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Cardiac diastolic dysfunction refers to a condition in which irregularities in mechanical function exist during diastole and is an independent forecaster of mortality, even in patients with preserved left ventricular systolic function. Medical symptoms of cardiac diastolic disorder are additionally variable, from asymptomatic subclinical cardiac arrest to heart failing with maintained ejection fraction, angina or workout intolerance without significant epicardial coronary artery condition, or end-stage cardiac arrest. Previous studies provided CMD might be among the major root causes of angina without significant epicardial coronary artery condition and an independent forecaster of damaging medical events in patients with steady ischemic heart condition, acute myocardial infarction, or myocardial condition. Nonetheless, there has been limited research study which evaluated the organization in between cardiac diastolic dysfunction and CMD making use of intrusive physiologic indices and their prognostic effects, specifically in non-MI patients without considerable coronary artery stenosis.
Source link: https://clinicaltrials.gov/ct2/show/NCT05058833
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