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Objective The SGLT2 inhibitor, canagliflozin, not only reduces glycemia in patients with type 2 diabetes, but also has cardioprotective properties in people without diabetes. In vivo, the aim of this research was to investigate the protective effect of canagliflozin pretreatment on postresuscitation-induced cardiac dysfunction. Methods Male C57/BL6 mice were randomly assigned to either vehicle or canagliflozin therapy groups. After resuscitation, canagliflozin-pretreated mice had a higher survival rate, a shorter return of spontaneous circulation time, and a higher neurological score than control mice. Canagliflozin was a good tool in reducing cardiac arrest and resuscitation-related cardiac dysfunction, as shown by an elevated left ventricular ejection percentage and fractional shortening. Canagliflozin is a canagliflozin derivative that promoted cardiac STAT-3 postresuscitation phosphorylation. In addition, canagliflozin's cardioprotective activity was suspended by pharmacological inhibition of STAT-3 by Ag490. Canagliflozin had a significant cardioprotective role against cardiac arrest and resuscitation-induced cardiac dysfunction in patients.
Source link: https://europepmc.org/article/MED/36609949
Background This report was published in China and sought to determine the survival rates of patients with out-of-hospital cardiac arrest patients undergoing cardiopulmonary resuscitation. In addition, the bystander CPR rate in patients with bystander CPR was significantly higher than that of those without, and the pooled odds ratio was 7. 92. Participants who started CPR within 5 min were significantly higher than those who started CPR after 5 min, and the pooled OR was 5. 92. The pooled OR was 8. 52 %, and the ROSC rate of participants with defibrillation was much higher than that of those without defibrillation, according to ROSC. Conclusion: The survival rates of out-of-hospital CPR in China are much lower than that of the global average. Thus, the aim of installing automated external defibrillators in public places and improving CPR education for healthcare professionals and public servants should be promoted and disseminated nationally.
Source link: https://europepmc.org/article/MED/36600249
Pre-cardiopulmonary arrest signs can be related to a medical disorder that results in a circulatory and respiratory system disruption, and can be caused by systemic and respiratory system dysfunction. The aim of this study was to determine the incidence of an event that resulted in pre-cardiopulmonary arrest signs within the first 24 h and then analyze the contributing factors affecting the health care services environment in critical post-general surgery patients in the intensive care unit. The patient factors associated with high pre-CA arrest sign scores were those from 18-40 years, with an operation status as emergency surgery, elective surgery, compared to urgent surgery, and the coordination of operation status and age in critical post-general surgery patients. Critical care services delivery should be delegated to nurses with nurse allocation and critical care nursing education to enhance quality of care for critical post-general surgery patients.
Source link: https://europepmc.org/article/MED/36613197
Pre-cardiopulmonary arrest signs can be due to a critical condition in the body that leads to a circulatory and respiratory system disruption. This study was designed to determine the incidence of an event leading to pre-cardiopulmonary arrest signs within the first 24 h and analyze the factors affecting the health care system in critically ill patients in the intensive care unit. The patient factors associated with high pre-CA arrest sign scores in critical post-general surgery patients were 18 to 40 years old, with an operation status as emergency surgery, elective surgery versus urgent surgery, and the interaction of operation status and age in critical post-general surgery patients. Critical care services delivery should be delegated to nurses with nurse allocation and critical care nursing training to enhance quality of care for acute post-general surgery patients.
Source link: https://europepmc.org/article/MED/PMC9819579
The aim of this research is to investigate the effects of patients treated with ECPR following refractory OHCA and IHCA. Methods This single-center, retrospective cohort study was carried out on patients with refractory cardiac arrest treated with ECPR between February 2016 and March 2020. Patients in Hospital Cardiac Arrest are in Hospital Cardiac Arrest, while 37/48 patients are Out of Hospital Cardiac Arrest. For 79. 2% of the patients, the transition from collapse to CPR took less than 5 minutes. 40 and 45 minutes, respectively, were the median CPR duration and abolition to ECMO. The rate of survival was considerably higher in patients with initial shockable rhythm and to whom temperature control post cardiac arrest was applied. Conclusion This is the first comprehensive analysis of ECPR in the middle east region and shows that 20. 8% of patients surviving before hospital discharge was found.
Source link: https://europepmc.org/article/MED/36587751
This research was designed to examine the effects of bystander cardiopulmonary resuscitation and dispatcher-assisted CPR on outcomes after out-of-hospital cardiac arrest. We conducted a prospective observational study using the Korean Cardiac Arrest Research Consortium's registry database and recruited adults aged > 20 years who attended OHCA. All enrolled patients were rushed to the emergency room and revived by emergency medical staff, and emergency personnel were retrieved. In 6. 5%, 9. 9%, and 9. 6% of patients in the "no bystander" and "compression-only bystander" CPR groups, respectively, patients in the no bystander," standardized bystander" and "compression-only bystander" CPR groups, respectively, differed sharply, with significant differences noted. The interaction between 'compression-only' and DA-CPR showed a positive effect on healthy neurological outcomes and survival to discharge in a multivariable model with an odds ratio of 1. 93 and 1. 74, respectively. After OHCA, the relationship between compression-only CPR and DA-CPR is highly associated with improved neurological and survival outcomes.
Source link: https://europepmc.org/article/MED/36575302
The first stage investigated the effectiveness of providing real-time biofeedback using the Q-CPR device on student paramedics' delivery of CPR. Secondly, the study quantified the effects of physical exhaustion on maintaining high quality cardiopulmonary resuscitation performed by paramedic students. Methods Forty Medic students completed cardiopulmonary resuscitation on an instrumented manikin with and without audio-visual biofeedback in a balanced cross-over style. The depth and exhaustion levels increased after using the Q-CPR prompt with biofeedback, highlighting a correlation between correct depth and increased exhaustion, showing a connection between proper depth and increased exhaustion.
Source link: https://europepmc.org/article/MED/36526551
Objects: Objectives: To provide updated systematic review of the use of extracorporeal cardiopulmonary resuscitation during cardiac arrest, compare to manual or mechanical cardiopulmonary resuscitation. Between January 1, 2018, and June 21, 2022, randomized trials and observational studies were conducted for randomized trials and observational studies. Adults and children with out-of-hospital or in-hospital cardiac arrest were among the population. All trials included adults with out-of-hospital cardiac arrest and were terminated before enrolling the intended number of individuals. One trial found a benefit of ECPR in longevity and improved neurological health, as well as good neurological health, despite two trials finding no statistically significant differences in outcomes. There were 23 observational studies in adults with out-of-hospital cardiac arrest or in combination with in-hospital cardiac arrest, as well as in-hospital cardiac arrest, and 4 observational studies in children with in-hospital cardiac arrest. It is uncertain which patients would benefit from ECPR.
Source link: https://europepmc.org/article/MED/36521684
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