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Cardiac Hypertrophy Rats - Europe PMC

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Last Updated: 13 May 2022

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Valencene post-treatment exhibits cardioprotection via inhibiting cardiac hypertrophy, oxidative stress, nuclear factor- κB inflammatory pathway, and myocardial infarct size in isoproterenol-induced myocardial infarcted rats; A molecular study.

Myocardial infarction is a common global health issue that is responsible for substantial mortality worldwide. Myocardial infarction is an epidemic worldwide. