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People with atherosclerosis, plaque buildup in the arteries that supply blood to the heart, and carotid artery disease, which causes plaque buildup in the arteries that lead to blood flow to the brain, are at risk of coronary artery disease. People with more fat in atherosclerotic plaque may be at a higher risk of experiencing a heart attack or stroke, according to studies. This research will determine whether these drugs alone or in combination can reduce the fat content of atherosclerotic plaques within the carotid arteries of people with coronary artery disease and carotid artery disease. This research will include people with coronary artery disease or carotid artery disease. Participants will be randomly assigned to one of the following 40-month treatment groups: Each day, participants in Group 1 will be given atorvastatin, placebo niacin, and placebo colesevelam. Each day, participants in Group 2 will be given atorvastatin, niacin, and placebo colesevelam. Participants will be given a blood sample and nutritional advice focusing on cholesterol lowering at a baseline study visit to a baseline study visit. Participants will attend monthly study visits for repeat blood analysis and dietary advice for the next four months, and for the next 36 months, participants will attend study visits every other month. Repeat carotid artery MRI scans will be available at months 12, 24, and 36. Participants will be asked to track their food intake for three days in a row at three different times during the study.
Source link: https://clinicaltrials.gov/ct2/show/NCT00715273
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