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The present experiment was conducted to determine the effects of tallow and crude soybean oil, with or without Lcarnitine supplementation on male broiler chicks' carcass and lipid profiles. The day old male broiler chicks were divided into four treatment groups, with eight replicates each having five birds each. Except for abdominal fat percentage, the fat sources with or without carnitine had no effect on various broiler carcass yields, except for abdominal fat percentage, although interactions between fat sources and carnitine were significant. Absent carnitine, crude soybean oil's abdominal fat content was significantly lower than that of crude soybean oil. With 12 h fasting, the Serum triglycerides and cholesterol levels were significantly lower for birds fed with tallow diet, whereas, the concentration of triglycerides and cholesterol with 3 h fasting was significantly lower for birds fed with tallow diet.
Source link: https://doi.org/10.56093/ijans.v88i5.79983
Autism Spectrum disorder and intellectual disability are two of the most common developmental disorders with a prevalence of between 3% and 5% of the population. Mutations in several genes that influence gene expression have been attributed to different IDs in KAT6A syndrome, such as mutations of the ly-acetyltransferase 6A gene. In mutant KAT6A cells, treatment with Pantothenate and L-carnitine enhanced histone acetylation and corrected protein and transcriptomic expression patterns. In addition, mutant cell energetics were greatly enhanced. In cell models of KAT6A syndrome, we find that pantothenate and L-carnitine can effectively correct the mutant phe-notype.
Source link: https://doi.org/10.20944/preprints202211.0273.v1
VLCAD deficiency findings in a sequence of anomalies include: one accumulation of long-chain acylcarnitines, 2 action potential shortening, 3 elevated systolic and diastolic intracellular Ca 2+ concentrations, and 4 cases of delayed postdepolarization. Carnitine is a fatty acid oxidation process that must be used for bidirectional transport of acyl groups across the mitochondrial membrane. Val283Ala/p. Glu381del: We investigated the effects of carnitine supplementation on the long-chain acylcarnitine levels and performed electrophysiological measurements in VLCADD patient-derived hiPSC-CMs with a ACADVL gene mutation. In medium and cells, the hiPSC-CMs incubation with 400 b5M L-carnitine for 48 h resulted in an elevated long-chain acylcarnitine level. We conclude that long-chain acylcarnitine accumulation and electrophysiological abnormalities in VLCADD hiPSC-CMs are not normalized by carnitine supplementation, indicating that this therapy is unlikely to be helpful to cardiac arrhythmias in VLCADD patients.
Source link: https://doi.org/10.3389/fphar.2020.616834
Mutations in several genes involved in gene expression epigenetic regulation of gene expression have been considered risk alterations to several autism spectrum disorder disorders related to autism spectrum disorder. We investigated the pathophysiological changes in fibroblasts isolated from three patients harboring KAT6A mutations in this paper. In mutant KAT6A cells, Pantothenate and L-carnitine treatment exacerbated histone acetylation and partially corrected protein and transcriptomic expression patterns. Moreover, mutant cell cellular bioenergetics were also greatly enhanced. Our findings show that pantothenate and L-carnitine will greatly enhance the mutant phenotype in cell models of KAT6A syndrome.
Source link: https://doi.org/10.3390/genes13122300
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