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We aimed to determine the long-term prognostic value of galectin-3 and RV function parameters for all-cause mortality in HF patients treated with cardiac resynchronization therapy. We prospectively followed 63 symptomatic HF patients with a left ventricular ejection fraction of 35%. Patients with high baseline galectin-3 concentrations and a lack of response to CRT showed a significantly reduced chance of surviving, according to an analysis of subgroups defined by galectin-3 concentration and CRT response. The baseline galectin-3 concentration and RV function were independent predictors of long-term all-cause mortality in HFrEF patients following CRT implantation.
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