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Carotid Intima-Media Thickness - DOAJ

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Last Updated: 03 September 2022

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Carotid intima-media thickness and oxidative stress markers for assessment of atherosclerosis in children with β thalassemia major

" The present research study examines carotid intimamedia thickness in children with \ u03b2 thalassemia major to assess atherosclerosis and its connection to the underlying proposed causative mechanisms via lipid peroxidation item malondialdehyde, oxidized lowdensity lipoproteins, complete antioxidant degree, and lipid profile. In our research study, CIMT was considerably increased in \ u03b2 thalassemia major patients \ u2019 as compared to healthy controls. In our study we found MDA degrees to be increased in \ u03b2 thalassemia patients as contrasted to controls. Our study results show CIMT as a very early marker of atherogenesis in \ u03b2 thalassemia significant. Oxidative stress pens are increased in \ u03b2 thalassemia significant patients and lipoprotein shows a positive connection with CIMT. Today study points in the direction of different atherogenetic mechanisms in \ u03b2 thalassemia major. \ u672c \ u7814 \ u7a76 \ u8bc4 \ u4ef7 \ u03b2 \ u91cd \ u578b \ u5730 \ u4e2d \ u6d77 \ u8d2b \ u8840 \ u60a3 \ u513f \ u9888 \ u52a8 \ u8109 \ u5185 \ u819c \ u4e2d \ u5c42 \ u539a \ u5ea6 \ uff08CIMT \ uff09 \ uff0c \ u4ee5 \ u8bc4 \ u4f30 \ u52a8 \ u8109 \ u7ca5 \ u6837 \ u786c \ u5316 \ uff0c \ u4ee5 \ u53ca \ u4e0e \ u6f5c \ u5728 \ u901a \ u8fc7 \ u8840 \ u8102 \ u8fc7 \ u6c27 \ u5316 \ u53cd \ u5e94 \ u4ea7 \ u7269 \ u4e19 \ u4e8c \ u919b \ uff08MDA \ uff09 \ u3001 \ u6c27 \ u5316 \ u4f4e \ u5bc6 \ u5ea6 \ u8102 \ u86cb \ u767d \ uff08LDL \ uff09 \ u3001 \ u603b \ u6297 \ u6c27 \ u5316 \ u6c34 \ u5e73 \ u548c \ u8840 \ u8102 \ u8c31 \ u6240 \ u63d0 \ u51fa \ u81f4 \ u75c5 \ u673a \ u5236 \ u4e4b \ u95f4 \ u7684 \ u5173 \ u7cfb \ u3002 \ u572862 \ u540d \ u513f \ u7ae5 \ uff0831 \ u4f8b \ u75c5 \ u4f8b \ u548c31 \ u4f8b \ u5bf9 \ u7167 \ uff09 \ u4e2d \ u8fdb \ u884c \ u4e86 \ u4e00 \ u9879 \ u6a2a \ u65ad \ u9762 \ u7814 \ u7a76 \ u3002 \ u5728 \ u5165 \ u7ec4 \ u53d7 \ u8bd5 \ u8005 \ u4e2d \ u901a \ u8fc7 \ u9ad8 \ u5206 \ u8fa8 \ u7387 \ u8d85 \ u58f0 \ u548c \ u751f \ u5316 \ u6307 \ u6807 \ uff08 \ u5373 \ u603b \ u80c6 \ u56fa \ u9187 \ u3001 \ u7518 \ u6cb9 \ u4e09 \ u916f \ u3001 \ u9ad8 \ u5bc6 \ u5ea6 \ u8102 \ u86cb \ u767d \ u3001LDL \ u3001 \ u6c27 \ u5316LDL \ uff0c \ u8102 \ u86cb \ u767d \ uff08a \ uff09 \ u3001 \ u8840 \ u8102 \ u8fc7 \ u6c27 \ u5316 \ u4ea7 \ u7269MDA \ u548c \ u603b \ u6297 \ u6c27 \ u5316 \ u5242 \ uff09 \ u6d4b \ u91cfCIMT \ u5e76 \ u8fdb \ u884c \ u6bd4 \ u8f83 \ u3002 \ u5728 \ u6211 \ u4eec \ u7684 \ u7814 \ u7a76 \ u4e2d \ uff0cCIMT \ u5728 \ u03b2 \ u91cd \ u578b \ u5730 \ u4e2d \ u6d77 \ u8d2b \ u8840 \ u60a3 \ u8005 \ u4e2d \ u6bd4 \ u5065 \ u5eb7 \ u5bf9 \ u7167 \ u7ec4 \ u663e \ u8457 \ u589e \ u52a0 \ u3002 \ u75c5 \ u4f8b \ u7ec4 \ u4e2d \ u7684 \ u5e73 \ u5747CIMT \ u4e3a0. 69 \ u00b10. 11 mm \ uff0c \ u5bf9 \ u7167 \ u7ec40. 51 \ u00b10. 07 mm \ u3002 \ u75c5 \ u4f8b \ u7ec4 \ u4e2d \ u5e73 \ u5747 \ u6c27 \ u5316LDL \ uff08EU/mL \ uff09 \ u4e3a39. 3 \ u00b134. 4 \ uff08 \ u4ece14. 4 \ u5230160 \ u7684 \ u8303 \ u56f4 \ uff09 \ u4e0e \ u5bf9 \ u7167 \ u7ec4 \ u768423. 9 \ u00b113. 4 \ uff0812 \ u81f370 \ u7684 \ u8303 \ u56f4 \ uff09 \ u76f8 \ u6bd4 \ u663e \ u8457 \ u5347 \ u9ad8 \ uff08P = 0. 02 \ uff0ct \ u68c0 \ u9a8c \ uff09 \ u3002 \ u5728 \ u6211 \ u4eec \ u7684 \ u7814 \ u7a76 \ u4e2d \ uff0c \ u6211 \ u4eec \ u53d1 \ u73b0 \ u03b2 \ u5730 \ u4e2d \ u6d77 \ u8d2b \ u8840 \ u60a3 \ u8005 \ u4e2d \ u7684MDA \ u6c34 \ u5e73 \ uff08nmol/mL \ uff09 \ u6bd4 \ u5bf9 \ u7167 \ u7ec4 \ u66f4 \ u9ad8 \ u3002 \ u75c5 \ u4f8b \ u7ec4 \ u4e2d \ u7684 \ u5e73 \ u5747MDA \ u4e3a10. 0 \ u00b13. 27 \ uff084. 41 \ u81f317. 48 \ uff09 \ uff0c \ u800c \ u5bf9 \ u7167 \ u7ec4 \ u4e3a6. 87 \ u00b14. 55 \ uff081. 5 \ u523017. 9 \ uff09 \ u3002 \ u6211 \ u4eec \ u7684 \ u7814 \ u7a76 \ u7ed3 \ u679c \ u8868 \ u660e \ uff0cCIMT \ u662f \ u03b2 \ u91cd \ u578b \ u5730 \ u4e2d \ u6d77 \ u8d2b \ u8840 \ u52a8 \ u8109 \ u7ca5 \ u6837 \ u786c \ u5316 \ u7684 \ u65e9 \ u671f \ u6807 \ u8bb0 \ u7269 \ u3002 \ u6c27 \ u5316 \ u5e94 \ u6fc0 \ u6807 \ u8bb0 \ u7269 \ u5728 \ u03b2 \ u91cd \ u578b \ u5730 \ u4e2d \ u6d77 \ u8d2b \ u8840 \ u60a3 \ u8005 \ u4e2d \ u4e5f \ u6709 \ u589e \ u52a0 \ uff0c \ u8102 \ u86cb \ u767d \ uff08a \ uff09 \ u663e \ u793a \ u51fa \ u4e0eCIMT \ u5448 \ u6b63 \ u76f8 \ u5173 \ u3002 \ u672c \ u7814 \ u7a76 \ u9488 \ u5bf9 \ u03b2 \ u91cd \ u578b \ u5730 \ u4e2d \ u6d77 \ u8d2b \ u8840 \ u4e2d \ u7684 \ u5404 \ u79cd \ u52a8 \ u8109 \ u7ca5 \ u6837 \ u786c \ u5316 \ u673a \ u5236 \ u3002".

