Cardiac Muscle Function - Europe PMC

Transplantation of Skeletal Muscle-Derived Sca-1 + /PW1 + /Pax7 - Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction.

Here, we investigated the regenerative potential of PICs after intramyocardial transplantation in mice subjected to an acute myocardial infarction. In the MI-PICs group, a significant rise in ejection fraction and fractional shortening was observed, compared to the MI+ PBS group at 6-weeks post MI + PICs transplantation. The Infarct size/fibrosis of the left ventricle's left ventricle's left ventricle's left ventricle's reduced in the MI-PICs group dramatically, relative to the MI-PBS group. In the MI-PICs group, the cardiomyocyte hypertrophy in the border zone significantly decreased, as did cardiomyocyte apoptosis, as did cardiomyocyte apoptosis. In the MI-PICs' infarct/border zone, the number of BrdU+ cardiomyocytes was significantly increased, relative to the MI-PBS group. PICs can be extracted from skeletal muscle and therefore show promise as a potential cell substitute for cell therapy's reparative and regenerative effects.

Source link: https://europepmc.org/article/MED/36552813

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