Cardiac Transthyretin - Springer Nature

Does [99mTc]-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) soft tissue uptake allow the identification of patients with the diagnosis of cardiac transthyretin-related (ATTR) amyloidosis with higher risk for polyneuropathy?

Fifty patients with cATTR who underwent both planar whole-body DPD scintigraphy and nerve conduction studies were retrospectively assessed. The Perugini score soared in patients with cATTR and additional PNP diagnosis of PNP relative to patients without cATTR and additional diagnosis of PNP. When compared to patients without a prescription, quantitative SPECT/CT revealed that DPD uptake in the subcutaneous fat of the left axillar region was markedly elevated in cATTR patients. Conclusions DPD bone scintigraphy is a useful tool for identifying patients with cATTR and a risk for PNP as a result of increased DPD soft tissue uptake, according to this research.

Source link: https://doi.org/10.1007/s12350-022-02986-7

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