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Carpal Tunnel - MedlinePlus Genetics

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Last Updated: 10 September 2022

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Carpal tunnel syndrome

Carpal tunnel syndrome is a disorder caused by neural function disturbances, resulting in pain and numbness, particularly in the wrist and hand. While carpal tunnel syndrome can occur at any age, it most often affects people between the ages of 40 to 60. When only one hand is affected, it is usually the hand used for writing. The pain or paresthesia is usually felt in the wrist, the palm, and the first four fingers of the hand in carpal tunnel syndrome. Carpal tunnel syndrome can be triggered by certain activities that stretch or extend the wrist, such as driving, typing, or holding a telephone. People with carpal tunnel syndrome may have muscle and nerve wasting in the affected hand as well as a decreased ability to detect sensations, which can be mistaken for an improvement of symptoms.

Source link: https://medlineplus.gov/genetics/condition/carpal-tunnel-syndrome


Hereditary neuropathy with liability to pressure palsies

Pressure palsies dermapathy is a condition that affects peripheral nerves. These activities would not normally result in sensation loss in people with the disorder. Hereditary neuropathy with ties to pressure palsies is characterized by recurrent episodes of numbness, tingling, and muscle loss in the region responsible for the affected nerve, usually an arm, hand, leg, or foot. Pressure on a single nerve causes a pressure palsy episode, and any peripheral nerve can be affected. Many people with this condition have carpal tunnel syndrome, which occurs when a nerve in the wrist is involved. The signs of hereditary neuropathy with risk to pressure palsies typically begin during adolescence or early adulthood, but they can occur anywhere from childhood to late adulthood.

Source link: https://medlineplus.gov/genetics/condition/hereditary-neuropathy-with-liability-to-pressure-palsies


Acromicric dysplasia

Acromicric dysplasia is a disorder characterized by short stature, short limbs, stiff joints, and specific facial features. Newborns with acromic dysplasia are of normal size, but short stature is the result of slowed growth over time. Adults with this condition have a height of about 4 feet, 2 inches for women and 4 foot, 5 inches for men. Affected individuals are more likely to experience carpal tunnel syndrome, which is characterized by numbness, tingling, and hand and finger weakness. In this condition, a misalignment of the hip joints can also occur. These skeletal and joint injuries may require medical attention, but most affected individuals have no restrictions in their daily activities. A round face, sharply defined eyebrows, long eyelashes, a bulbous nose with upturned nostrils, a long nose with narrow lips, and a narrow mouth with thin lips are all typical of acromic dysplasia.

Source link: https://medlineplus.gov/genetics/condition/acromicric-dysplasia


Mucopolysaccharidosis type II

Mucopolysaccharidosis type II, also known as Hunter syndrome, is a disorder that affects many areas of the body and occurs almost exclusively in males. People with MPS II tend to have thick skin that is not elastic. Some of the affected individuals also have distinctive white skin growths that look like pebbles. Most people with this disorder experience hearing loss and have recurrent ear infections. Some people with MPS II have problems with the light-sensitive tissue in the back of the eye and reduced vision. The spinal cord can be compressed and damaged by narrowing the spinal canal in the neck. MPS II also impacts the heart, and heart valve dysfunctions can be present in many people. Heart valve abnormalities can cause the heart to become larger and may eventually lead to heart disease. Children with MPS II continue to grow steadily until about age 5, but after that, their growth slows and they reach short stature. Multiple skeletal abnormalities seen on x-ray also affects the majority of people with MPS II. Although both types of cancer affect many organs and tissues as shown above, people with severe MPS II suffer from a decrease in intellectual function and a more rapid disease progression. Individuals with the severe appearance begin to develop basic life skills between the ages of 6 to 8. People with both types of MPS II are at risk of death due to heart disease and airway obstruction.

Source link: https://medlineplus.gov/genetics/condition/mucopolysaccharidosis-type-ii


Transthyretin amyloidosis

Transthyretin amyloidosis, a slowly progressing disease characterized by abnormal accumulations of a protein called amyloid in the body's organs and tissues, is a slowly progressing disease. These protein deposits most often occur in the peripheral nervous system, which is made up of nerves connecting the brain and spinal cord to muscles, and sensory cells that detect sensations such as touch, pain, heat, and sound. Transthyretin amyloidosis has three main types that can be distinguished by their signs and body systems they affect. Transthyretin amyloidosis' neuropathic form is primarily responsible for peripheral and autonomic nervous systems, resulting in peripheral neuropathy and difficulty controlling bodily functions. Some people have heart and kidney disease as well as diabetes. carpal tunnel syndrome is a syndrome that causes numbness, tingling, and a lack of hand and fingers among those with this disorder. Transthyretin amyloidosis, which is primarily related to the central nervous system, is the leptomeningeal form. Amyloidosis occurs in the leptomeninges, which are two thin layers of tissue that cover the brain and spinal cord in people with this disease. Eye problems related to those in the neuropathic variety may also occur. When people with leptomeningetal transthyretin amyloidosis have eye disease, they are likely to be in the oculomeningeal form. Transthyretin amyloidosis affects the heart. An abnormal heartbeat, enlarged heart, or orthostatic hypertension can all be present in people with cardiac amyloidosis. Occasionally, people with transthyretin amyloidosis have mild peripheral neuropathy.

Source link: https://medlineplus.gov/genetics/condition/transthyretin-amyloidosis


Mucopolysaccharidosis type VII

MPS VII's most common cases are caused by hydrops fetalis, a condition in which excess fluid builds up in the body prior to birth. Most babies with hydrops fetalis are either born or die soon after birth. People with MPS VII begin to experience signs and symptoms of the disorder early childhood. People with MPS VII may also suffer with persistent ear infections and hearing loss. In several children with MPS VII, Carpal tunnel syndrome develops, resulting in numbness, tingling, and hand and fingers weakness. People with MPS VII may experience a narrowing of the spinal canal in the neck, which may cause the neck to shrink and break the spinal cord. Individuals with MPS VII have varying life expectancies because of their severity of illness. People with MPs VII are at risk of death from heart disease and airway obstructions.

Source link: https://medlineplus.gov/genetics/condition/mucopolysaccharidosis-type-vii


Mucopolysaccharidosis type I

MPs children with MPs I often have no signs or symptoms of the disease at birth, although some have a soft out-pouching around the belly-button or lower abdomen. People with severe MPS begin to show other signs and symptoms of the disorder within the first year of life, while those with the attenuated form have less noticeable characteristics that occur later in childhood. People with MPs I often get cloudy of the eye's transparent coating, which can cause significant vision loss. Affected individuals may also suffer from hearing loss and chronic ear infections. MPS I have short stature and joint deformities that influence mobility. Multiple skeletal abnormalities seen on x-ray can be present in most people with the severe form of the disease. The spinal cord can be compressed and strained if the spinal cord is narrowed in the neck. Although both types of MPS I can influence many organs and tissues, people with serious MPS I notice a decrease in intellectual function and a more rapid disease progression. Individuals with attenuated MPS I typically live into adulthood and may or not have a shorter lifespan. Death in people with both types of MPS I is related to heart disease and airway obstruction.

Source link: https://medlineplus.gov/genetics/condition/mucopolysaccharidosis-type-i

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions