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Cardiovascular - Springer Nature

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Last Updated: 22 January 2023

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Cardiovascular disease risk factors and lifestyle modification strategies after pediatric kidney transplantation: what are we dealing with, and what can we target?

Kidney transplantation in pediatric patients can lead to partial improvement of some of the cardiometabolic variables that raise the risk of cardiovascular disease in patients with chronic kidney disease. This educational report explores the prevalence of CVD risk factors in pediatric kidney transplant recipients and highlights available evidence for lifestyle changes and other non-pharmacologic interventions that can be used to enhance traditional and modifiable CVD risk factors.

Source link: https://doi.org/10.1007/s00467-022-05589-z


Incidence of cardiovascular disease and mortality in childhood solid organ transplant recipients: a population-based study

Background: With increased longevity among children after transplantation, our knowledge of the risk of developing other comorbidities is expanding, but little is known about the long-term danger of cardiovascular events and mortality after solid organ transplantation. Methods In a cohort study using health administrative data, we compared cardiovascular events in children with liver, lung, kidney, small bowel, or multi-organ transplant at the Hospital for Sick Children, Toronto, Canada, with asthmatic children aged between 1996 and 2014. Within healthy organ transplant recipients than non-transplanted children, non-fatal event cardiovascular events were 34 times higher among solid organ transplant recipients than non-transplanted children. Conclusions: The increase in the incidence of cardiovascular events in children after transplantation highlights the need for surveillance during transition into adulthood and beyond. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary data.

Source link: https://doi.org/10.1007/s00467-022-05635-w


Cardiovascular Event Rates in Statin-Treated Korean Patients with Cardiovascular Disease: Estimates from a Real-World Population Using Electronic Medical Record Data

Objectives in an international population of very high risk Korean patients with prior myocardial infarction, ischemic stroke, or symptomatic peripheral artery disease may have been present in a symptomatic peripheral arterial disease, as described in the Further cardiovascular OUtcomes The goal of this research is to determine the danger of recurrent cardiovascular events in patients with elevated Risk trials participants. Methods This retrospective review examined the Asan Medical Center Heart Registry database, which is based on electronic medical records from 2000 to 2016. Patients with a history of clinically observable atherosclerotic cardiovascular disease with various risk factors were followed for three years. Patients with extremely high risk of cardiovascular disease in 3 years, according to our findings, we discovered that patients with a high risk of cardiovascular disease in Korea are at a substantial risk of more cardiovascular events in 3 years.

Source link: https://doi.org/10.1007/s10557-021-07255-2


Association between prevalence of laxative use and history of bone fractures and cardiovascular diseases in patients with chronic kidney disease: the Fukuoka Kidney disease Registry (FKR) study

Background Constipation is a common complication among patients with chronic kidney disease, and it plays a role in dysbiosis and CKD formation. Methods We conducted a cross-sectional review of 3878 patients with CKD using the Fukuoka Kidney Disease Registry's baseline data as a multicenter, prospective cohort study of pre-dialysis CKD patients. The key findings were the histories of bone fractures and cardiovascular diseases as signs of bone vascular disease disorders of the bone u2013cardiovascular axis. Patients with laxatives had significantly higher odds of bone fractures and CVDs than those without laxatives, according to a multivariable-adjusted logistic regression study [adjusted odds ratios 1. 67 and 1. 70, respectively, P 0. 05]. Conclusions These results show that constipation caused by laxative use in pre-dialysis patients with CKD are increasing prevalences of historical bone fractures and CVDs.

Source link: https://doi.org/10.1007/s10157-022-02289-8


Branched-chain amino acids in cardiovascular disease

McGarrah and White review the key factors that influence branched-chain amino acid abundance and metabolic fate, highlight molecular mechanisms linking impaired BCAA homeostasis to cardiovascular disease, and examine epidemiological evidence connecting BCAAs to various cardiovascular disease states. We review the latest evidence relating to cardiovascular disease and metabolic fate, highlight molecular mechanisms regulating BCAA homeostasis to cardiovascular disease, highlight emerging knowledge gaps that need further investigation. The roles of tissue-specific BCAA metabolism and inter-organ BCAA metabolic crosstalk in several CVD states, as well as the role of impaired BCAA metabolism in cardiovascular function and atherosclerosis, are among the areas for future research.

Source link: https://doi.org/10.1038/s41569-022-00760-3


Sulfide regulation of cardiovascular function in health and disease

Hydrogen sulfide has emerged as a gaseous signalling molecule with vital implications for cardiovascular health. Various preclinical and clinical studies have reported that H_2S and its synthesizing enzymes, including arrhythmias, atherosclerosis, heart disease, myocardial infarction, and ischaemia can prevent cardiovascular disease and ischaemia in the United States. H_2S and its metabolites, such as hydropersulfides and polysulfides, are markedly reduced in cardiovascular disease, and single-nucleotide polymorphisms in H_2S synthesis enzymes have been shown to be significantly reduced in cardiovascular disease. Hydrogen sulfide is a gaseous signalling molecule with important roles in cardiovascular health and disease. Hydrogen sulfide plays a key role in cardiovascular function; reduced bioavailability is linked to cardiovascular disease, heart failure, ischaemic myocardial dysfunction, and peripheral vascular disease; According to clinical findings, H_2S and its metabolites, including hydropersulfides and polysulfides, have potent therapeutic potential for various forms of cardiovascular disease.

Source link: https://doi.org/10.1038/s41569-022-00741-6


The Function and Therapeutic Potential of Circular RNA in Cardiovascular Diseases

CircRNAs contain microRNA binding sites, which can bind miRNAs and inhibit miRNA function. CircRNAs are potential biological diagnostic tools and therapeutic targets for cardiovascular diseases. We review the biogenesis, biology, analysis, and functions of circRNAs in CVDs, in the hopes that this information will contribute to CVD prevention and treatment.

Source link: https://doi.org/10.1007/s10557-021-07228-5


Association between serum alkaline phosphatase and cardiovascular events in patients with atrial fibrillation

The incidence rate of each group's incidence rate was determined, and the risks of cardiovascular events and each component for patients in the middle and high ALP tertiles were compared to those in the low tertile and assessed using Cox regression models. By receiver operating characteristic curve analysis, the extra predictive value of the high ALP tertile over the existing risk scores for the components of cardiovascular events was determined. The highest incidence rates of heart disease and other cardiovascular event components of each ALP group were similar in both ALP groups. The high ALP tertile lacked significant additive predictive value over the existing risk scores, according to a By ROC curve analysis for heart failure admission. Even those in the normal range, elevated serum ALP levels, especially heart failure admission in patients with AF, was strongly linked to an elevated risk of cardiovascular events, particularly heart failure admission in patients with AF.

Source link: https://doi.org/10.1007/s00380-022-02142-8

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions