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Carotid Plaque - Europe PMC

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Last Updated: 02 January 2023

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Evaluation of carotid plaque vulnerability with different echoes by shear wave elastography and CEUS.

Investigate carotid plaques with different echoes with shear wave elastography and contrast enhanced ultrasound to examine carotid plaques with different echoes, as well as a simple way to characterize carotid plaques with fragile carotid plaques. The connection between GSM and YM and CEUS values was investigated. The differences between GSM values in the vulnerable and stable plaque groups were shown by statistically significant differences between the above indicators — with the highest, mean, and minimum YM values of ultrasound elastography, as well as the lower the echogenicity of the plaque; and the lower the YM values — the lower the YM values ; and the higher the neovascularization number and density; and minimum YM values were also statistically significant differences between the above measurements —both :.

Source link: https://europepmc.org/article/MED/36586243


Tryptophan metabolism, gut microbiota, and carotid artery plaque in women with and without HIV infection

Methods We included 361 women with carotid artery plaque measurements from the Women's Interagency HIV Study, which measured ten plasma TRP metabolites, as well as profiled fecal gut microbiome. Through the Study of Compositions of Microbiomes with Bias Correction method, TRP metabolites related to gut microbial species were selected. Using multivariable logistic regression, TRP metabolites and related microbial characteristics with plaque were investigated. Plaque, indole-3-propionate, and IPA/KYNA were both positively associated with plaque, whereas plaque, kynurenic acid and KYNA/TRP were positively associated with plaque, indole-3-propionate, and IPA/KYNA were inversely related to plaque. Conclusions: In a cohort of women living with and without HIV, plasma IPA levels, and related gut bacteria were closely associated with carotid artery plaque, indicating a potential role for IPA and its gut bacterial producers in atherosclerosis and CVD.

Source link: https://europepmc.org/article/PPR/PPR589390


Quantification of Local Vessel Wall and Plaque Volume Change for Assessment of Effects of Therapies on Carotid Atherosclerosis Based on 3-D Ultrasound Imaging.

With the voxel-based VWV conversion factor that was determined in the baseline and follow-up photos, the vessel wall area was divided into small voxels. Computing the mean u0394VVol% over the entire 3-D chart for each patient was calculated by a new patient-based biomarker. Patients randomized to pomegranate juice/extract/ placebo groups demonstrated a significant difference between patients randomized to placebo and placebo groups, according to u0394VVol%u00af. About a third of that required by the local VWT biomarker was approximately a third of that needed by the local VWT biomarker.

Source link: https://europepmc.org/article/MED/36566092


Feasibility and accuracy of measuring carotid plaque volume (burden) with contrast-enhanced tomographic 3D ultrasound and ultrasound image fusion.

Objectives: Stenosis severity has been the cause of carotid endartarterectomy for four decades, but the annual stroke risk in asymptomatic carotid stenosis > 70% is less than 2%. Tomographic ultrasound is a new process that creates 3D images in seconds. In patients undergoing CEA, we verified the reliability of measuring Carotid Plaque Volume with tUS. Meansd CPV measured by tUS was 0. 87 cm3 at 3 u00b10. 51 cm 3; for fusion, averaged 1. 83u00b10. 49cm 3, a 1 % 0. 83 u00b10. 49cm 3. If precise CPV measurements are required for analysis, CEtUS improves accuracy, but population screening by tUS alone would be sufficient.

Source link: https://europepmc.org/article/MED/36563846


A Single-Cell Atlas of the Atherosclerotic Plaque in the Femoral Artery and the Heterogeneity in Macrophage Subtypes between Carotid and Femoral Atherosclerosis.

For example, it is important to determine the cellular composition of the femoral atherosclerotic plaque and detect plaque heterogeneity in other arteries. We found 14 cell types, including endothelial cells, smooth muscle cells, monocytes, three macrophages, three macrophages with four distinct subtypes of foam cells, three T cells, natural killer cells, and B cells. We found similar cell types in the femoral artery, but the carotid artery had significantly more nonspecific immune cells and fewer specific immune cells than the carotid artery. The proportion of inflammatory macrophages, resident macrophages, and inflammatory macrophages was higher within the carotid artery, according to a study published in this journal. Our research shows the single-cell map of the femoral artery and the heterogeneity of carotid and femoral arteries at the cellular level, laying the foundation for mechanistic and pharmacological studies of the femoral artery.

Source link: https://europepmc.org/article/MED/36547462


Elevated EMMPRIN serum levels indicate plaque vulnerability in patients with asymptomatic high grade carotid stenosis.

