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In patients with substantial carotid stenosis who do not meet medical requirements for carotid endarterectomy, high resolution magnetic resonance imaging will be used to serially monitor the effects of Evolocumab on carotid plaque morphology and composition. Patients with symptomatic carotid stenosis will be able to benefit patients with Evolocumab therapy, according to the results of this review, which will determine whether or not treatment with Evolocumab is likely to be helpful to patients with asymptomatic carotid stenosis.
Source link: https://clinicaltrials.gov/ct2/show/NCT03931161
Atherosclerosis can be caused by the carotid bulb which is located upstream of the internal carotid artery origin. Carotid artery thrombosis or atherosclerotic plaque fragmentation, both of which may leak into the brain, is the risk of carotid stenosis. paraphrased artery origin obstruction rates are determined by a carotid stenosis catheter. An Echo-Doppler is used to determine the bulb and internal carotid artery origins. The reference system for determining carotid stenosis is based on hemodynamic criteria that only permit the diagnosis of high grade stenosis thresholds. With Doppler ultrasound, two methods of carotid stenosis morphological quantification are currently available. Calibre diminution at the maximum of stenosis can be determined by comparing the smallest luminal diameter to the vessel diameter at the stenosis site or downstream internal carotid artery diameter.
Source link: https://clinicaltrials.gov/ct2/show/NCT05437991
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