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Nepenthes are carnivorous pitcher plants that have many ethnobotanical uses, such as curing stomachache and fever. In this research, the leaf extract of N. miranda obtained by 100% acetone was used to determine the cytotoxic properties, antioxidation capacity, antibacterial activity, and allantoinase inhibitory effects of this plant. The following cells were demonstrated by N. miranda-leaf-acetone on the survival, apoptosis, and migration of the cancer cell lines PC-9 pulmonary adenocarcinoma, B16F10 melanoma, and 4T1 mammary carcinoma cells. Cells: B16F10 > 4T1 > PC-9 cells, based on gathered data. In addition, when working with the clinical anticancer drug 5-fluorouracil, the cytotoxic properties of N. miranda-leaf-acetone were synergistically enhanced. Regardless of inhibition of ALLase, a key enzyme in purine degradation's catabolism pathway, N. miranda-leaf-acetone's degradation, it can also inhibit the production of the enzyme ALLase, a key enzyme involved in purine degradation's catabolism pathway. Overall, these findings reveal that N. miranda's pharmacological potential can be used for further medical applications.
Source link: https://europepmc.org/article/MED/36079647
Both abiotic causes and mismatches with interacting species may be attributed to both abiotic causes and mismatches with interacting species. Methods We mixed results along a soil temperature gradient in a geothermically cooled area with pollen and prey supplementation experiments, discovering how phenotypic selection in Pinguicula vulgaris is dependent on soil temperature, pollen, and prey availability depends on soil temperature, as well as pollen and prey availability. Plant-pollinator mismatches may be a contributing reason why evolved plastic responses to rising spring temperatures are nonadaptive under new environmental conditions, as well as why there is a selection to delay flowering. In our research, later flowering pick remained after artificially raising pollen availability, indicating that abiotic factors may also play a role in the observed selection. Understanding and forecasting evolutionary responses to climate warming is vital in determining and forecasting evolutionary responses to climate change. Identifying the reasons that make evolved phenological responses maladaptive under novel conditions is critical to understanding and forecasting evolutionary responses to climate warming.
Source link: https://europepmc.org/article/MED/35971628
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