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Moyamoya disease is a disease of blood vessels in the brain, specifically the internal carotid arteries and the arteries that branch from them. Blood flow in the brain is reduced by narrowing these vessels. Moyamoya disease typically begins around age 5 or in a person's thirties or forties. In addition, the fragile blood vessels that grow can bulges or crack open, resulting in bleeding in the brain. Symptoms that affected people may include frequent headaches, involuntary jerking activities, or a decrease in reasoning ability may contribute to a lack of cognition. If the disease is not addressed, the signs of moyamoya disease can often exacerbate over time. In comparison to other health disorders such as neurofibromatosis type 1 sickle cell disease or Graves disease, some people have moyamoya disease-related blood vessel changes typical of moyamoya disease. These individuals are thought to have moyamoya syndrome.
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