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Carotid Atherosclerosis Progression - Crossref

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Last Updated: 03 November 2021

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Long non-coding RNA SNHG16 contributes to progression of carotid atherosclerosis by regulating miR-30c-5p/ADAM10 axis

Lengthy non-coding RNA little nucleolar RNA host genetics 16 could promote the development of atherosclerosis. The binding relationship between miR-30c-5p and lnc-SNHG16 or ADAM10 was anticipated by Starbase, after that confirmed by the dual-luciferase press reporter assay. ResultsLnc-SNHG16 and ADAM10 were boosted, and miR-30c-5p was reduced in CAS patient and oxidized low-density lipoprotein -treated human aortic smooth muscle mass cells. Mechanical evaluation confirmed that lnc-SNHG16 improved ADAM10 expression by sponging miR-30c-5p. ConclusionsOur data indicated that lnc-SNHG16 might control the progression of ox-LDL caused CAS model by the miR-30c-5p/ ADAM10 axis, implying a prospective healing strategy for CAS.

Source link: https://doi.org/10.5114/aoms/128012

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions