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Cardiac Systolic Dysfunction - Crossref

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Last Updated: 03 May 2022

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DeepStrain Evidence of Asymptomatic Left Ventricular Diastolic and Systolic Dysfunction in Young Adults With Cardiac Risk Factors

Purpose: Objectives To determine if a fully automated deep learning system for myocardial strain analysis based on magnetic resonance imaging cine images could reveal asymptomatic distress in young adults with heart risk factors. Both groups showed signs of asymptomatic left ventricular diastolic and systolic dysfunction, as shown by a reduced circumferential strain rate and lower septal circumferential strain relative to controls. Body surface area correlated negatively with all strain tests, according to all strain tests, and mean arterial pressure correlated negatively with early-diastolic strain rate. Conclusions DeepStrain compiled concrete evidence of asymptomatic left ventricular diastolic and systolic dysfunction in asymptomatic young adults with obesity, hypertension, and type 2 diabetes risk factors.

Source link: https://doi.org/10.3389/fcvm.2022.831080


Abstract 283: Western Diet Induces Diastolic Dysfunction Linked to Impaired Cardiac Lipid Storage Dynamics That Predate Systolic Dysfunction

However, the mechanisms relating WD to cardiomyopathy are yet to be understood. We hypothesize that WD causes cardiac dysfunction by dysregulation of cardiac lipid balances, which leads to cardiac dysfunction. With no change in the TG synthase, DGAT1, decreased TG lipase, not TAG synthesis, lower TG lipase, ATGL, lower TG lipase, ATGL, and lower TG turnover, the TG lipase, suggesting increased cardiac TG and lower TG turnover are due to reduced TG hydrolysis and not TAG synthesis, we TD induced lower TG lipase, ATGL TG lipa TG lipase TG synthase, TG synthase, TG lipase, synthesis, rather TAG synthesis, ATGL TG lipase, synthesis, ATGL synthesis, graft TAG graft synthesis. Despite reduced CPT1b in WD hearts, contributions from LCFAs to acetyl CoA production in the citric acid cycle remained unchanged, implying that the WD had sufficient LCFAs for mitochondrial oxidation and that reduced CPT1b was not restricting. In conclusion, the western diet raises the TG pool but affects fat storage capacity by low ATGL, contributing to early diastolic dysfunction and eventual systolic dysfunction.

Source link: https://doi.org/10.1161/res.127.suppl_1.283


Abstract 91: Cardiac-directed Expression of Adenylyl Cyclase Catalytic Domain Reduces Left Ventricular Systolic and Diastolic Dysfunction in Pressure-overload

Moreover, prolonged isoproterenol infusion reduces LV function in normal mice, but C1C2 mice, on the other hand, demonstrate enhanced LV function after sustained Iso infusion. Methods: Transaortic constriction in C1C2 mice and transgene negative mice increased LV pressure overload. Ca2+ treatment was evaluated in isolated cardiac myocytes three weeks after TAC, LV systolic, and diastolic function were determined. C1C2 expression reduced LV hypertrophy, increased LV peak pressure formation, and enhanced LV peak pressure decay in the pressure-overload condition, according to the authors. The peak Ca2+ concentration in cardiac myocytes isolated from pressure-overloaded hearts was raised, and time to peak Ca2+ transient and Tau were reduced. Results: C1C2 expression by Cardiac increases LV hypertrophy, improves Ca2+ handling, and increases LV systolic and diastolic function in pressure-overload. These results support the search for more investigation into C1C2 gene transfer as a potential heart disease cure.

Source link: https://doi.org/10.1161/res.121.suppl_1.91


Abstract 204: Loss Of Akt Caused Aging-induced Cardiac Systolic Dysfunction But Is Independent From Comorbid Diastolic Dysfunction In Aging.

We therefore investigated whether EX could relieve cardiac dysfunction in aging and the role of Akt in the EX-induced changes on the aging heart. To clarify the role of Akt in aging-related heart changes, an analysis of old Akt knockout mice was performed. To elucidate the role of Akt in aging-induced changes in heart. Results: At baseline, R1 strain's cardiac geometry was normal, but the P10 strain had reduced LV wall thickness and DD, in comparison to the P10 strain. R1 mice's body and heart weight were elevated after EX, but the body and heart weight of R1 mice had no effect on P10's BW and HW. P10-EX's s-LVF was also affected by EX, with EF 69. 5 vs. 74. 31. 2 for P10-ctl], whereas P10-Ctl's underlying DD of P10-EX unaffected by EX. Conclusions: Our analysis shows that #1 Akt is crucial for adaptive response to EX, the #2 aging impairs Akt signaling in the heart, contributing to systolic dysfunction, and that #3 Akt is unrelated to modulation of cardiac DD caused by aging.

Source link: https://doi.org/10.1161/res.113.suppl_1.a204


Abstract 178: Exercise Augments Cardiac Akt Activity And Reverses Aging-related Systolic Dysfunction.

A sustained exercise improves HF, according to clinical results; however, the underlying molecular mechanism underlying the aging-related LV remodeling and contractility remains unclear, and no evidence has shown that EX can be helpful for the aging-related LV remodeling and contractility. Because preclinical studies show the pivotal role of protein kinase Akt in aging, we therefore hypothesized that EX might have health-related HF changes induced by ageing, in which Akt may play a vital role. To clarify the role of Akt in the aging heart, age- and gender-matched Akt knockout mice were also enrolled.

Source link: https://doi.org/10.1161/res.115.suppl_1.178

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions