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Both TSA and CBHA greatly modified cardiac chromatin structure that took place concomitantly with normalization of IL-18-induced genetics expression and amelioration of cardiac hypertrophy. The hearts of mice revealed to IL-18+/-TSA or CBHA elicited distinctive gene expression profiles. The hearts of mice treated with IL-18 and/or CBHA evoked 147 differentially shared genes, a third of which were oppositely managed by IL-18 and CBHA. Evidently, both TSA and CBHA triggered a 2- to fourfold induction of phosphatase and tensin homolog expression to neutralize IL-18-induced proinflammatory signaling and cardiac hypertrophy.
Source link: https://doi.org/10.1152/physiolgenomics.00048.2011
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