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Carpal tunnel syndrome is the most common entrapment neuropathy and has a largely unknown underlying biology. We found 53 sequence variants at 50 loci associated with CTS in a genome-wide association study. Through various functional studies, we find that at least 22 genes mediate CTS risk and emphasize the importance of 19 CTS variants in the extracellular matrix's biology. The genetic component of the risk in bilateral/persistent/persistent cases is higher than in nonrecurrent/nonpersistent cases, according to our analysis.
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