Source link: https://doi.org/10.4081/thal.2016.4939


Increased Levels of Plasma Alzheimer’s Disease Biomarkers and Their Associations with Brain Structural Changes and Carotid Intima-Media Thickness in Cognitively Normal Obstructive Sleep Apnea Patients

. " Obstructive sleep apnea has been connected to Alzheimer \ u2019s disease and amyloid deposition in the brain. In this study, we assessed the plasma degrees of AD neuropathology biomarkers and their partnerships with structural changes of the brain and atherosclerosis. Thirty OSA patients with normal cognition and 34 normal controls were registered. Structural MR pictures of brain were gotten with voxel-based morphometric evaluation of T1 structural photos. The OSA patients exhibited considerably elevated plasma levels of A \ u03b2-42 and T-tau, as well as increased gray matter quantity in the right precuneus. ".

Source link: https://doi.org/10.3390/diagnostics12071522


Association between Carotid Intima-Media Thickness and the Use of Biological or Small Molecule Therapies in Patients with Rheumatoid Arthritis

. " Objective: The objective of this research study was to evaluate the association of carotid intima-media thickness, and additionally the existence of atheromatous plaque, with organic and targeted artificial disease-modifying antirheumatic drugs, in a well established cohort of patients with rheumatoid arthritis. Patients and Methods: We conducted a cross-sectional empirical study based on a cohort of patients with RA and a registry of healthy and balanced controls, in whom the CIMT and presence of atheromatous plaque were analyzed by ultrasound. Contrasted to values in patients on other therapies, the CIMT was smaller amongst patients on tumour necrosis factor alpha preventions and among those on Janus kinase inhibitors, while no differences were found as a function of the use of the other therapies considered. Verdicts: The use of TNF \ u03b1 inhibitors might safeguard versus subclinical atherosclerosis in patients with RA, patients on this biologic having smaller CIMTs than patients on other disease-modifying antirheumatic drugs. ".

