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Cardiomyocytes Apoptosis - Springer Nature

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Last Updated: 12 January 2023

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Xinyang Tablet attenuates chronic hypoxia-induced right ventricular remodeling via inhibiting cardiomyocytes apoptosis

Hypoxia-induced pulmonary hypertension is one of the most common pathologies associated with hypobaric hypoxia that leads to right ventricular remodeling and RV failure. The incidence of RV failure caused by HPH is high in rural areas, and there are no approved drugs. However, the effects of XYT on chronic hypoxia-induced RV failure are not clear, but the effects of XYT on chronic hypoxia-induced RV failure are not clear. To obtain the RV remodeling model, the Springville rats were housed in a hypobaric chamber for 21 days. TNF-u03b1, IL-6, Bax, Bcl-2, and caspase-3 were found in the RV and H9c2 cells by western blot. XYT protected H9c2 cells against Cobalt chloride-induced apoptosis in a H9c2 myocardial hypoxia model. Conclusions We concluded that XYT improved hypoxia-induced RV remodeling and protection against cardiac arrest by blocking the apoptosis pathway in vivo and vitro models, which may be a promising therapeutic strategy in clinical care of hypoxia-induced cardiac injury.

Source link: https://doi.org/10.1186/s13020-022-00689-2


Combined Transplantation of Human MSCs and ECFCs Improves Cardiac Function and Decrease Cardiomyocyte Apoptosis After Acute Myocardial Infarction

Background Ischemic heart disease, often triggered by acute myocardial infarction, is one of the most common causes of morbidity and mortality worldwide. Despite significant strides in medical and surgical procedures, millions of AMI patients continue to experience heart disease every year. Methods In a pre-clinical model of acute myocardial infarction, we investigated the combination of human mesenchymal stromal cells and endothelial colony-forming cells to reduce early ischemic injury and increase angiogenesis. Mice were exposed to AMI and transplantation of MSCs and ECFCs either alone or in combination. In short- and long-term follow-up studies, cardiomyocyte apoptosis and cardiac functional recovery were assessed. AMI, MSC-, and ECFC-treated animals had significantly lower cardiomyocyte apoptosis in comparison to vehicle-treated animals. These findings support the use of this combined cell therapy approach in future human studies during the acute phase of ischemic heart disease.

Source link: https://doi.org/10.1007/s12015-022-10468-z

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions