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Carotid Restenosis - Crossref

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Last Updated: 09 August 2022

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Intraplaque high-intensity signal on time-of-flight magnetic resonance angiography and restenosis after carotid artery stenting

In the present observational study, we investigated the possibility that intraplaque hemorrhage is a predictor of restenosis after carotid artery stenting, and restnosis as a result of intraplaque hemorrhage is a predictor of restenosis. METHODS In the authors' U2019 department, consecutive patients who underwent initial CAS for atherosclerotic stenosis in the cervical internal carotid artery were accepted. Outcome initiatives were a result of a peak systolic velocity of > 1. 3 m/sec, or occlusion; and a 65% restenosis, which were described as a peak systolic velocity of > 2. 1 m/sec; or occlusion on carotid duplex ultrasound. The results of 230 consecutive patients who underwent initial CAS were rejected, and 22 without preprocedural cervical TOF-MRA were excluded. In four patients, there was no Ultrasound follow-up. 102 patients had u2265 percent restenosis during the follow-up period, while 36 had u2265 percent restenosis and 36 had u2265 70% restenosis.

Source link: https://doi.org/10.3171/2021.4.jns21546


Echolucent carotid plaque is associated with restenosis after carotid endarterectomy

Since CEA, our study sought to determine the correlation between the carotid plaque median value and restenosis. METHODS Between January 2010 and January 2018, 1280 consecutive patients underwent CEA at our hospital; 32 patients were diagnosed with restenosis by ultrasound at 1 year after CEA; 32 patients were diagnosed with restenosis by ultrasound at 1 year after CEA. CONCLUSIONS Predominantly echolucent carotid plaques, as determined by GSM, had a higher incidence of restenosis risk at 1 year than echogenic plaques.

Source link: https://doi.org/10.3171/2020.2.jns193397


Exosomes Derived from AT2R-Overexpressing BMSC Prevent Restenosis After Carotid Artery Injury by Attenuating the Injury-Induced Neointimal Hyperplasia

In this research, we investigated the effectiveness of exosomes derived from AT2R-overexpressing bone mesenchymal stem cells on the prevention of restenosis after carotid artery injury. AT2R-Exo were more absorbed in the injured carotid artery than EXO and Vehicle-EXO controls, according to a In vivo report. AT2R-EXO therapy may be able to restore blood flow to the injured carotid artery site more efficiently. AT2REXO prevents restenosis after the carotid artery injury, according to a new report, by attenuating the injury-induced neointimal hyperplasia.

Source link: https://doi.org/10.1007/s12265-022-10293-2


Impact of Diabetes Mellitus on Early Clinical Outcome and Stent Restenosis after Carotid Artery Stenting

Both the severity of carotid disease and its occurrence after revascularization are closely related to diabetes mellitus. After CAS, Carotid artery stenting has emerged as a viable alternative to surgical endarterectomy, but little is known about the effects of diabetes after CAS. At 30 days post-CAS and a year follow-up, a cumulative cohort of 1940 patients undergoing CAS in two hospitals was divided into two groups, diabetics and nondiabetics, and major cerebrovascular events were investigated, followed by a third cohort of 40 patients undergoing CAS in two institutions. Overall, the stroke/death rate in the asymptomatic patients was 2. 4%, but the restenosis rate was higher in the diabetes population.

Source link: https://doi.org/10.1155/2022/4196195


Prediction of Long-Term Restenosis After Carotid Endarterectomy Using Quantitative Magnetic Resonance Angiography

Aims After CEA using quantitative angiography techniques to detect patients at risk of long-term restnosis, it was determined that the use of immediate perioperative vessel flow measurements could be useful. Methods The study was conducted in a prospective cohort study with long-term sonographic follow-up after CEA for symptomatic internal carotid artery stenosis > 50%. Patients at risk of restenosis for up to ten years were identified as a result of QMRA's survey, which was used to determine patients at risk of restenosis for up to ten years. In patients without long-term restraint, both for the ipsilateral ICA and MCA, were substantial in contrast to those with restenosis. The ICA mean flow ratio tended to be more accurate than the MCA's in forecasting restenosis over the long run. Conclusion Our preliminary results show that after CEA, the increase in QMRA-based mean flow increases could be determinant of restnosis long term.