Source link: https://doi.org/10.3390/diagnostics12010064


Impact of Mitochondrial DNA Mutations on Carotid Intima-Media Thickness in the Novosibirsk Region

. " The look for markers of predisposition to atherosclerosis advancement is very crucial for early recognition of individuals with a high risk of heart disease. The objective of the here and now research was to explore the association of mitochondrial DNA mutations with carotid intima-media thickness and to figure out the effect of mitochondrial heteroplasmy measurements in the diagnosis of atherosclerosis growth. It was shown that the mean cIMT correlated with the complying with mtDNA mutations: m. 15059G > A, m. 12315G > A, m. 5178C > A, and m. 3256C > T; a negative connection with mtDNA mutations m. 14846G > A and m. 13513G > A was observed. In the linear regression evaluation, the addition of the collection of mtDNA mutations to the conventional cardiovascular risk aspects increased the capability to predict the cIMT variability from 17 to 27%. ".

Source link: https://doi.org/10.3390/life10090160


Serum Osteoprotegerin and Carotid Intima-Media Thickness Are Related to High Arterial Stiffness in Heart Failure with Reduced Ejection Fraction

. " Circulating biomarkers have been related to AS; nonetheless, their value in heart failure is poorly characterized. Our aim was to assess the medical and biomarker correlates of AS in the setup of cardiac arrest with decreased ejection portion. In 78 hospitalized, hemodynamically stable patients with HFrEF, AS was gauged using aortic pulse wave speed. OPG and the OPG/RANKL proportion were significantly higher in the group of patients with increased PWV. OPG and cIMT were considerably related to PWV in the logistic regression models when changed for hypertension, EF, and the presence of atherosclerotic symptoms. ".

Source link: https://doi.org/10.3390/diagnostics11050764


What Can We Change in Diet and Behaviour in Order to Decrease Carotid Intima-Media Thickness in Patients with Obesity?

. " In our paper, we aimed to summarize the existing knowledge regarding IMT dimension among patients with obesity as a risk group \ u2014also in regards to the excessive weight mystery where the diagnosis of subclinical atherosclerosis is specifically essential and executes the early restorative approach. We also summed up behavioural, modifiable aspects, such as the Mediterranean diet regimen, the Dietary Approach to Stop Hypertension Diets, body weight reduction or the consumption of mini- and macronutrients, with a certain concentrate on the researches where the cIMT worths were one of the outcomes. ".

Source link: https://doi.org/10.3390/jpm11060505


Association of Glomerular Filtration Rate and Carotid Intima-Media Thickness in Non-Diabetic Chronic Kidney Disease Patients over a 4-Year Follow-Up

. " This possible research was conducted at University Clinical Hospital Mostar over a 4-year period and signed up an overall of 100 patients with phase 2 and 4 CKD. Phase 4 CKD group had dramatically higher standard CIMT worths, and more atherosclerotic plaques at the study onset compared to phase 2 CKD. A statistically considerable 4-year increase in GFR with non-significant CIMT alterations has been observed in phase 2 CKD. Finally, this research demonstrates significant association of GFR and CIMT in non-diabetic stage 2 and phase 4 CKD during the 4-year follow-up. ".

Source link: https://doi.org/10.3390/life11030204


Composite carotid intima-media thickness as a risk predictor of coronary heart disease in a selected population in Sri Lanka.

. " Background Segment-specific variations of carotid intima-media thickness have not been assessed in South Asian populations. If segment-specific CIMTs or a composite-CIMT score is a better risk predictor of coronary heart disease in South Asian populations, the purpose of this research study was to determine. Ultrasound exam of the common carotid, the carotid bulb and the interior carotid segments of the carotid vessels was carried out by a radiologist, and CIMTs were measured. The mean age of the research study example was 60. 2 years. The mean composite-CIMT value of the CHD group was considerably greater than that of the non-CHD group. A composite-CIMT rating of 0. 758 had a sensitivity of 98. 4% and uniqueness of 64. 6% in distinguishing CHD from non-CHD groups. The composite CIMT rating is better than segment-specific CIMTs in anticipating CHD and might be used to forecast CHD in this population. ".

Source link: https://doi.org/10.1371/journal.pone.0271986


Composite carotid intima-media thickness as a risk predictor of coronary heart disease in a selected population in Sri Lanka

. " Background Segment-specific variants of carotid intima-media thickness have not been analyzed in South Asian populations. The purpose of this research was to establish if segment-specific CIMTs or a composite-CIMT rating is a better risk predictor of coronary heart disease in South Asian populations. Ultrasound assessment of the common carotid, the carotid light bulb and the inner carotid sectors of the carotid vessels was carried out by a radiologist, and CIMTs were measured. The mean age of the study sample was 60. 2 years. The mean composite-CIMT worth of the CHD group was substantially higher than that of the non-CHD group. A composite-CIMT score of 0. 758 had a sensitivity of 98. 4% and uniqueness of 64. 6% in identifying CHD from non-CHD groups. The composite CIMT score is better than segment-specific CIMTs in forecasting CHD and might be used to predict CHD in this population. ".

Source link: https://doaj.org/article/a1614cb8981641bcaad51b9b74a27483

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions