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Cardiac Myosin Light Chain - Crossref

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Last Updated: 16 August 2022

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Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle

The aim of this research was to determine myosin light chain kinase expression in cardiac and skeletal muscle. The only true MLCK detected in cardiac tissue, purified cardiac myocytes, and in a cardiac myocyte cell line was identical to the 130-kDa smooth muscle MLCK. Despite the fact that the 130-kDa smMLCK is present in all adult tissues, including skeletal and cardiac muscle, demonstrates that although the 130-kDa smMLCK is not a smooth muscle-specific protein, it is not a smooth muscle-specific protein.

Source link: https://doi.org/10.1152/ajpcell.2000.279.5.c1656


Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice

More than 40 mutations in the cardiac myosin heavy chain gene and several others in the two myosin light chains cause a dominantly inherited heart disease called familial hypertrophic cardiomyopathy. We tested the likelihood that such a mutant MHC would be a common mutation in cardiac muscle, and not its catalytic function, because the removal of the light chain binding domain in MHC's lever arm of MHC could alter myosin's force transmission but not necessarily its catalytic function. After flash photolysis of diazo 2, skinned myocytes and multicellular preparations from transgenic hearts displayed reduced Ca 2+ sensitivity and reduced relaxation rates, as well as reduced relaxation rates.

Source link: https://doi.org/10.1152/ajpheart.1999.276.6.h2148

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions