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We investigated the effectiveness of exosomes obtained from AT2R-overexpressing bone mesenchymal stem cells in this study on the prevention of restenosis following carotid artery injury in this research. AT2R-Exo were more efficiently embedded in the injured carotid artery than EXO and Vehicle-EXO controls, according to a In vivo report. The injured carotid artery site's blood flow may be improved by AT2R-EXO therapy, which may be able to restore blood flow to the injured carotid artery site more effectively. AT2REXO prevents restenosis following a carotid artery injury, according to a later review by attenuating the injury-induced neointimal hyperplasia.
Source link: https://europepmc.org/article/MED/35900670
Background Diabetes mellitus is closely linked to both the severity of carotid disease and its sequel after revascularization. Carotid artery stenting has emerged as a viable alternative to surgical endarterectomy, but little is known about the consequences of diabetes after CAS. At 30 days post-CAS and a one-year follow-up, a prospective cohort of 1940 patients undergoing CAS in two institutions was divided into two groups, diabetics and nondiabetics, and major cerebrovascular events were analyzed, including diabetics and nondiabetics, and acute cerebrovascular events. Overall stroke/death rate in the asymptomatic patients was 2. 4%, although the restosis rate was higher in the diabetes population.
Source link: https://europepmc.org/article/MED/35860343
Purpose of this Study The aim of this research was to announce intermediate-term findings of the duplex ultrasound follow-up of carotid artery stenting done with the dual-layer stent, as compared to similar patients treated with other commercially available single-layer carotid stents. The two-layer stent implantations were compared to first-generation carotid stent implantations. Conclusions In this real-life cohort of patients undergoing carotid artery stenting, the patients treated with low-profile dual-layer micromesh stents demonstrated elevated incidences of restenosis and reinterventions compared to first-generation single-layer stents.
Source link: https://europepmc.org/article/MED/35798859
Background and purpose In-stent intimal hyperplasia may have triggered carotid artery stenting, and in many cases necessitates re-stenting. We investigated whether a new ultrasound technique is able to detect carotid artery plaques susceptible to ISR. Purpose Superb micro-vascular imaging is a new color Doppler imaging technique for determining low-speed blood flow such as neovascularization in carotid artery plaques. After 6 months of CAS, we investigated links between studies from carotid ultrasonography with SMI performed before CAS and in-stent restenosis. Patients with preoperative mean stenosis was 63%, according to North American Symptomatic Carotid Endarterectomy Trial techniques in 19 patients, the rate was 53. 3 percent. At six months after CAS reported ISR in 4 patients, none of whom had shown neovascularization on SMI, Carotid angiography occurred. Conclusions Preprocedural plaque characterization by carotid ultrasound with SMI seems to be helpful in predicting ISR at 6 months after CAS.
Source link: https://europepmc.org/article/MED/35797762
Aims To determine patients at risk of long-term restenosis, using quantitative MRI angiography, to determine patients at risk of long-term restenosis after CEA. Patients at risk of restenosis for up to ten years were identified as a result of QMRA's survey, which was used to identify patients at risk of restenosis for up to ten years. Patients with long-term restlessness were significantly higher in patients without long-term rest, both for the ipsilateral ICA and MCA, as well as those with restenosis. The ICA mean flow ratio tended to be more reliable than the MCA ratio in predicting restenosis over the long run. Conclusions The preliminary findings show that after CEA, QMRA-based mean flow increases, which may be predictive of restlessness over the long run. A Perioperative QMRA study could lead to the identification of a subgroup of patients at risk of restenosis in which long-term monitoring is recommended.
Source link: https://europepmc.org/article/MED/35847222
Purpose Carotid artery stenting is an alternative treatment option to carotid endarterectomy. Methods We retrospectively reviewed 308 patients with carotid stenosis who underwent CAS between April 2008 and April 2020. ISR patients with ISR were also investigated for contributing factors. Patients with a plaque/muscle ratio of u2264. 30 on T2-weighted magnetic resonance imaging on black-blood magnetic resonance imaging remained higher for patients with a plaque/muscle ratio of u2264 2. 30 on T2-weighted imaging on black-blood magnetic resonance imaging. On BB MRI T2WI, an independent risk factor for ISR was found as a positive risk factor for ISR in a plaque/muscle ratio of u2264 2. 30. On MRI T2WI, there was also a comparison of the occurrence of ISR and the plaque/muscle ratio value. The cutoff value for detecting ISR from BB MRI imaging was 1. 310 [area under the curve = 0. 9 percent, specificity = 85 percent]]. T2WI in pre-intervention MRI plaque imaging can be a useful predictor of post-intervention ISR.
Source link: https://europepmc.org/article/MED/35716405
After carotid artery stenting dramatically influence long-term CAS benefits and protection, In-stent restenosis has increased after carotid artery stenting positively influences long-term CAS benefits and protection. We retrospectively reviewed the clinical and imaging records of 221 patients who underwent pre-CAS carotid computed tomography angiography and whose digital subtraction angiography reports for determining ISR presence were also available. To produce a traditional model, Carotid plaque characteristics determined using CTA were used to determine CTA. ISR was detected in 30 patients by follow-up angiography. The combination of radiomics and plaque features provided the highest predictive results, with Plaque length and thickness able to independently predict post-CAS ISR.
Source link: https://europepmc.org/article/MED/35683623
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