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Pediatric cancer survivors, particularly those who are asymptomatic, are concerned with late-onset cardiovascular disease. We investigated whether cardiopulmonary exercise testing could help to define the underlying pathophysiology of PCs' preclinical cardiovascular abnormalities. Peak oxygen consumption, peak work rate, and ventilatory anaerobic threshold were all significantly lower in PCS than controls, compared to controls, though peak heart rate and ventilatory results were similar. Despite improved ventilatory quality, Twelve PCs with higher peak RER displayed lower pVO2 and VAT than the rest of PCs, indicating a fundamental deficiency in oxygen utilization in some PCs.
Source link: https://europepmc.org/article/MED/36076098
Background: In people with heart disease, few studies have investigated the relationship between risk factors, physical fitness, and sedentary behavior in people with heart disease. Methods The hospital-based phase II cardiac rehabilitation patients with coronary heart disease were evaluated at the beginning and end of cardiac rehabilitation, 6 and 12-months. An association was found between higher MVPA and lower high density lipoprotein at a higher rate. No significant links were established between sedentary behavior variables and other outcomes. Low MVPA was linked to decreased SBP, but increased LIPA was correlated with reduced waist circumference and body mass index, while lower MVPA was related to reduced waist circumference and body mass index. Increased LIPA was linked to improved measures of adiposity, according to improved indicators of adoposity, though breaking up sedentary habits and raising MVPA could reduce SBP over time. In cardiac rehabilitation attendees, further investigation of MVPA, LIPA, and the dissemination of sedentary behavior has been suggested to investigate risk factors.
Source link: https://europepmc.org/article/MED/36071477
Regular exercise that meets or exceeds the new physical fitness standards is associated with a reduced risk of cardiovascular disease and mortality. These patients with CVDs have an elevated risk of cardiovascular disease and healthful clinical outcomes, with special attention on the appropriate mode, dosage, duration, and intensity of exercise to reduce CVD risk and improve clinical outcomes.
Source link: https://europepmc.org/article/MED/36075680
Exercise training has long been touted as a healthy lifestyle as well as a dependable non-drug therapeutic strategy for cardiovascular disease. Functional and mechanistic research using animal exercise simulation software as well as observational and interventional cohort studies with human subjects have all played a key role in delineating the key signaling pathways by which exercise improves cardiovascular fitness and wellbeing. This report summarizes the positive results of exercise on numerous aspects of cardiovascular health. Exercise-induced physiological cardiac hypertrophy may cause myocardial injury and cardiac remodeling, according to the signaling molecules that are vital for exercise-induced physiological cardiac hypertrophy. As well as the cross talk between the heart and other organs during exercise, we also discuss several factors that influence exercise's behavior and emphasize the need and desire for further research into the exercise-regulated molecules as therapeutic goals and biomarkers for CVD.
Source link: https://europepmc.org/article/MED/36050310
Maximal VO 2 is not feasible in a supine position, and standardizing subordinate exercise intensities is still difficult. A viable alternative to VO2-based submerged exercise intensities could be using heart rate or workload. Aim To translate subcutaneous cycling exercise into supine push-pull exercise by comparing heart rate or workload measured during UCE, with heart rate and workload during SPPE at similar exercise intensities. Methods and results 16 healthy young adults underwent cardiovascular UCE and SPPE testing were screened. During SPPE, the VO 2/Workload relationship became exponential and less effective relative to UCE. Conclusions Heart rate during UCE exercise intensities at suboptimal exercise intensities can also be used to support SPPE in healthy participants. Individual exercise intensity has to be considered during clinical evaluation of exercise CMR.
Source link: https://europepmc.org/article/MED/36036156
In adolescents with overweight and obesity, the aim was to investigate the effects of various physical exercise regimens and polymorphisms of the FTO on body composition and cardiovascular risk factors. Improvements in glycemia and total cholesterol as a result of the aerobic program, as well as a decrease in body fat mass were found. Patients with the risk allele A inherited the condition allele A glycemia was reduced by a weight training program. Cameron's stage four sexual maturation participants were 2. 1 times more likely to lose their body fat. With risk allele A, aerobic exercises resulted in a drastic reduction in fat mass and total cholesterol in patients with risk allele A. Distinct physical fitness regimens can result in a variety of risk factors related to adolescents' health.
Source link: https://europepmc.org/article/MED/36030815
In comparison to healthy individuals, we investigated how fitness and CV response to exercise as well as their association with PAD in CGL. Twelve CGL and 12 healthy controls were matched for age and gender, as well as 12 healthy subjects. CGL participants' baseline walked distance and increased heart rate, systolic, and diastolic pressures were reduced relative to healthy controls, with reduced predicted walked distance and increased heart rate, as well as diastolic and diastolic pressures. The majority of CGL patients had normal ABI values. The ABI and blood pressure were unchanged 12 months after the meterleptin replacement, but they walked a higher 6MWD than baseline. CGL subjects were also positively correlated with 6MWD and right ABI measurements. Conclusions We discovered that CGL subjects had reduced functional endurance and increased cardiovascular endurance for similar to 6MWT's success, indicating that exercise efforts for decreasing exercise intensity in this population should be vital. In addition, improved physical fitness was associated with CGL's high ABI.
Source link: https://europepmc.org/article/MED/36008763
In response to the exercises, we wanted to investigate in RA patients with CVD risk: the effectiveness of moderate to high-intensity aerobic exercises, potential changes in cardiovascular fitness and disease risk, as well as CVD risk factors. According to the Dutch Systematic Coronary Risk Evaluation, single-arm pilot-exercise intervention study included 26 consecutive patients with > 4% 10-year risk of CVD mortality over a 10-year period. Conclusions A 12-week exercise program seems to be safe and increases cardiorespiratory endurance and disease risk in patients with RA with a high risk of cardiovascular diseases. Patients with elevated cardiovascular disease risk were able to complete a maximum exercise test and a 12-week aerobic-based medium-to-high intensity exercise intervention, according to a Rheumatoid arthritis patients with elevated cardiovascular disease risk. Patients with elevated cardiovascular disease risk in rheumatoid arthritis patients with elevated cardiovascular risk increased cardiorespiratory fitness and disease risk as a result of the exercise intervention.
Source link: https://europepmc.org/article/MED/36006555
A systematic review of the effects of acute and chronic exercise in hypoxia on cardiovascular and glycemic variables in patients with type 2 diabetes. Hypoxia exercise has been suggested as a potential therapeutic intervention to promote angiogenesis and increase glucose metabolism in patients with type 2 diabetes who have normoxia. The inclusion criteria were as follows: Random and nonrandomized trials in complication-free patients with T2D in which EH was compared to normoxia or baseline results, which were then published in English. Conclusion: Acute EH improves glucose homeostasis in T2D patients, which was not seen with persistent EH. Both acute EH and chronic EH enhance angiogenesis regulators, but not vascular function. Given the supposed benefits of EH in patients with T2D, the results are still weak, and further study is required before recommendations can be made.
Source link: https://europepmc.org/article/MED/36036723
These epigenetic mutations can change genetic function under influence of exogenous stimuli and can be carried to the next generation, providing a potential mechanism for behavioral intervention effects inheritance. Exercise and nutritional advice in CVD's primary and secondary prevention of CVD are well known, but the mechanisms are not fully understood. We also highlight recent advancements in epigenetic therapy, which have ramifications for primary and secondary CVD prevention.
Source link: https://europepmc.org/article/MED/35989414
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