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Carpal Tunnel - Astrophysics Data System

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Last Updated: 10 January 2023

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Carpal tunnel volume distribution and morphology changes with flexion-extension and radial-ulnar deviation wrist postures

According to non-neutral wrist positions, reduced carpal tunnel volume has been found to cause decreased carpal tunnel volume leading to median nerve impingement and carpal tunnel syndrome formation. Both FE and RUD, respectively, want to measure volume distribution along the length of the carpal tunnel and identify regional morphology shifts with deviated wrist positions in both FE and RUD. With both FE and RUD, the volume inside the carpal tunnel was seen to redistribute. Localized compression of the medial nerve may have contributed to reduced volume in the distal portion of the tunnel with flexion and proximal aspect of the tunnel with ulnar deviation. Morphology reports also showed variations between the tunnel's proximal and distal elements that increased with flexion and ulnar deviation, which could have exacerbated strain on the median nerve.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1777234A/abstract


Cutaneous expression of growth-associated protein 43 is not a compelling marker for human nerve regeneration in carpal tunnel syndrome

In humans, GAP-43 has predominantly been investigated in skin biopsies from patients with peripheral neuropathies, with several studies revealing a decrease in GAP-43 immunoreactive cutaneous nerve fibers, as shown in multiple studies. However, it is also unknown if cutaneous GAP-43 is a reliable indicator of human nerve regeneration. Here, we present a cohort of 22 patients with electrodiagnostically confirmed carpal tunnel syndrome, which serves as a model system for focal nerve injury and neural regeneration after decompression surgery. In finger skin biopsy biopsies obtained before and 6 months after surgery, we investigate GAP-43 immunoreactivity and RNA expression levels in finger skin biopsies taken before and six months after surgery relative to healthy controls. Patients with CTS have lower GAP-43 positive intra-epidermal nerve fibre density before surgery than healthy controls, according to the study. These results show that cutaneous GAP-43 may not be a valid indicator of nerve regeneration in humans.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1777133C/abstract


A clinical study of thread carpal tunnel release with a newly developed thread: A retrospective pilot study

Introduction Compared to an open and endoscopic procedure, thread carpal tunnel release, ultrasound-guided transverse carpal ligament transection procedure through needle and thread, has been found to be a safe and effective method for carpal tunnel release. Compared to the commercial thread in clinical settings, this pilot study was carried out to determine the efficiency of TCTR with Smartwire-01. Physiology Methods An initiation of a 42-month course, one physiatrist's total of 22 TCTR procedures have been done on 19 patients by one physiatrist. Electromyography was used to determine carpal tunnel syndrome in accordance with established medical diagnoses. Both pain and functional capacity were shown by the TCTR thread's newly developed thread, demonstrating its effectiveness in both pain and functional ability. Conclusions According to the review, our newly developed thread is as safe and effective as the commercial thread in TCTR, and we therefore recommend a randomize controlled trial with above methodology.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1776630P/abstract


A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome

Carpal tunnel syndrome is the most common entrapment neuropathy and has a largely unknown underlying biology. Through various functional experiments, we find that at least 22 genes mediate CTS risk and highlight the presence of 19 CTS variants in the extracellular matrix's biology. According to studies, the genetic component to the risk is more prevalent in bilateral/recurrent/persistent infections than in nonrecurrent/nonpersistent cases. Our results indicate that the extracellular matrix's components play a key role in CTS' pathogenesis.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatCo..13.1598S/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions