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Carotid Artery Stenosis - Crossref

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Last Updated: 03 October 2022

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The Clinical Significance of Lncrna GAS5 And Mir-222-3p in Carotid Artery Stenosis

Background: The primary cause of cerebral infarction and brain death is Carotid artery stenosis. In this study, the clinical value of lncRNA GAS5 and miR-222-3p in the diagnosis and prognosis of CAS was investigated to identify new useful biomarkers of CAS. PCR revealed that the expression levels of GAS5 and miR-222-3p in study subjects could be determined by PCR. Results: In CAS patients, the reduced expression of GAS5 and elevated expression of miR-22-3p was found in CAS patients relative to the healthy controls, and a significant correlation between their expression levels in CAS was discovered. With high sensitivity and specificity, GAS5 and MiR-222-3p could distinguish CAS patients from the healthy controls. The GAS5 downregulation and miR-222-3p upregulation may have predicted the poor prognosis of CAS patients and may be attributed to patient survival issues. MiR-222-3p could negatively influence the luciferase activity of GAS5 in human vascular smooth muscle cells.

Source link: https://doi.org/10.1532/hsf.4739


Contribution of Current Comorbid Conditions to Carotid Artery Stenosis in Patients Undergoing Coronary Artery Bypass and Stroke Distribution in Carotid Artery Stenosis Groups

Objective: This study was designed to contribute to the issue of u201d and preoperative CAS by investigating comorbid diseases in patients undergoing coronary artery bypass graft surgery and discussing the effects of carotid stenosis levels on postoperative strokes. The results of this, 594 CABG patients aged 60 and over who underwent preoperative carotid Doppler examination were investigated. The presence of left main coronary disease, 10. 9% with male sex, 3. 8 with chronic obstructive pulmonery disease, 8. 8% with the occurrence of persistent obstructive pulmonery disease, 3. 8 with male sex, 3. 8 with presence of persistent obstructive pulmonary disease, 3% with left main coronary disease, 2. 9 with presence of persistent pulmonary disease, 0. 9 with presence of persistent pulmonary disease, 0. 8 with presence of o s, In the 0-29% group, 4. 3 percent in the 5-9 percent group, and 11. 1% in the 70-99% group were 2. 1%, with 2. 9 percent in the 70-99% group. In ten patients who underwent carotid endarterectomy, CVA was not apparent, according to the Postoperative CVA. In six patients with 50% or more stenosis who did not complete CE, Postoperative CVA developed in six patients with stenosis with 50% or more who did not receive CE. We recommend that carotid screening be done in those over 65 years of age and with PAD+DM. To determine the effects of aortic atherosclerosis load, surgical intervention, and bilateral CAS presence in patients with high CAS and postoperative CVA, large populations are required.

Source link: https://doi.org/10.1532/hsf.3945


Predictive Value of Neutrophil-to-Lymphocyte, Aspartate-to-Alanine Aminotransferase, Lymphocyte-to-Monocyte and Platelet-to-Lymphocyte Ratios in Severity and Side of Carotid Artery Stenosis: Are Those Significant?

One of these arterial structures and occlusionless disease of carotid artery can cause stroke or cranial infarction. Tablelet-to-lymphocyte, neutrophil-to-lymphocyte, lymphocyte-to-monocyte, and aspartate-to-alanine aminotransferase ratios were among the study's goals. Methods: The study included one hundred-fifteen patients with carotid artery stenosis between 50%-99% and 115 healthy controls with no carotid artery stenosis or additional disease. In the patient group, the relationship between the patient and lesion -type, neutrophil-to-monocyte, lymphocyte-to-monocyte, and aspartate-to-alanine aminotransferase ratios were investigated. Patients with carotid artery stenosis and the healthy controls were compared, in terms of the same criteria. Conclusion: Platelet-to-lymphocyte, neutrophil-to-monocyte, lymphocyte-to-monocyte, and aspartate-to-alanine aminotransferase ratios are inexpensive, fast, and reproducible measurements that can be used to determine carotid artery stenosis prediction.

Source link: https://doi.org/10.1532/hsf.3431


Is External Carotid Artery Hemodynamics Helpful in Detecting Internal Carotid Artery Stenosis?

paraphrased artery stenosis by carotid duplex ultrasound scanning, there is a paucity of validated external carotid artery velocity standards and findings on the connection between ECA velocities and internal carotid artery stenosis. Our goals were to establish the correlations between ECA peak systolic velocity and percent stenosis seen on confirmatory imaging, as well as comparing ECA hemodynamics with well-known ICA disease by CDU. The mean PSV of the normal ECA cohort was 135. 3 u00b1 82. 1 cm/s, and the diseased ECA cohort's mean PSV was 279. 7 cm/s, according to the diseased ECA cohort. Although the results show a weak but statistically significant relationship between ECA PSV and degree of ICA stenosis, further research with a larger sample size and confirmation studies are required to determine ICA disease using ECA hemodynamics to identify ICA disease.

Source link: https://doi.org/10.1177/15443167221121663


Mediating roles of leukoaraiosis and infarcts in the effects of unilateral carotid artery stenosis on cognition

Patients with carotid artery stenosis have a tendency, and leukoaraiosis and infarcts have all been implicated in cognitive impairments. The severity of CAS distress was not limited to merely hinder specific cognitive domains, but also extended to cognitive function by ipsilateral infarcts, periventricular leukoaraiosis, and deep white matter leukoaraiosis. Left CAS had direct impacts on most cognitive domains, except for visual memory and buildingal skills, and had indirect impacts on other cognitive domains, including visual memory and buildingal skills, and psychomotor through infarcts. Right CAS only had negative direct impacts on visual memory, psychomotor, design fluency, and color processing speed, and it had indirect implications on visual memory, word processing speed, and color processing speed through ipsilateral infarcts. Following covariate change, the trends of direct and indirect cognitive effects remained unchanged.

Source link: https://doi.org/10.3389/fnagi.2022.972480


Transcatheter aortic valve replacement through the carotid artery in a 60-year-old man with aortic stenosis and chronic dialysis: a case report

Because of the complicated procedure, transcatheter aortic valve replacement in middle-aged patients with severe aortic stenosis and chronic hemodialysis has been a challenge in clinical practice. Following an in-depth analysis of the heart team and the patient, TAVR was chosen after an increased risk of open surgery due to chronic hemodialysis. Therefore, the left carotid route was chosen because of severe calcifications and tortuous iliofemoral arteries.

Source link: https://doi.org/10.32895/ump.mpr.6.3.s10


Optimizing the Ultrasound Image Quality of Carotid Artery Stenosis Patients via Taguchi’s Dynamic Analysis and an Indigenous Water Phantom

This research enhanced the ultrasound image of carotid artery stenosis using Taguchi dynamic analysis and an indigenous water phantom. According to Taguchiu2019s L18 orthogonal array, eighteen combinations of seven key elements of the ultrasound scan center were arranged. The best quality of ultrasound images for further clinical diagnosis was obtained by the highest value on 18 groups under study, resulting in high r2 and low u03b2 (standard deviation) values, as well as the highest quality of ultrasound images for the further clinical diagnosis. In Taguchiu2019s review, FOM exhibited more quality characteristics that were superior by nature to meet the practical needs in clinical diagnosis. The alternative choice in ultrasound scan optimization can be based on stenosis diameter variation from a different perspective that will be explored in the follow-up study.

Source link: https://doi.org/10.3390/app12199751


MRI Outcomes Achieved by Simple Flow Blockage Technique in Symptomatic Carotid Artery Stenosis Stenting

We wanted to determine the prevalence and clinical consequences of new ischemic lesions identified with diffusion-weighted-imaging-MRI in this study, as well as the clinical outcomes after carotid artery stenting using the simple flow blockage method. This is a retrospective analysis in which data extraction from a monocentric prospective clinical registry of consecutive patients admitted for symptomatic cervical stenosis or web is not available. Patients in Herein and beyond recovered from DWI-MRI before and within 48 h of CAS for symptomatic ICA stenosis or web. Thirty-three patients with new DWI-MRI ischemic lesions were symptomatic, while 30 patients were asymptomatic. By comparison to patients with a normal plaque using the univariate method, an increased incidence of new DWI-MRI lesions with or without ulceration was found on a new DWI-MRI plaque surface with or without ulceration. New ischemic lesions were found with DWI-MRI in less than half of this CAS cohort using the SFB method.

Source link: https://doi.org/10.3390/jpm12101564


Short- and Mid-Term Outcomes of Stenting in Patients with Isolated Distal Internal Carotid Artery Stenosis or Post-Surgical Restenosis

In this single-center retrospective study, Sixty-six patients with u226550% distal ICA stenosis were included. In two patients in the AS group and in two patients in the RES group, postprocedural neurological events were recorded. In the AS group, there were an in-stent restenosis percentage of u2265 percent, but not in the RES group. And seven patients in the RES group died within three patients in the AS group and seven patients in the RES group. The first neurological complication rate of stenting caused by distal ICA stenoses is normal.

Source link: https://doi.org/10.3390/jcm11195640


Identification of Metabolomics Biomarkers in Extracranial Carotid Artery Stenosis

It's still a challenge to identify carotid artery stenosis by biochemical means. Blood samples were collected 14 days after stroke onset without any acute disease. Hypertension, diabetes, smoking, and alcohol intake were all common, according to the study, but diastolic blood pressure, HDL-C, LDL-C, and cholesterol were lower in CAS patients than controls, requiring intensive medical intervention for CAS. PLS-DA and PCA, as well as PLS-DA, did not show any clear distinction between controls and CAS patients. According to the present study, metabolomics reports could aid in distinguishing between control and CAS patients and monitoring the progress of CAS.

Source link: https://doi.org/10.3390/cells11193022

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions