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Carpal Tunnel - DOAJ

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Last Updated: 10 January 2023

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Cutaneous expression of growth-associated protein 43 is not a compelling marker for human nerve regeneration in carpal tunnel syndrome.

In humans, GAP-43 expression has been predominantly found in skin biopsies from patients with peripheral neuropathies; in other studies, there has been a decrease in GAP-43 immunoreactive cutaneous nerve fibers, as shown in multiple studies. However, it is also unknown if cutaneous GAP-43 is a reliable indicator of human nerve regeneration. We present a cohort of 22 patients with electrodiagnostically confirmed carpal tunnel syndrome, used as a reference system for focal nerve injury and neural regeneration after decompression surgery. We investigate GAP-43 immunoreactivity and RNA expression in finger skin biopsy biopsies obtained before and 6 months after surgery relative to healthy controls. Patients with CTS have lower GAP-43 positive intra-epidermal nerve fibre density before surgery, relative to healthy controls. These findings reveal that cutaneous GAP-43 may not be a useful indicator of nerve regeneration in humans.

Source link: https://doi.org/10.1371/journal.pone.0277133


Carpal tunnel volume distribution and morphology changes with flexion-extension and radial-ulnar deviation wrist postures.

According to non-neutral wrist positions, reduced carpal tunnel volume has been found leading to decreased carpal tunnel volume, which has led to the median nerve impingement and carpal tunnel syndrome. According to a new report, CTV did not change with flexion-extension beyond U00b0, however, CTV dropped with a drastic decline between -5u00b0 and 15u00b0 deviations, a range of -5 to 15 pixels. In both FE and RUD, the aim of this research was to determine volume distribution along the length of the carpal tunnel and to quantify regional morphology changes with deviated wrist positions. With flexion and the proximal part of the tunnel, the tunnel's permeability may have reduced, contributing to localized medial nerve compression. Morphology reports also found a shift between the tunnel's proximal and distal aspects, which may have exacerbated flexion and ulnar deviation and could make it harder to stretch the median nerve.

Source link: https://doi.org/10.1371/journal.pone.0277234


Carpal tunnel syndrome caused by tophi deposited under the epineurium of the median nerve: A case report

Carpal tunnel syndrome is one of the most common peripheral neuropathy disorders that can be caused by compression of the wrist's median nerve. The median nerve compresses the median nerve, triggering CTS, which is extremely unusual in this case. Case Presentation Tophi is a publication that publishes articles about A 64-year-old man with a history of tophaceous gout who suffered with typical CTS symptoms and was admitted to our hospital. When serum uric acid levels were within normal ranges, a carpal tunnel installation and surgery to remove the gouty tophus of the right wrist were carried out. During a 1-year follow-up period, the patient recovered uneventfully, with no signs of extrinsic compression of the median nerve or CTS symptoms emanating from the carpal tunnel.

Source link: https://doi.org/10.3389/fsurg.2022.942062


Clinical Utility of Boston-CTS and Six-Item CTS Questionnaires in Carpal Tunnel Syndrome Associated with Diabetic Polyneuropathy

We enrolled patients with type 2 diabetes with signs and symptoms consistent of DPN in our prospective cross-sectional study. With nerve conduction studies for finding CTS in patients with DPN, we wanted to compare two clinical scales: the Boston Carpal Tunnel Syndrome Questionnaire and the six-item CTS symptoms scale. Patients with and without CTS were statistically different between patients with and without CTS, according to BCTQ and CTS-6's clinical report. When comparing the BCTQ questionnaire with the NCS results, we discovered an area under the curve = 0. 76 in patients with neuropathy and AUC = 0. 72 in patients without neuropathy. Both the Boston Carpal Tunnel Syndrome and CTS-6 questionnaires can be used in the diagnosis of CTS in diabetic patients with and without DPN but with moderate AUC.

Source link: https://doi.org/10.3390/diagnostics13010004


Laser Acupuncture as a Treatment Option for Carpal Tunnel Syndrome Management: a Case Series

With a total sample of 3 patients, most with tingling sensations, this research aims to determine the results of laser acupuncture using a Boston questionnaire, visual analogue scale, Tinel sign, Phalen sign, and nerve conduction parameters. The results reveal a decrease in NCS scores for three wrists, a decrease in VAS, and no significant change in Tinel and Phalen signs. Laser acupuncture can be used as a treatment option for carpal tunnel syndrome management, according to the authors.