Source link: https://doi.org/10.3389/fneur.2022.862809


Relations between Plasma von Willebrand Factor or Endothelin-1 and Restenosis following Carotid Artery Stenting

Before and after CAS, plasma levels of VWF and ET-1 were measured in 61 patients. Mean VWF and ET-1 levels in the restenosis group were at 2 weeks, 1 and 6 months after CAS were higher than baseline averages. VWF and ET-1 in the restnosis group were higher than in the non-restenosis group just 6 months after CAS was announced. Conclusion: A persistent rise in plasma VWF and ET-1 within the first six months of CAS was discovered in patients with in-stent restenosis.

Source link: https://doi.org/10.1159/000337940


A Novel Rat Model of Carotid Artery Stenting for the Understanding of Restenosis in Metabolic Diseases

We established a carotid artery model of in-stent restenosis in the rat because there are many inbred strains of rats with these phenotypes. In male Wistar rats' common carotid artery, a detailed histomorphometric investigation was conducted on 2-cell Multi-Link TM stents deployed in the common carotid artery. By day 3, early focal thrombus formation around stent struts of adherent leukocytes was apparent. Neointimal cell proliferation peaked by day 7 and then decreased to 2% by day 60. The neointimal area had been significantly expanded by an increased number of u03b1-actin-positive smooth muscle cells surrounded by an extracellular matrix rich in versican and hyaluronan by day 14. This regression phase was followed by a dramatic rise in elastin fibrils and collagen type I. In summary, vascular recovery in the rat parallels that of larger mammals is accelerated relative to humans; however, it is quicker than humans.

Source link: https://doi.org/10.1159/000064518


Positive Effect of Treatment with Synthetic Steroid Hormone Tibolon on Intimal Hyperplasia and Restenosis after Experimental Endothelial Injury of Rabbit Carotid Artery

Methods: In vivo, the effects of Tibolon treatment on neointimal formation and arterial wall damage were investigated in vivo, using an animal model of balloon rupture of carotid artery. Tibolon's effect on eNOS and VEGF was determined by ELISA in human umbilical vein endothelial cells and human microvascular endothelial cells. Cell proliferation was induced by VEGF 165 and measured by BrdU incorporation assay, but cell apoptosis was discovered by colorimetrically measuring DNA fragmentation. Tibolon treatment did not influence the expression of eNOS protein in HUVEC nor cell proliferation rate, nor did cell proliferation rate, but it did reduce endothelial cell apoptosis by around 40%. Conclusions: Tibolon therapy suppressed neointimal formation and promoted improved repair of eroded vessel wall in carotid artery after balloon trauma.

Source link: https://doi.org/10.1159/000076646


The Probability of Restenosis, Contralateral Disease Progression, and Late Neurologic Events following Carotid Endarterectomy: A Long-Term Follow-Up Study

Methods: We looked at all patients with CEA for symptomatic high-grade ICA stenosis between 1970 and 2002, based on a single-center carotid endarterectomy registry. After 5 years, the likelihood of progressive ICA disease was 5. 2% for the ipsilateral versus 15. 8% for the contralateral ICA. In the absence of progressive restanosis of the ipsilateral ICA, the 20-year risk of more ischemic cerebrovascular disease was 55% compared to 18% in patients without ICA disease progression. For the contralateral ICA, the chance of further ischemic events was 24. 5% in patients with ICA disease progression compared to 9. 6% without ICA disease progression. Although ICA disease progression seems to be more prominent on the contralateral ICA in the first years, this difference fades out after 15 years. One of two patients with ipsilateral ICA disease progression can be expected to have a recurrent cerebral ischemic event within 15 years, according to one of two patients with ipsilateral ICA disease progression.

Source link: https://doi.org/10.1159/000166843


Significance of Carotid Restenosis following Endarterectomy

Background and Purpose: Renosis after carotid endarterectomy as revealed by duplex ultrasound has not been established, and its clinical significance has not well established. All charts of patients with carotid endarterectomies between June 1987 and 1995 were reviewed. Patients with ipsilateral high- and low-grade restenosis had similar event rates. On serial ultrasound, there was no such difference in event rates shown for patients with ipsilateral progression of carotid disease. However, patients treated for acute carotid disease had a markedly elevated risk of neurological events. During the follow-up, logistic regression failed to identify any other risk factors that were independently predictive of either restenosis or vascular events. Conclusion: After carotid endarterectomy, this report does not show any difference in vascular event rates for higher grades of carotid restenosis. Routine catheterization with carotid ultrasound does not appear to identify patients at a higher risk of postoperative cerebrovascular events.

Source link: https://doi.org/10.1159/000015877

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions