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The appearance of noncalcified portions of the carotid atherosclerotic plaque is a key indicator of plaque vulnerability and ischemia risk. With histologic findings from carotid endarterectomy as the reference, the aim of this study was to determine the performance of dual-layer spectral detector CTA parameters for the characterization of carotid plaque components. Seven patients with carotid plaque awaiting carotid endarterectomy were prospectively registered and underwent preoperative supraaortic DLCTA. The AUC for CT 40kev was the highest for CT 40kev and decreased with greater power, but it was not 0. 908. CT 40kev had the highest sensitivity and 91. 0% specificity, at a cutoff of 55. 7 HU, with 88. 5% sensitivity and 91. 0% specificity. AUC was the highest at 0. 652 for CT PI and 0. 645 for CT 40kev, with distinguishing IPH from fibrous tissue and loose matrix. DLCTA measurements may help distinguish carotid plaque composition as a marker of vulnerable plaque and ischemia risk.
Source link: https://europepmc.org/article/MED/34549604
Aims, Calif. The aim of this research was to compare the periprocedural asymptomatic cerebral embolism rates of CAS procedures performed for noncalcified and calcified carotid artery plaque plaques using diffusion-weighted magnetic resonance imaging. Methods 570 retrospectively reviewed patients who underwent CAS at our center from December 2010 to June 2020. As noncalcified and calcified plague groups were divided into two groups, the patients were divided into 2 groups. The non-calcified and calcified plaque groups found on cerebral DW-MRI were compared, and the non-calcified and calcified plaque groups' diffusion limits were not measurable. P = 0. 02. Results The presence of periprocedural asymptomatic ipsilateral DW-MRI lesions in the noncalcified plaque group was greater in patients in the noncalcified plaque group than in and patients in the calcified plaque group, with a determinant plaque group, P = 0. 02. Result This research found that the rate of ipsilateral asymptomatic cerebral embolism detected on cerebral DW-MRI was higher in the CAS procedures for noncalcified artery plaques than those used for calcified plaques.
Source link: https://europepmc.org/article/MED/35040483
Background: Using magnetic resonance imaging, this research was designed to compare the characteristics of carotid plaques between patients with transient ischemic attack and ischemic stroke. Patients with a recent ischemic stroke or TIA who had atherosclerotic plaques of carotid arteries in the symptomatic areas established by MR vessel wall imaging were recruited. 270 patients with TIA or ischemic stroke were recruited, with a total of 270 patients. Compared to those with TIA, Stroke patients had remarkably high incidence of diabetes, increased mean wall thickness, mean wall thickness, maximum normalized wall thickness, and % of LRNC in carotid arteries. Conclusions: : In contrast to those with TIA, Ischemic stroke patients had higher plaque burden and a greater percentage of LRNC in carotid plaques. According to this report, ischemic stroke patients had more fragile plaques than those with TIA.
Source link: https://europepmc.org/article/PPR/PPR432738
paraphrased plaque plaques and examine the effects of SPION ultrasound imaging in inflammatory plaque visualization effects. Our research sought to investigate the use of superparamagnetic iron oxide nanoparticle ultrasound imaging to detect the presence of vascular cell adhesion molecule-1 in patients with carotid plaques and analyze the effects of SPION ultrasound imaging in inflammation plaque visualization. Both in vivo and in vitro, SPION microbubble contrast agents exhibit good imaging results. The results revealed that the SPION contrast agent carrying VCAM-1 antibody had higher peak gray-scale video intensity than the other two groups of contrast agents not carrying VCAM-1 antibody.
Source link: https://europepmc.org/article/MED/34899973
This study sought to produce an anti-Vascular cell adhesion protein 1 nanoscale ultrasound microbubble contrast agent for the molecular analysis of rabbits with atherosclerotic vulnerable plaques. As follows: Groups A and B: twenty-five rabbits with carotid atherosclerosis were randomly divided into 5 groups; Groups C and D: SonoVue ultrasonic microbubble contrast agent with and without anti-VCAM-1 agent; Control group: saline; Groups A and B: carotid atherosclerosis; Groups A and B: ultrasonic microbubble contrast agent with and without anti-VCAM-1 agent; Groups The introduction and peaking time of the anti-VCAM-1 nanoscale ultrasound microbubble contrast agent for plaque was earlier than that of the other groups, and with it, the plaque achieved the most significant improvement, followed by the SonoVue ultrasound microbubble contrast agent and the self-made nanoscale ultrasound microbubble contrast agent group.
Source link: https://europepmc.org/article/MED/34957808
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