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Aims: Congestive heart failure can be triggered by a severe cardiovascular disease or acute myocardial infarction. Postn was also present in the infarct border of human and mouse hearts with AMI. Methods and findings The expression of Postn in AMI mice and hypoxia-treated neonatal mouse cardiomyocytes was quantified by qRT-PCR. Trypan blue, TUNEL, flow cytometry analysis, and JC-1 assays investigated Postn's AMI's biological functions. Postn demonstrated an increase-regulated expression in AMI mice and hypoxia-treated NMCMs. Cellular apoptosis in NMCMs was promoted by hypoxia treatment, according to functional assays. Cells in hypoxia-induced NMCMs could be able to reduce cell apoptosis in hypoxia-induced NMCMs, according to the And Postn shortage. In a RNA-induced silencing complex, Postn and miR-203-3p were found to coexist with small nucleolar RNA host gene 8. In addition, vascular endothelial growth factor A was discovered to bind to miR-203-3p and be implicated in Snhg8-mediated AML cell apoptosis and angiogenesis.
Source link: https://europepmc.org/article/MED/35104050
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