Because of its role in plaque formation/destabilization as a possible marker of high-risk vulnerable plaques, the purpose of our research was to determine extracellular matrix metalloproteinase inducer as a potential predictor of high-risk vulnerable plaques. paraphrased artery stenosis in preoperative blood serum samples from patients with symptomatic and asymptomatic carotid artery stenosis were tested by a specific ELISA. Patients with echolucent plaques had significantly higher incidences in patients with echolucent plaques than to echogenic plaques, according to a circulating EMMPRIN study. Compared to non-vulnerable plaques, Asymptomatic patients with vulnerable plaques had significantly elevated EMMPRIN levels. With an AUC of 0. 71 percent, asymptomatic patients with a hazy plaques discovered in logistic regression studies, duplex sonography, age, sex, and medical risk factors predicted vulnerable plaques in asymptomatic patients with a risk factor. EMMPRIN may be used for preoperative risk stratification in asymptomatic patients, as well as duplex sonography.

Source link: https://europepmc.org/article/MED/36529365


Deep learning based on carotid transverse B-mode scan videos for the diagnosis of carotid plaque: a prospective multicenter study.

Objectives To prevent strokes, accurate detection of carotid plaque using ultrasound is essential for preventing strokes. To enhance junior radiologists' accuracy in plaque detection, we therefore intend to create a deep learning system based on U. S. videos. From carotid transverse U. S. videos allowing clinical identification, CaroNet-Dynamic automatically identified carotid plaque from carotid transverse U. S. videos allowing clinical identification. Model robustness was tested on various plaque types and U. S. scanning techniques. According to the internal and multicenter external test sets, respectively, the DL model demonstrated high results with sensitivities of 87. 3 percent and 94. 1 percent, specificities of 82. 07% and 74. 04%, and regions under the receiver operating characteristic curve, which curves of 0. 845 and 0. 841 were characterized by 87. 03% and 86 percent. Conclusions The DL model based on U. S. videos corresponding to real examinations demonstrated strong results for plaque detection and significantly enhanced junior radiologists' diagnostic results. The deep learning scheme, which is based on U. S. videos conforming to real examinations, showed good results for plaque detection.

Source link: https://europepmc.org/article/MED/36512047


Heterogeneous Carotid Plaque Predicts Cardiovascular Events after Percutaneous Coronary Intervention.

Aim The relationship between carotid artery ultrasound findings and clinical outcomes in patients undergoing percutaneous coronary intervention has not been clear. Methods This single-center retrospective review of 691 patients who underwent PCI and carotid ultrasound examination found 691 patients. The maximum CIMT thickness was measured at the maximum thickness among the common carotid artery, carotid bulb, and internal carotid artery. With a CIMT u2265 1. 5 mm, a carotid plaque was defined as vessel wall thickening. The physical features of a carotid plaque were examined scientifically. Patients were divided into those with and without heterogeneous carotid plaques. Patients with heterogeneous plaques were at a higher risk of MACE than those without. Conclusions The presence of a heterogeneous carotid plaque in patients who underwent PCI predicted future CV events.

Source link: https://europepmc.org/article/MED/36503894


microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician's Perspective.

One of the leading causes of mortality and disability in industrial countries is an Ischemic stroke related to atherosclerosis of large arteries. In 20% of all cerebral ischemia patients, Atherosclerotic internal carotid artery stenosis accounts for 20 percent. There are some research studies into the relationship between small non-coding microRNA expression and risk of carotid plaque formation and vulnerability. All major studies on carotid atherosclerotic plaque were carried out on cell culture or animal models; few were done on humans, in comparison; increasing results show that it cannot be automatically transferred to human processes. This paper seeks to review the most current research on how miRNA plays a role in carotid plaque formation and rupture, as well as stroke incidences. We discuss the possibility of a target miRNA that could be used as a prognostic or therapeutic device.

Source link: https://europepmc.org/article/MED/36555285


Translational Molecular Imaging Tool of Vulnerable Carotid Plaque: Evaluate Effects of Statin Therapy on Plaque Inflammation and American Heart Association-Defined Risk Levels in Cuff-Implanted Apolipoprotein E-Deficient Mice.

Asymptomatic patients' detection of high-risk carotid plaques is a difficult but critical step in stroke prevention. The challenge is to precisely monitor the growth of high-risk carotid plaques and quickly identify patients, who are unresponsive to best medical care and therefore primed for carotid surgical interventions to avoid strokes. Exploiting this platform, we have developed smart molecular magnetic resonance imaging probes made up of dual-targeted microparticles of iron oxide against VCAM-1 and P-selectin to determine the anti-inflammatory effects of statin therapy on progressive carotid atherosclerosis. In vivo DT-MPIO-enhanced MRI can quantitatively track plaque inflammation from the start to advanced stage; identify and characterize high-risk inflamed, fragile plaques; and track statin therapy's response longitudinally.

Source link: https://europepmc.org/article/MED/36481841

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions