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"By combining genetic marker-independence lineage-tracing techniques with transcriptional profiling and loss-of-function tools, we conclude here that the epicardium of the highly regenerative salamander species Pleurodeles waltl has an inherent ability to distinguish into cardiomyocytes. Salamanders are the evolutionarily closest species to mammals with a high ability to regenerate heart muscle, and our findings highlight the epicardium and tight junctions as primary targets in efforts to encourage cardiac regeneration.
Source link: https://doi.org/10.1038/s41556-022-00902-2
"Significance": Since suffering the injury, the human heart is unable to recover properly lost cardiac muscle. Heart failure can be reversed or prevented by replacing missing or dysfunctional cardiac tissue. This research identifies Vegfa as a growth factor capable of initiating genetic programs for heart regeneration and has generalizable implications for cardiac growth factors therapeutic therapy.
Source link: https://doi.org/10.1073/pnas.1722594115
A subset of genes that were up-regulated until 30 or 180 days postnatally and then down-regulated in psoas main muscle was highly enriched in mitochondrial-related steps, while genes that up-regulated in longissimus doris muscle were significantly improved in glycolysis-related processes. In addition, we investigated the relationship between microRNAs and mRNAs in three muscle groups during various stages of growth, uncovering numerous potential microRNA-u2013mRNA pairs involved in regulating glucose metabolism in three muscle types.
Source link: https://doi.org/10.1080/09168451.2014.915725
"The human heart contains the most important in terms of human health, and the most widely studied. " e00b0, 35000b0, and 25thu00b0 are among the 1632-u00c5 standard repeat's that resulted in axial and azimuthal head perturbations within the 429-u00c5 axial repeat, with rotations between successive 132 u00b0, 148 u00c5-, and 149 c5-spaced crowns of heads close to 60 u00b0, 35, 35 00b0, 35, and 25 b0 00b0 u00b0 u00c5-sin head perturbations u00c5-s axial mu00c5-sin head defu00c5-sin axial repeat, axial u00b0, u00c5-u00c5-spaced crowns of heads close to 60 u00b0, 35 u00b0, 35'u00b0, 25'u00b0, 35, 25u00 On the surface of the myosin filament backbone, we have established the myosin head atomic arrangements within the three crown levels and modelled the morphology of myosin subfragment 2 and the potential locations of the 39 spaced domains of titin and the cardiac isoform of myosin-binding protein-C. In the dephosphorylated relaxed state, the two-headed myosin molecule of vertebrate smooth muscle was obtained with head conformations on all crowns close to the configuration of the two-headed myosin molecule of vertebrate smooth muscle.
Source link: https://doi.org/10.1073/pnas.1212708110
"The quest for neural mechanisms that triggered vertebrate organogenesis has led to a deeper understanding of birth defects. Parts of the heart and craniofacial muscles arise from pharyngeal mesoderm progenitors during embryogenesis. We'll explore in the PM's hierarchical regulatory network of a series of transcription factors exemplified in the PM's heart and craniofacial organogenesis. Genetically, Lhx2 and Tcf21 genetically interact with Tbx1, the main determinant of DiGeorge/velo-facial/22q11. 2 deletion syndrome. We believe that PM-derived cardiogenesis and myogenesis are more network functions rather than personal PM members.
Source link: https://doi.org/10.1073/pnas.1208690109
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