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Cardiac Myosin Phosphorylation - Crossref

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Last Updated: 16 August 2022

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Phosphorylation of myosin in permeabilized mammalian cardiac and skeletal muscle cells

In rabbit psoas and ventricular muscle, the effect of myosin phosphorylation on tension production at less than 50% maximum activation by Ca2+ was investigated. Light chain phosphorylation increased from 5-10 to 60-7 percent after the fibers were incubated at pCa 5. 4, resulting in a rise in light chain phosphorylation from 5-10 to 60-75%. Both permeabilized cardiac and skeletal muscle fibers were strained by the increased tension in P-light chain Phosphorylation. P-light chain phosphorylation leads to actin-myosin interactions in cardiac and skeletal muscles at sub-optimal levels of Ca2+ activation, according to these findings.

Source link: https://doi.org/10.1152/ajpcell.1986.250.4.c657

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions