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Carnitine Deficiency - PubAg

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Last Updated: 16 October 2021

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Prevalence of Carnitine Deficiency and Decreased Carnitine Levels in Patients on Peritoneal Dialysis

Lotion free carnitine concentration is considerably lower in patients on hemodialysis than in healthy people. There are few reports on product free carnitine focus in patients on peritoneal dialysis. Methods: We analyzed serum concentrations of total amount, free, and acylcarnitine and the acylcarnitine/free carnitine ratio in 34 PD and 34 age-, sex-, and dialysis duration-matched HD patients. We examined the prevalence of carnitine deficiency and scientific aspects related to carnitine deficiency in the PD group. Conclusions: The prevalence of carnitine deficiency, high risk of carnitine deficiency, and carnitine insufficiency in PD patients was 8. 8%, 73. 5%, and 82. 3%, specifically.

Source link: https://pubag.nal.usda.gov/catalog/6770911


Sudden infant death from neonate carnitine palmitoyl transferase II deficiency

A full-term female child born to moms and dads who delivered 3 years before a woman that endured just 31h postpartum passed away 36h after birth. Tandem mass spectrometry evaluation disclosed that the deceased client had a carnitine palmitoyl transferase II deficiency or a carnitine-acylcarnitine translocase deficiency. Genetic screening of the moms and dads exposed heterozygous CPT2 mutations, indicating that their offspring would have a 25% chance of having a CPT2 deficiency.

Source link: https://pubag.nal.usda.gov/catalog/5703316


Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias: A hypothesis

That brain carnitine deficiency might cause autism is suggested by records of severe carnitine deficiency in autism and by proof that TMLHE deficiency − a problem in carnitine biosynthesis − is a danger factor for autism. A genetics on the X chromosome likely gets away arbitrary X‐inactivation and can limit carnitine transport throughout the blood‐brain obstacle in children compared to girls.

Source link: https://pubag.nal.usda.gov/catalog/5762912


Urinary 3-hydroxyisovaleryl carnitine excretion, protein energy malnutrition and risk of all-cause mortality in kidney transplant recipients: Results from the TransplantLines cohort studies

Since muscular tissue losing is a major danger element for mortality in kidney transplant receivers, nutritional leucine intake may be connected to long-lasting death. Urinary 3-hydroxyisovaleryl carnitine excretion, a practical pen of low biotin deficiency, might offer as a pen for nutritional leucine intake. In this study we intended to investigate the cross-sectional components of urinary system 3-HIC discharging and to prospectively examine the organization of urinary 3-HIC excretion with all-cause mortality in KTR. Urinary 3-HIC discharging and plasma biotin were measured in a longitudinal mate of 694 secure KTR.

Source link: https://pubag.nal.usda.gov/catalog/7134138


Differential effects of dietary Cu deficiency and excess on carnitine status, kinetics and expression of CPT I in liver and muscle of yellow catfish Pelteobagrus fulvidraco

The here and now study was performed to identify the effect of dietary Cu deficiency and extra on carnitine condition, kinetics and expression of CPT I in the liver and muscle mass of adolescent yellow catfish Pelteobagrus fulvidraco. Contrasted to the sufficient Cu team, nutritional Cu deficiency did not substantially influence the Vmax and Kilometres values, and the proportion of Vmax/Km in the liver and muscle. The mRNA expression of CPT Iα1a, CPT Iα1b, CPT Iα2a and CPT Iβ in the liver and muscle was affected by dietary Cu levels. To our expertise, today study offered, for the first time, proof that dietary Cu deficiency and excess differentially affected carnitine standing, kinetics and expression profiles of CPT I of yellow catfish, which would extend our understanding on Cu nutrition in fish.

Source link: https://pubag.nal.usda.gov/catalog/5539100


Effect of l-carnitine supplementation on muscle cramps induced by stroke: A case report

Nocturnal leg cramps appeared in the damaged side and caused rest disruption. Supplements with l-carnitine reduced the variety of nocturnal leg cramps and reduced rest disruption. Patients with stroke-induced paralysis experience muscular tissue throwing away, which could minimize pooled carnitine in the affected side. This case recommends that stroke may trigger local carnitine deficiency, and l-carnitine supplementation may be efficient for muscular tissue cramps induced by stroke. To the most effective of our understanding, this is the first case of l-carnitine supplementation for muscular tissue cramps caused by cerebral infarction.

Source link: https://pubag.nal.usda.gov/catalog/6762025


The Importance of the Fatty Acid Transporter L-Carnitine in Non-Alcoholic Fatty Liver Disease (NAFLD)

The value of L-carnitine in liver health is supported by the observation that patients with key carnitine deficiency can provide with fatty liver disease, which could be due to low levels of intrahepatic and product levels of L-carnitine. Studies that show reduced intrahepatic fat and lowered liver enzymes after L-carnitine supplementation suggest that L-carnitine might be a promising supplement to postpone the progression or boost of NAFLD.

Source link: https://pubag.nal.usda.gov/catalog/7078981


Selenium and L-Carnitine Ameliorate Reproductive Toxicity Induced by Cadmium in Male Mice

This study was carried out to check out the possible protective duty of Selenium and L-carnitine against the damaging impacts induced by Cd on the male reproductive system in mice. Treatment with Se and LC has the extremely synergistic and alleviates the harmful result of Cd on the testis via the elevation of the chemical anti-oxidant and decrease histopathological abnormalities and DNA damage.

Source link: https://pubag.nal.usda.gov/catalog/7070968


Effects of l-Carnitine Supplementation in Patients Receiving Hemodialysis or Peritoneal Dialysis

Total carnitine serum focus, free carnitine, and acylcarnitine substantially enhanced after oral l-carnitine treatment for 12 months, and after intravenous l-carnitine shot. There was no considerable enhancement in muscle convulsions, although reduced muscle cramping after l-carnitine treatment was reported by 31% of patients who had undertaken HD for > 4 years. Consequently, l-carnitine might work for lowering muscle mass cramping and boosting hemoglobin degrees in dialysis patients, specifically those that have been going through dialysis for > 4 years.

Source link: https://pubag.nal.usda.gov/catalog/7189762


Differential effects of dietary Zn deficiency and excess on carnitine status, kinetics and expression of CPT I in yellow catfish Pelteobagrus fulvidraco

Today research was performed to establish the result of nutritional Zn deficiency and extra on carnitine condition, kinetics and expression of CPT I in the liver and muscle mass of yellow catfish Pelteobagrus fulvidraco. Zn deficiency additionally minimized Kilometres and Vmax values while Zn unwanted increased them in the liver and muscle. Zn deficiency and excess influenced the expression degrees of four CPT I isoforms, such as CPT Iα1b, CPT Iβ, CPT Iα2a and CPT Iα1a in the liver and muscle. Furthermore, some correlations were observed in between the expression degrees of CPT I isoforms and Km for carnitine, and between CPT I isoform expression and CPT I activity. Hence, for the first time, our research indicated that Zn deficiency and unwanted showed differential results on carnitine standing, kinetics and expression of CPT I in yellow catfish, which assisted offer some novel understandings into Zn nutrition and toxicology in fish.

Source link: https://pubag.nal.usda.gov/catalog/5323062

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions