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Drug levels in peripheral blood are often used to determine whether death was caused by opioid intoxication. Because peripheral blood is not available, alternative matrix drug concentration ratios and correlations of blood and alternative matrix drug concentrations were determined to determine which of the investigated alternative matrices were most suitable for toxicological testing. Concentrations of cardiac blood, brain tissue, and muscle tissue could be helpful in the postmortem analysis of the majority of the 19 selected analytes, according to the researchers. The median concentration ratios for the selected analytes in brain tissue, cardiac blood, and muscle tissue relative to femoral blood varied from 0. 57 to 1. 87, and 0. 67 to 7. 04, respectively, from 0. 57 to 7. 04, respectively. Overall, cardiac blood samples were the most similar to femoral blood concentrations, indicating that cardiac blood can be useful in situations where femoral blood is not readily available.
Source link: https://europepmc.org/article/MED/36611280
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