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Cardiomyocytes Apoptosis - Springer Nature

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Last Updated: 13 July 2022

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Sox9 Promotes Cardiomyocyte Apoptosis After Acute Myocardial Infarction by Promoting miR-223-3p and Inhibiting MEF2C

The effect of transcription factors on AMI is being investigated more deeply. After AMI, our research is looking at the role of Sox9 in cardiomyocyte apoptosis. By hypoxia therapy, an AMI cell model was established in AC16 cells. The association between Sox9 and miR-223-3p and MEF2C was established, as well as between miR-223-3p and MEF2C. The expression of miR-223-3p was restricted using the miR-223-3p mimic, and joint experiments were carried out as si-Sox9 or si-MEF2C was transfected into cells to block the expression of Sox9 or MEF2C. MEF2C is a phenomic. Overexpression and MEF2C silencing in hypoxia-treated cardiomyocyte apoptosis may be able to counteract Sox9's suppressive role in hypoxia-treated cardiomyocyte apoptosis.

Source link: https://doi.org/10.1007/s12033-022-00471-7


Ginsenoside Rg2 Attenuates Doxorubicin-induced Cardiomyocyte Apoptosis via the PI3K/Akt Pathway

Ginsenoside Rg2 is extracted from Panax ginseng C. A. Mey. , Araliaceae, and is believed to have cardioprotective properties. However, to date, there have been no reports on whether ginsenoside Rg2 could shield cardiomyocytes against doxorubicin. Although LY294002 prevented heartbeat apoptosis induced by doxorubicin in a dose-dependent manner, Ginsenoside Rg2 in a dose-dependent manner, this effect was blocked by LY294002. Moreover, ginsenoside Rg2 regulated protein kinase B phosphorylation by the phosphatidylinositol 3-kinase B pathway and reduced p53 expression, according to Rg2. These results suggest that ginsenoside Rg2 can reduce doxorubicin-induced cardiomyocyte apoptosis by the phosphatidylikinase/protein kinase B pathway.

Source link: https://doi.org/10.1007/s43450-022-00261-x


Long Noncoding RNAs Involved in Cardiomyocyte Apoptosis Triggered by Different Stressors

Understanding the molecular mechanisms that control cardiomyocyte apoptosis is of utmost importance in the prevention and treatment of cardiovascular diseases. Long noncoding RNAs play significant regulatory roles in myocardial cell apoptosis, according to increasing evidence in recent years. In addition, reverseing the abnormal lncRNA expression can attenuate and even reverse cardiomyocyte pathological apoptosis. Also, apoptosis-related lncRNAs may be a potential new field for investigating cardiomyocyte apoptosis and providing new guidelines for cardiovascular disease treatment.

Source link: https://doi.org/10.1007/s12265-021-10186-w

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions