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Objectives of this research This study was designed to compare the characteristics of carotid plaques between patients with transient ischemic attack and ischemic stroke using magnetic resonance imaging. Patients with a recent ischemic stroke or TIA who had atherosclerotic plaques of carotid arteries in the symptomatic directions determined by MR vessel wall imaging were recruited by patients with a recent ischemic stroke or TIA. Resultes A total of 270 patients with TIA or ischemic stroke were recruited. Compared to those with TIA, Stroke patients had a significantly elevated risk of diabetes, greater mean wall thickness, maximum normalized wall thickness, and %volume of LRNC in the carotid arteries. Conclusions In comparison to those with TIA, Ischemic stroke patients had a higher plaque burden and a higher risk of LRNC in carotid plaques than those with TIA. According to this report, ischemic stroke patients had more fragile plaques than those with TIA.
Source link: https://europepmc.org/article/MED/35448952
Scable score includes stenosis severity and inflammation determined by Positron-Emission Tomography, which also increases the detection of patients with recurrent strokes compared to lumen-stenosis alone. We investigated whether the SCAIL score increases the detection of recurrent stroke in subgroups of uncertain benefit from endarterectomy trials with uncertain results. Patients with a recent non-severe anterior circulation disease/TIA are eligible patients; ipsilateral mild carotid stenosis; carotid stenosis plus at least one of female sex, diabetes mellitus, TIA, or postponement of > 14 days from revascularization; or monocular loss of vision. The SCAIL score aided in the discovery of early recurrent stroke in subgroups that did not participate in endarterectomy trials. The SCAIL score correctly distinguishes those at risk for recurrent ipsilateral ischemic stroke in patients with recent anterior circulation ischemic stroke who do not benefit from carotid revascularization.
Source link: https://europepmc.org/article/MED/35418461
We wanted to investigate the links between carotid vulnerable plaque diseases coexisting with cerebral small vessel disease and acute ischemic stroke, and, in addition, we wanted to determine if coexisting conditions were more prevalent with AIS than a single disease. Patients with cerebrovascular disease and carotid plaque were recruited from the cross-sectional, multicenter CARE-III study. Compared to carotid lesions alone, multivariate analysis revealed that carotid plaque features coexisting with lacunes or moderate-to-severe WMHs had a higher correlation with AIS than carotid lesions alone. In a large, symptomatic cohort, a largely unhealthy carotid plaque features coexisting with CSVDs, particularly lacunes, had a higher association with AIS than carotid lesions alone. Compare to single disease in symptomatic patients, the Carotid vulnerable plaque has a higher correlation with acute ischemic stroke in coexisting with cerebral small vessel diseases, such as lacunes, among other things.
Source link: https://europepmc.org/article/MED/35364716
paraphrased plaque in an ESUS population investigated the relationship between left atrial enlargement and nonstenotic carotid plaque in a young population. Methods ESUS's prospective multicenter cohort of consecutive patients with unilateral, anterior circulation ESUS was searched. Descriptive studies were used to compare plaque features in relation to age and left atrial dimensions. The ipsilateral versus contralateral plaque thickness in the total cohort was more compared to the stroke hemisphere in the stroke hemisphere; however, the subgroup of patients with no LAE accounted for the majority of this. The younger patients had more carotid plaque ipsilateral versus contralateral, and less severe-to-severe LAE than those who were younger than 70 years old. Conclusions : Younger patients with ESUS had a higher risk of ipsilateral nonstenotic plaque, whereas the elderly had more LAE. In future studies, the effect of age on the likelihood of specific mechanisms underlying ESUS should be considered.
Source link: https://europepmc.org/article/MED/35354301
Using plaque 3-D modeling and image analysis, we hope to enhance stroke risk stratification of patients with carotid artery stenosis. Patients with CTAs appropriate for 3-D reconstruction were found from an NIH designated stroke center website, and carotid arteries were segmented and analyzed using software tools to determine contact surface area between the plaque and blood flow, as well as the number of the flow lumen within the region of the plaque. Both CSA and LV displayed more dependable results in predicting stroke risk in patients with carotid stenosis, despite being located within the receiver operating characteristics curve between NASCET percent stenosis, CSA, and LV. The results presented here show morphological characteristics of carotid plaques that are independent of NASCET criteria stratification and classification, and may indicate an improved method to determining stroke risk in patients with carotid artery stenosis.
Source link: https://europepmc.org/article/MED/35351605
Carotid plaque inflammation has been identified by fluorodeoxyglucose positron emission tomography, which predicts stroke recurrence in patients with atherothrombotic stroke. According to 18F-FDG uptake, the study was designed to identify plasma inflammatory biomarkers associated with plaque inflammation. We carried out a prospective analysis of consecutive adult patients with a recent anterior circulation ischemic stroke and at least one atherosclerotic plaque in the ipsilateral internal carotid artery. To determine the correlation between plasma biomarkers and the 18F-FDG uptake rate, a multivariable linear regression was used. plaque inflammation was not directly related to plaque inflammation, according to Soluble's intercellular adhesion molecule-1, a soluble vascular adhesion molecule-1, and fractalkine. To determine the relationship between biomarkers and stroke recurrence, a multivariable Cox regression was used. In patients with new ischemic stroke and carotid atherosclerosis, elevated levels of sICAM-1 were attributed to carotid plaque inflammation and an elevated risk of stroke recurrence.
Source link: https://europepmc.org/article/MED/35237947
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