Source link: https://doi.org/10.51507/j.jams.2022.15.3.189


Work‐relatedness of carpal tunnel syndrome: Systematic review including meta‐analysis and GRADE

Abstract Background and Aims Carpal tunnel syndrome is the most common peripheral nerve entrapment syndrome with a high incidence among workers. This comprehensive review, which also includes metau2010analyses, is designed to determine which physical work-related risk factors are correlated with carpal tunnel syndrome in people with carpal tunnel syndrome. Using the Quality in Prognosis Studies program, a bias risk was determined. Results In total, 9270 patients with CTS from a population of 1,051,707 workers were identified from 17 studies. Conclusion This systematic review of prospective cohort studies revealed a high risk of CTS among a large Strain Index, exposures beyond the Activity Level of ACGIH, increased force intensity, and high repetition revealed the highest risk of CTS. Some workers doing repetitive tasks that require both high force and high repetition also have a higher risk of developing CTS.

Source link: https://doi.org/10.1002/hsr2.888


Prevalence of carpal tunnel syndrome in patients with long-term type 2 diabetes mellitus

Patients with type 2 diabetes mellitus patients were retrospectively investigated based on the measurement of nerve conduction velocity, the incidence of CTS, and the characteristics of nerve injury. Patients with T2DM were hospitalized in Taiyuan Central Hospital between January 2018 and January 2019. These 139 T2DM patients with CTS were then divided into groups based on the nerve injury location and the injured nerve type. Sensor nerve injury was more common than that of motor nerve injury. In the right median nerve, the abnormal rate of sensory nerve conduction velocity and motor nerve conduction velocity was both higher. For T2DM patients with T2DM-induced CTS with a high incidence rate, early screening of NCV is essential. Early detection of NCV can rule CTS in the absence of medical conditions and SNI, according to this report, and it may occur earlier in long-term T2DM patients with CTS.

Source link: https://doi.org/10.1016/j.heliyon.2022.e12615


Ultrasonographic Assessment of the Safe Zone for Carpal Tunnel Intervention: A Comparison Between Healthy Individuals and Patients With Carpal Tunnel Syndrome

Objectivity: Using ultrasonography, healthy people and patients with carpal tunnel syndrome were compared to achieve transverse and longitudinal safe zones. Patients with CTS were divided into three groups based on electrodiagnostic results. We measured the distance between the median nerve and ulnar vessels to determine the transverse safe zone, as well as the distance between the distal flexor retinaculum and superficial palmar artery arch to determine the longitudinal safe zone by using ultrasound. Conclusions The transverse and longitudinal safe zones were noticeably different between participants with CTS and those without CTS. The transverse safe zone was not significantly different between the mild and severe CTS groups, although the longitudinal safe zone was not significantly different between the two groups. Conclusions Transverse and longitudinal safe zones in patients with CTS were narrower in patients with CTS than in the healthy group. Patients with mild CTS and those with severe CTS were shown to show a significant difference.

Source link: https://doi.org/10.5535/arm.22123


The Relationship Between Thyroid Dysfunctions and Symptom Severity and Functionality in Patients with Carpal Tunnel Syndrome

paraphrasedoutput:Method: This research sought to investigate the connection between thyroid dysfunctions and disease severity and functional status in patients with CTS, and was recruited according to the inclusion criteria. To determine disease severity and functionality, respectively, the Boston questionnaire-symptom severity scale and Boston questionnaire-functional status scale were used. In group 1, the mean symptom duration was 10. 64 months, u00b13. 08 months, and 24. 63 month in group 2, with 24. 06 months in group 2. In group 1 and 42. 00. 10, respectively, 7. 85 u00b15. 85, and 42. 10 in group 2 were the most significant, and the effect was longer in CTS patients with thyroid dysfunction. Therefore, the diagnosis and treatment of thyroid abnormalities in patients with CTS may be helpful in reducing symptoms.

Source link: https://doi.org/10.4274/BMB.galenos.2022.2022-05-050


Fibrosis-Associated Signaling Molecules Are Differentially Expressed in Palmar Connective Tissues of Patients with Carpal Tunnel Syndrome and Dupuytren’s Disease

Even in clinically unremarkable tissue samples from DD patients, the expression of FGFR1, FGFR2, and CTGF in the blood vessel walls and surrounding connective tissue cells differed significantly between the two groups. Profibrotic factors in the clinically intact palmar fascia of DD patients may indicate that more extensive excision is required during surgical treatment, although profibrotic causes could be potential targets for developing pharmacological therapeutic strategies against DD-associated fibrosis.

Source link: https://doi.org/10.3390/biomedicines10123214

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions