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Cardiomyocytes apoptosis hypoxia - Crossref

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Last Updated: 23 January 2022

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miR-20b-5p attenuates hypoxia-induced apoptosis in cardiomyocytes via the HIF-1α/NF-κB pathway

In H9c2 cells under low oxygen conditions, the expression of miR-20b-5p was downregulated, according to the studies. In H9c2 cells transfected with HIF-1 plasmids, HIF-1 overexpression has been down-regulated further. In addition, HIF-1 overexpression in H9c2 cells transfected with HIF-1 plasmids. In addition, Annexin-V-FITC/PI flow cytometry results suggested that overexpression of miR-20b-5p attenuated cell apoptosis in H9c2 cells under hypoxia condition. The hypoxia had increased Bax and cleaved-caspase-3, according to an H9c2 cell analysis, but decreased Bcl-2 expression, indicating that hypoxia-mediated NF-B signaling pathway activation is mediated by miR-20b-5p. Following HIF-1's death, hypoxia-induced H9c2 cell apoptosis was reduced, according to the flow cytometry results.

Source link: https://doi.org/10.1093/abbs/gmaa056

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions