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Cardiotoxicity Rats - Crossref

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Last Updated: 03 September 2022

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Rosiglitazone Does Not Show Major Hidden Cardiotoxicity in Models of Ischemia/Reperfusion but Abolishes Ischemic Preconditioning-Induced Antiarrhythmic Effects in Rats In Vivo

We used adult rat cardiomyocytes, AC16, and differentiated AC16 human cardiac cell lines to investigate the direct effects of rosiglitazone on cardiomyocytes. Rosiglitazone enhanced cell survival of ARCMs at 0. 3 %u03bcM. Roglitazone improved cell survival of AC16s but not those of diffAC16s, at 0. 1 and 0. 3 % u03bcM. In myocardial I/R injury models, this is the first demonstration that chronic rosiglitazone use does not result in significant hidden cardiotoxic effects. However, the inhibition of the antiarrhythmic effects of IPC may have some medical significance that needs to be investigated further.

Source link: https://doi.org/10.3390/ph15091055


Danhong injection attenuates doxorubicin-induced cardiotoxicity in rats via suppression of apoptosis: network pharmacology analysis and experimental validation

Doxorubicin is a potent chemotherapeutic agent used against various types of human malignancies. The Danhong injection is a Chinese drug with multiple pharmacological uses and is widely used for treating cardiovascular disease. The purpose of the present study was to determine the probable protective effects of DHI on vivo and attribute heart disease as well as the potential root mechanisms. To determine the therapeutic effects of DHI, a DOX-induced chronic cardiotoxicity rat model was established in Then, a DOX-induced chronic cardiotoxicity rat model was developed. Lastly, experimental findings revealed that DHI therapy significantly raised the Bcl-2 level and stifled DOX-induced Bax and caspase-3 expression in rat heart tissue. In addition, DHI therapy reduced the apoptosis risk of DOX-treated H9c2 cells. These findings show that DHI reduced DOX-induced cardiotoxicity by regulating the apoptosis pathway. DHI, according to the current report, is a promising agent for the prevention of DOX-induced cardiotoxicity.

Source link: https://doi.org/10.3389/fphar.2022.929302


Ameliorative effects of Artemisia and Echinacea extracts against hepato and cardiotoxicity induced by DMBA on albino rats: experimental and molecular docking analyses

Abstract: Herbal therapy for disease has many benefits over pharmaceutical drugs. This research suggested the enhancing effect of Ech and Art due to their antioxidant properties, but Ech and Art were more effective if they were administered before than after the DMBA's intervention and the marked reduction in DMBA toxicity with Ech before DMBA exposure. Moreover, the molecular docking, molecular properties descriptors, and pharmacoinformatic analysis of constituents of extract from Artemisia annua L. and Echinacea purpurea L. showed that all tested compounds have improved ADMET and physicochemical characteristics, particularly compounds extracted from Echinacea purpurea L. 's Granular Abstract.

Source link: https://doi.org/10.1186/s43088-022-00286-0


Intralipid fails to rescue bupivacaine-induced cardiotoxicity in late-pregnant rats

Cardiotoxicity and cardiac arrest can be caused by an accidental overdose of bupivacaine. In non-pregnant and late-pregnant female rats, bupivacaine cardiotoxicity and ILP rescue have yet to be investigated. Here, we tested the possibility that an appropriate dose of ILP may protect non-pregnant and late-pregnant rats from bupivacaine-induced cardiotoxicity. Non-pregnant and late-pregnant female rats were given intravenous bupivacaine to cause asystole. All rats had cardiac arrest within a few seconds after bupivacaine, and they died within a few seconds after bupivacaine. At 10-min post ILP with a HR of 70 % vs. 68 % at baseline vs. 39 4%, ILP rescued all non-pregnant rats with a VS of 81 bpm at baseline vs. 40 percent vs. 40 percent vs. 39 4% vs. 39 % vs. 39 % vs. 39 4% vs. 40 bpm, vs. Baseline HR, LVEF, and LVFS for late-pregnant rats were 330 bpm, 66 bpm, 38 %, respectively, with a range of 440 bpm, 65%, and 38 4%.

Source link: https://doi.org/10.3389/fmed.2022.899036


Doxycycline Attenuates Doxorubicin-Induced Cardiotoxicity by Improving Myocardial Energy Metabolism in Rats

We divided male Wistar rats into four groups: control, doxorubicin, doxycycline, and Dox + doxycycline. Doxycycline was used by Groups IM and DIM for four weeks once a week for four weeks. Doxorubicin promotes left atrium and left ventricle dilatation, as well as reductions in LV fractional shortening, which were aided by doxycycline. In addition, doxycycline attenuated the LV cardiomyocyte hypertrophy and collagen type I expression, as well as collagen type I. Doxorubicin raised phosphofructokinase and decreased beta-hydroxyacyl Co-A dehydrogenase, pyruvate dehydrogenase, citrate synthase, citrate synthase, and ATP synthase production, which was partially reduced by doxycycline. In the final, doxycycline improved antioxidant enzyme production in the DIM group.

Source link: https://doi.org/10.3390/jcdd9080254


Kolaviron and Garcinia kola attenuate doxorubicin-induced cardiotoxicity in Wistar rats

Results of pre-treatment with Kolaviron orally with Kolaviron showed a significant rise in heart rate and prolonged QT, reduced antioxidant status, increased physical strain, inflammation, and indicators of cardiac disease, which were not reversed by pre-treatment with Kolaviron.

Source link: https://doi.org/10.1515/jcim-2016-0168

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

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* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions