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Carotid Artery - Springer Nature

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Last Updated: 10 January 2023

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Infants with macrosomia and infants of diabetic mothers have increased carotid artery intima-media thickness in childhood

Incidence of diabetes during pregnancy is on the rise globally, and intrauterine hyperglycemia exposure may have long-term adverse effects on children's cardiovascular health. In 2021, we reviewed prospectively the possibility of atherosclerosis and carotid intima-media thickness in infants born macrosomic and in diabetic infants of diabetic mothers at the age of 8u20139 years. The study included a total of 49 infants of diabetic mothers and 13 macrosomic infants. They were compared to 26 age-matched healthy children with birth weight deemed suitable for gestational age born to non-diabetic mothers. In the IDM group, the concentration of high-density lipoprotein cholesterol was lower than that of the other groups. In the IDM group, exclusive and total breastfeeding was less frequent than in the control group. Conclusion : At 8u20139 years old age, CIMT values were higher in IDM and macrosomic groups at 8-u20139 years old age, compared to children born with normal birth weight. U2022 What is known: u2022 The intrauterine hyperglycemia exposure has long-term adverse effects on children's cardiovascular health, and is also detrimental to their cardiovascular health. At birth, diabetic mothers' infants have a higher carotid artery intima-media thickness at birth. Both infants of diabetic mothers and infants with macrosomia have an elevated carotid artery intima-media thickness at the age of 8 to 9 years. u2022 zoog 22 What is New: Both infants of diabetic mothers and infants with macrosomia have an elevated carotid artery intima-media thickness has increased at 8-9 years. u2022 Duration of breast feeding is very important, particularly in infants of diabetic mothers, because body mass index, skinfold thickness, waist to hip, and height ratio were all higher in those breastfed less than six months.

Source link: https://doi.org/10.1007/s00431-022-04653-y


Time and Brain Region-Dependent Excitatory Neurochemical Alterations in Bilateral Common Carotid Artery Occlusion Global Ischemia Model

Neurochemical changes in cerebral ischemia are the result of strictt metabolic regulation in discrete brain regions. Accumulation of extracellular glutamate is one of the first neurochemical changes that occur during cerebral ischemia. Understanding the intricate neurochemical pathways involved in cerebral ischemia-mediated excitotoxicity before and after surgical intervention could have a huge effect on future therapeutic strategies for clinical stroke rehabilitation. In the bilateral common carotid artery occlusion model of global ischemic artery occlusion, this study investigated the effects of time and brain regions on excitatory neurochemical indices. Male Wistar rats were exposed to BCCAO for 15 and 60 min to determine the effect of ischemia duration on excitatory neurochemical indices in the discrete brain regions. Excitatory neurotransmitters play a major role in the tissue-specific metabolic plasticity and reprogramming that takes place between the onset of cardiac arrest-mediated global ischemia and clinical intervention of recanalization.

Source link: https://doi.org/10.1007/s11064-022-03732-8


Non-stenosing carotid artery plaques in embolic stroke of undetermined source: a retrospective analysis

Background In the ESUS patient population, we want to determine the connection between high-risk carotid plaques and their latency to stroke. We analyzed plaque features that are associated with ESUS and subsequently identified the recurrent stroke events and characterized lateralization to the index stroke using computed tomography angiography. Out of 1779 patients with cryptogenic ischemic stroke, we included 152 patients who fulfilled the criteria for ESUS. When compared contralaterally: plaque ulceration 19. 08% vs. 5. 2 percent, p 3 mm, and plaque length > 1 cm were deemed more ipsilateral to the stroke side.

Source link: https://doi.org/10.1007/s10072-022-06425-w


Strategies to avoid internal carotid artery injury in “sandwich” atlantoaxial dislocation patients during surgery

Methods The distance between the ICA wall and the midsagittal plane of atlas on the most contiguous and cranial planes of LMA, as well as the angle between the sagittal plane passing through the entry point of the vessel passing through the entry point was measured. Results There was a statistically significant difference between the male and female patients regarding D1, and there was a statistically significant difference between D2 at level a and level b, as well as angle A between the left and right sides were statistically different. To describe the relationship between ICA and LMA, a novel description of ICA location was used.

Source link: https://doi.org/10.1007/s00701-022-05449-7


Serum from Stroke Patients with High-Grade Carotid Stenosis Promotes Cyclooxygenase-Dependent Endothelial Dysfunction in Non-ischemic Mice Carotid Arteries

Pro-inflammatory mediators in severe atherosclerosis may increase endothelial dysfunction after stroke contributing to impair disease outcomes. Environments of severe carotid atherosclerotic disease have exacerbated endothelial dysfunction in stroke, which has an elevated risk of more cerebrovascular events, according to We hypothesize. The findings reveal that serum from stroke patients resulted in an increase in acetylcholine relaxations in mice carotid arteries, indicating endothelium dysfunction. Patients were stratified according to their degree of stenosis, serum from HGS patients caused more severe carotid artery endothelial dysfunction, which was correlated with elevated circulating levels of IL-1u03b2. The present findings, however, contribute to the growing risk of stroke in atherosclerosis by targeting COX in the carotid artery wall, potentially a new therapeutic strategy for secondary stroke prevention.

Source link: https://doi.org/10.1007/s12975-022-01117-1


Dilated hypertrophic phenotype of the carotid artery is associated with accelerated age-associated central arterial stiffening

PWV's among older adults and men was significantly higher than those with normal CGP; those with dilated hypertrophy CGP had a much larger longitudinal increase in PWV. Future studies are required to see if this association mediates the increased risk of CVD seen in people with hypertrophic cardiac remodelling, as well as the role of delaying it to minimize this risk. Individuals with dilated hypertrophic geometric phenotypes of the common carotid artery have elevated central arterial stiffening in the future central arterial stiffening, regardless of other arterial stiffening determinants. u2022 Understanding the natural history of the carotid geometric phenotype throughout the lifespan and the determinants of the deleterious progression toward the dilated hypertrophic phenotype are needed to design interventions that reduce the adverse clinical outcomes associated with it.

Source link: https://doi.org/10.1007/s11357-022-00699-w

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions