gov/genetics/condition/carpal-tunnel-syndrome


Hereditary neuropathy with liability to pressure palsies

"Hereditary neuropathy with responsibility for pressure palsies is a condition that affects peripheral nerves. " Typical episodes of numbness, tingling, and muscle weakness in the region of concern with the affected nerve, whether arm, hand, leg, or foot, are typical. Pressure on a single nerve can cause a pressure palsy episode, and any peripheral nerve can be affected. Carpal tunnel syndrome is characterized by numbness, tingling, and hand and fingers. An episode of nerve compression in the knee can result in a condition called foot drop, which makes walking, scaling stairs, or driving difficult or impossible. Sheeditary neuropathy with accountability to pressure palsies typically begin during childhood or early adulthood, but they can develop from childhood to late adulthood.

Source link: https://medlineplus.gov/genetics/condition/hereditary-neuropathy-with-liability-to-pressure-palsies


Transthyretin amyloidosis

"Transthyretin amyloidosis is a slowly progressive disease characterized by abnormal deposits of amyloid in the body's organs and tissues. These protein deposits most often occur in the peripheral nervous system, which is made up of nerves connecting the brain and spinal cord to muscles, and sensory cells that detect sensations such as touch, pain, warmth, and sound. Transthyretin amyloidosis is one of three primary types of transthyretin amyloidosis, which are distinguished by their signs and body systems that control. The neuropathic form of transthyretin amyloidosis mainly affects peripheral and autonomic nervous systems, resulting in peripheral neuropathy and difficulty controlling bodily functions. Some people suffer with heart and kidney disease as well. Some people with this condition of transthyretin amyloidosis have carpal tunnel syndrome, which is characterized by numbness, tingling, and hand and finger weakness. Transthyretin amyloidosis, which is mainly related to the central nervous system, is the leptomeningeal variant of transthyretin amyloidosis. Amyloidosis occurs in the leptomeninges, two thin layers of tissue that cover the brain and spinal cord in people with this condition. Eye problems in the neuropathic form may also occur. When people with leptomeningeal transthyretin amyloidosis develop eye problems, they are thought to be in oculomeningeal form. The heart is affected by transthyretin amyloidosis' cardiac manifestation. People with cardiac amyloidosis may have an abnormal heartbeat, an enlarged heart, or orthostatic hypertension. Occasionally, people with transthyretin amyloidosis have mild peripheral neuropathy.

Source link: https://medlineplus.gov/genetics/condition/transthyretin-amyloidosis


Mucopolysaccharidosis type VI

Many tissues and organs will enlarge, become inflamed or scarred, and eventually waste away, as a result of Maroteaux-Lamy syndrome, also known as Maroteaux-Lamy syndrome. Symptoms may have varying degrees of illness. People with MPS VI generally do not have any of the condition's characteristics at birth. Early childhood, children often begin to show signs and symptoms of MPS VI. In many children with MPS VI, Carpal tunnel syndrome develops, resulting in numbness, tingling, and a lack of hand and fingers. People with MPS VI may experience a narrowing of the spinal canal in the neck, which can compress and damage the spinal cord. People with MPS VI have heart valve abnormalities, which is typical. Respiratory abnormalities in this condition may include the airway narrowing, which results in frequent upper respiratory infections and short pauses in breathing during sleep. People with MPS VI may also suffer from recurrent ear infections and hearing loss. MPS VI does not influence intelligence unlike other forms of mucopolysaccharidosis. Individuals with MPS VI have varying degrees of pain and illness, as well as their general health. Individuals who are seriously affected by therapy may not live until late childhood or adolescence. Many with milder forms of the disorder live into adulthood, although their life expectancy can be reduced. People with MPS VI are likely to die from heart disease and airway obstruction, as well as airway obstruction. ".

Source link: https://medlineplus.gov/genetics/condition/mucopolysaccharidosis-type-vi


1q21.1 microduplication

"1q21. 1 microduplication is a chromosomal shift in which a small amount of genetic material on chromosome 1 is mistakenly copied. " Individuals with autism spectrum disorder may also have characteristics of autism spectrum disorder. Expressive language skills in affected individuals tend to be more impaired than receptive language skills. 1q21. 1 microduplications may also be associated with an elevated risk of attention-deficit/hyperactivity disorder and other behavioral disorders in childhood. Psychiatric disorders such as schizophrenia or mood disorders such as anxiety or depression are present in some affected individuals, mostly during adulthood. Some people with a 1q21. 1 microduplication are born with malformations of the heart, including a specific set of heart abnormalities that are described as tetralogy of Fallot. Individuals with a 1q21. 1 microduplication may also have a larger than average head size or taller than normal adult stature. Among the affected members of the same family, the chromosomal change has multiple signs and symptoms.

Source link: https://medlineplus.gov/genetics/condition/1q211-microduplication


Acromicric dysplasia

"Acromicric dysplasia is a condition characterized by short stature, short limbs, elastic joints, and characteristic facial features. " Normal newborns with acromic dysplasia are of normal size, but short stature is typical. About 4 feet, 2 inches for women and 4 feet, 5 inches for men with this disorder. The average height of adults with this disorder is about 4 feet, 2 inches for women and 4 feet, 5 inches for men. Many people with carpal tunnel syndrome suffer from numbness, tingling, and a lack of hand and fingers. In this condition, a misalignment of the hip joints can also occur. Some skeletal and joint disorders may require medical attention, but most affected individuals have no restrictions in their daily activities. Children with acromic dysplasia may have a round face, sharply defined eyebrows, long eyelashes, a bulbous nose with upturned nostrils, a long gap between the nose and upper lip, and a small mouth with thick lips.

Source link: https://medlineplus.gov/genetics/condition/acromicric-dysplasia

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions