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Cardinal - Europe PMC

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Last Updated: 27 July 2022

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Patient Experience in Early-Stage Parkinson's Disease: Using a Mixed Methods Analysis to Identify Which Concepts Are Cardinal for Clinical Trial Outcome Assessment.

It is increasingly accepted that clinical outcome assessments used in trials do not adequately reflect the variety of symptoms/impacts that are relevant to people with early-stage PD. We sought to conceptualize the patient experience in early-stage PD and identify, from the patient's perspective, those cardinal signs/impacts that may be more useful to monitor in clinical trials. Patient experience of early-stage PD was explored and created by a conceptual model. "Functional stuggesty" was found to be more relevant than "difficulty" to patients with early-stage PD, who often reported being slower at finishing tasks rather than experiencing significant impairment with task completion. Patient experiences in early-stage PD are varied and diverse, and commercially available patient-reported outcome systems do not properly assess several early-stage PD measures, such as functional slowedness, fine motor skills, and subtle gait abnormalities.

Source link: https://europepmc.org/article/MED/35778541


EEG analysis and classification based on cardinal spline empirical mode decomposition and synchrony features.

This paper discusses the development of EEG processing with the use of cardinal spline empirical mode decomposition. This latest method converts EEG signals into discrete components separated by a different signal envelope interpolation algorithm, resulting in improved signal decomposition stability and improved signal decomposition characteristics than classical empirical mode decomposition. Using a support vector machine, the IMFs obtained from the new method are then used to determine longitudinal and transversal synchrony measurements, which are then used to determine longitudinal and transversal synchrony metrics, which are then used to calculate longitudinal and transversal synchrony statistics, which are used as tools for healthy and dementia classification. The findings show that using multiple synchrony measures of both longitudinal and transversal EEG channels on five IMFs provides the highest classification result of 90 percent precision, 96. 67% sensitivity, 83. 3 percent sensitivity, and 96. 1 percent precision, outperforming the conventional EMG method and several other approaches. CS-EMD may also be used in processing other nonlinear and nonstationary biosignals.

Source link: https://europepmc.org/article/MED/35760949


An evaluation of the three measurable cardinal objectives of the National Youth Service Corps programme: a survey dataset

The National Youth Service Corps project, among other objectives, aims at increasing national recognition and compassion in a culturally heterogeneous society. The NYSC program, as well as other public services, needs to be evaluated for accuracy, accountability, and decision making. This database was gathered from N. . . . ian graduates who completed their national service between 2012 and 2021. The data was collected through an electronic poll sent to many online platforms hosting National Youth Service Corps members of the various sets and batches. The data collection was designed to assess the programme's three cardinal objectives. The database is broad and includes all of N. . . . ia's 36 states as well as the Federal Capital Territory. The data set contains details on camp operations, primary duties, and community service involvements of corps members, which could be used to many reuse scenarios.

Source link: https://europepmc.org/article/PPR/PPR505624

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions