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Cardiac Nerve - Europe PMC

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Last Updated: 10 September 2022

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Cardiac Autonomic Nerve Dysfunction Predicts Incident Retinopathy and Early Kidney Dysfunction in Adolescents With Type 1 Diabetes.

Objective Cardiac autonomic neuropathy can cause vascular complications in diabetes. We hypothesized that adolescents with CANs are at a higher risk of diabetic retinopathy and early kidney disease. In this prospective longitudinal study of 725 adolescents with type 1 diabetes without retinopathy and albuminuria at baseline, early CAN was identified as one or two abnormalities in seven heart rate tests derived from a 10-minute electrocardiogram. To determine the correlation between CAN and retinopathy or early kidney disease, multivariable generalized estimation equations were used. Results At baseline, the mean age of the sample was 13. 6 years, 52% male, and mean diabetes duration was 3. 3 years, with 52% being male. Conclusions CAN predicted event retinopathy and kidney dysfunction in adolescents with type 1 diabetes, possibly reflecting autonomic microvascular dysregulation contributing to complications.

Source link: https://europepmc.org/article/MED/35997303

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions