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Background and goals It is unclear if there is a correlation between carotid plaques and flow velocities with peak-width mean diffusivity and white matter hyperintensities independent of shared risk factors. The difference between the 95th and 5th percentiles of MD values on the white skeleton's standard space Volumes of WMH was determined by a manually trained k-nearest neighbor segmentation algorithm. Low PSV was associated with pWMH and the presence of CP with pWMH and dWMH. Low PSV and CP are both related to WMH and PSMD, independent of cardiovascular risk factors and biomarkers of inflammation and cardiac dysfunction. This leads to pathophysiological pathways underlying both large and small vessel disease with conditions that are not typical cardiovascular risk profiles.
Source link: https://europepmc.org/article/MED/36123124
Objective In comparison with Computed Tomography angiography and histology, our aim is to determine Multiparametric Ultrasound's effectiveness for determining carotid plaque risk and carotid stenosis degree in comparison to Computed Tomography and histology. 3D-Arterial Analysis is a 3D ultrasound system that automatically provides the degree of carotid stenosis and a colorimetric map of carotid plaque vulnerability. All carotid artery plaque plaques were evaluated with Color-Doppler-US, Contrast-Enhanced Ultrasound, and 3D Arterial analysis in the United States before being hospitalized to determine the carotid artery stenosis degree prior to surgical intervention, according to Computerized Tomographic Angiography. Results of the CTA investigations revealed 91 patients with severe carotid stenoses with a resultant diagnostic accuracy of 82. 3% for CDUS, 94. 5% for 3DAA, respectively, 94% for 3DAA. Conclusions: CEUS and 3D Arterial Analysis together could be a useful new clinical tool to identify and stratify patients with atherosclerotic carotid artery disease, as well as identifying vulnerable plaques.
Source link: https://europepmc.org/article/MED/36114929
Both carotid and coronary atherosclerotic plaques are designed to highlight sex-related features, which could be used to analyze CV risk of male and female populations. This paper is intended to review existing research on sex-specific qualitative and quantitative plaque features of coronary and carotid atherosclerosis.
Source link: https://europepmc.org/article/MED/36176995
Various sizes of INVs coexist in carotid plaques pathologically, and we hypothesized that the number of INVs would be associated with carotid plaque histology, particularly in terms of intraplaque hemorrhage. The aim of this research was to investigate the relationship between findings from CEUS and vascular pathology obtained by carotid endarterectomy. Results Multivariable tests indicated that CEUS Vas-G0 was associated with the 4th quartile of small INVs relative to other quartiles, and that Vas-G10 was associated with the 4th quartile of large INVs in comparison to other quartiles. The number of small INVs increased was related to infrequent plaque disruption and thicker fibrous cap, according to histologically. Conclusions According to the authors' report, early phase in the CEUS can help identify plaque risk by predicting a greater number of small INVs.
Source link: https://europepmc.org/article/MED/36099902
Background The present research was designed to look at the possibility that the outer wall of the carotid bifurcation is the most common area of atherosclerotic plaque deposition due to low shear stress. Hypothesis We hypothesized that in both the early and late stages, the most common site of arteriosclerosis in carotid arteries is different. paraphrased arteries identified by Duplex ultrasound in our health promotion center, which is a non-stenosis of the common and internal carotid arteries. Methods This is an observational study of patients with 50 percent stenosis of the common and internal carotid arteries. The Plaque location was classified as a quarter of the cross-section in the distal common carotid artery and proximal ICA. The Carotid plaque score was calculated by the addition of a point for each identified segment. Among the 569 patients between June 2020 and October 2020, a total of 569 patients was included in the 3996 Duplex scans of carotid arteries in 999 patients between June 2020 and October 2020.
Source link: https://europepmc.org/article/MED/36086944
Background D-Dimer and fibrinogen were both commonly used to determine coagulation and fibrinolytic function in young patients aged 18-45 with acute cerebral infarction, but the D-dimer to ufb01brinogen ratio in carotid plaque in young patients aged 18-45 with acute cerebral infarction has not been used clinically. After their first admission, a total of 164 patients with ACI patients aged 18-45 were chosen as research subjects. They had undergone carotid plaque contrast-enhanced ultrasound and were divided into two groups with carotid plaque and no carotid plaque. To determine the risk factors of carotid plaque in ACI patients, two univariate and multivariate studies were conducted. Patients in the carotid plaque group had a higher DFR value than those in the no carotid plaque control group, which was much higher than that of the no carotid plaque control group. Conclusion The value of the DFR is positively correlated with CEUS carotid plaque grading and NIHSS scores, which can indicate the presence of carotid plaque in ACI patients aged 18 to 45.
Source link: https://europepmc.org/article/MED/36108464
We developed expression profiles of lncRNAs, microRNAs, and mRNA in the carotid plaque of atherosclerosis patients in the carotid plaque of atherosclerosis patients and analyzed differentially expressed genes based on RNA sequencing results. MiRNA target miRNAs were determined by LNCipedia, TargetScan, and miRDB databases in order to identify target miRNAs of lncRNAs and miRNA target genes of miRNAs. According to the "MCC" method used by the plug-in cytoHubba in Cytoscape, ERCC4 was the top hub gene of the PPI network. We developed a lncRNA_FGF7-5/lncRNA_GLRX3-miR-2681-5p-ERCC4 regulatory network for a carotid plaque using lncRNA-mRNA and miRNA-mRNA pairs, which was developed by We built a lncRNA-mRNA network. Next, lncRNA_FGF7-5 and lncRNA_GLRX3 targeted miR-2681-5p specifically to upregulate ERCC4 expression, triggering erCC4 expression. Silencing of lncRNA-FGF7-5 and lncRNA_GLRX3 in HUVECs treated with ox-LDL has promoted apoptosis and TP53 expression in ox-LDL-treated HUVECs, but these effects were reversed by ERCC4-overexpression. These results combined showed that lncRNA-FGF7-5 and lncRNA_GLRX3 together reduced atherosclerosis-induced apoptosis of HUVECs by targeting miR-2681-5p to increase ERCC4 expression, thus preventing the formation of carotid plaque and ultimately inhibiting atherosclerosis progression.
Source link: https://europepmc.org/article/MED/36071684
Background Carotid plaque vulnerability is one of the key attributes for determining the risk of subsequent ischemic strokes. Although magnetic resonance imaging is the gold standard for determining plaque risk, some patients are unable to perform MRI due to physical or financial reasons. Before carotid revascularization at our hospital, we retrospectively reviewed consecutive patients who underwent plaque imaging using CT and MRI. On MRI for determining plaque risk and comparing between types of calcification and SIR, a measurable ratio of carotid plaque was determined. Resultation Among the 132 patients tested, 50 patients in the DLS positive group, and 16 patients in the DLS negative group all had calcification with vulnerable plaque calcification. DLS and male sex, according to a multivariate study, were independent predictors of fragile plaque. Conclusions DLS in our latest classification of calcification on CT reliably detects vulnerable plaque and can therefore be used in patients who are unable to undergo MRI.
Source link: https://europepmc.org/article/MED/36058484
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