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Abstract Mycotic cerebral aneurysms can pose specific neurosurgical difficulties. We describe a patient with left carotid occlusions, a ruptured left middle cerebral artery mycotic aneurysm, and a rapidly developing left anterior cerebral artery mycotic aneurysm in the event of mitral valve endocarditis with a perivalvular leak and growing concomitable heart failure.
Source link: https://doi.org/10.1055/s-0035-1555748
Methods: A methanolic extract of P. dactylifera fruits in doses of 30, 100, 300 mg/kg was tested in rats with permanent BCCAO in rats. MEPD occlusion therapy for 15 d. with 100 and 300 mg/kg doses significantly reduced the elevated malondialdehyde levels and reversed the aging of antioxidant enzymes in hypoperfused rats' brain homogenates. Conclusions: These findings demonstrated the protective role of P. dactylifera in ischemia hypoperfusion and, in turn, its beneficial role in cerebrovascular insufficiency states and related disorders.
Source link: https://doi.org/10.1016/S2221-6189(14)60026-3
In a mouse model of Vain induced by repeated ischemia-reperfusion of the total bilateral artery, the aim of this research was to determine the molecular mechanisms underlying the protective effects of fisetin, a flavonoid present in many fruits and vegetables. The protective effects of fisetin could be due to the inhibition of ROS-induced inflammation of NF-/NLRP3 inflammasome and the activation of antioxidant Nrf2/HO-1, suggesting a potential crosstalk between these molecular pathways.
Source link: https://doi.org/10.3390/biomedicines10061448
PURPOSE: To investigate morbidity, mortality, and microbiological reactions to fecal peritonitis-induced in Wistar rats with permanent bilateral carotid ligation. After a four-month postoperative follow-up, Fecal peritonitis was found in 30 rats, with 10 rats in each group; Group1 - normal young animals; and Group3 - rats with PBCL. RESULTS: The morbidity and mortality of young animals were markedly lower than those of mature animals with and without PBCL. The septicemia bacteria microbiota of the large bowel was similar to native microbiota of the large bowel.
Source link: https://doi.org/10.1590/S0102-86502013000400010
The prevalence of intracranial aneurysms in patients with internal carotid artery stenosis is also higher among intracranial aneurysms, likely due to intracranial hemodynamics changes. One ICA's stenosis or occlusion of one ICA can result in increased demand and altered hemodynamics in the contralateral ICA, raising the possibility of contralateral IA formation. Emergent angiography found a left-sided A1-A2 junction, paraphrased's left middle cerebral artery bifurcation, and left the anterior temporal artery aneurysms. The right anterior circulation artery through the anterior communicating artery was also identified, indicating increased demand on the left ICA circulation. We searched PubMed and EMBASE databases for case studies and case series, as well as references in earlier published review papers that described patients with concurrent aneurysms and ICA stenosis. The ICA stenosis showed that a greater number of patients with multiple aneurysms contralateral to rather than ipsilateral to, as shown by our analysis.
Source link: https://doi.org/10.4103/bc.bc_1_20
paraphrasedoutput:Methods: Sixty-five consecutive patients with unilateral carotid artery stenosis and contralateral carotid occlusion in hours after carotid artery stenting by transcranial Doppler or transcranial color code Doppler were enrolled. 14 patients had ipsilateral stenosis and CCO, while the other 51 patients had only unilateral acute carotid stenosis without CCO. Following CAS, the magnitude of ipsilateral MCA PSV increase was much higher in the CCO group than the UCS group at 1 h and 3 h, although BP decreased between the two groups. Conclusion: In patients with a stenosis degree of 70 percent or less in the CCO group, ipsilateral MCA PSV increases were marginally higher in the first hours after unilateral CAS in patients without CCO.
Source link: https://doi.org/10.3389/fneur.2019.00958
After carotid endarterectomy, a new investigation into cerebral and ocular blood flow velocity in patients of carotid stenosis with or without contralateral carotid occlusion began early. On the ipsilateral side of CEA, significant reductions in BFV were seen in patients with unilateral CS in anterior cerebral artery and middle cerebral artery. In patients of ipsilateral CS and contralateral CO, significant rises in BFV were found in the ACA and MCA not only on the ipsilateral but also on the contralateral side postoperatively.
Source link: https://doi.org/10.1155/2016/2901028
Acute carotid occlusion is a rare but critical complication that can result following a carotid endoacrterectomy procedure. Endovascular therapy was used to restore the proper ICA vessel caliber and cerebral blood flow by a thromboaspiration catheter. Endovascular therapy could be a post-CEA acute occlusions, particularly in patients with an intracranial perfusion deficit, allowing the operator to address both problems and minimize the overall ischemic time.
Source link: https://doi.org/10.1016/j.inat.2021.101152
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