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Due to SARS-CoV-2 infection, a 60-year-old man was admitted to the intensive care unit for a rapid respiratory failure. On day 8, enteral feeding was started. The patient became increasingly unresponsive on day 85 in the ICU on day 85. The plasma-free carnitin level was low, as well as copper. Prolonged CRRT may be complicated by a clinically impaired supply of micronutrients and trace elements.
Source link: https://europepmc.org/article/MED/36035086
From a healthy control line, carrying a complete OCTN2-knockout and a homozygous OCTN2-defective human stem cell lines were established, resulting in two OCTN2-defective human stem cell lines. In contrast to isogenic control, OCTN2-defective genotypes demonstrated lower cardiac differentiation, lower force development, and longer steming length in engineered heart tissue culture. Ferroptosis, an iron- and lipid-dependent cell death pathway related to fibroblast activation, is a new PCD cardiomyopathy disease path.
Source link: https://europepmc.org/article/PPR/PPR531003
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