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Carotid Artery Occlusion - Springer Nature

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Last Updated: 05 September 2022

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Neuroprotective and Proneurogenic Effects of Glucosamine in an Internal Carotid Artery Occlusion Model of Ischemia

Given that clinical translation of therapeutic candidates in animal models of ischemic stroke has been largely unsatisfactory, perhaps due to the inadequacy of existing models, we sought to investigate the effects of glucosamine in a recently published, clinical condition mimicking mouse model of internal cerebral artery occlusion. Glucosamine increased the number of large neurospheres in ex vivo neurosphere assay involving neural stem cells/neural progenitor cells from subventricular zone, as well as increasing mRNA levels of the proliferation markers Nestin, NeuroD1, and Sox2.

Source link: https://doi.org/10.1007/s12017-021-08697-5


Time and Brain Region-Dependent Excitatory Neurochemical Alterations in Bilateral Common Carotid Artery Occlusion Global Ischemia Model

Neurochemical changes in cerebral ischemia can be caused by strictt metabolic regulation in discrete brain regions. One of the first neurochemical changes that occur during cerebral ischemia is accumulation of extracellular glutamate. Understanding the chemical pathways involved in cerebral ischemia-mediated excitotoxicity before and during the clinical intervention of revascularization and reperfusion may have a large effect on future therapeutic options for clinical stroke recovery. In the bilateral common carotid artery occlusion model of global ischemia, this research investigated the effect of time and brain regions on excitatory neurochemical indices. Male Wistar rats were exposed to BCCAO for 15 and 60 minutes to determine the effect of ischemia duration on excitatory neurochemical indices in the discrete brain regions. Excitatory neurotransmitters play a significant role in the tissue-specific metabolic plasticity and reprogramming that occurs between the onset of cardiac arrest-mediated global ischemia and clinical intervention of recanalization.

Source link: https://doi.org/10.1007/s11064-022-03732-8

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions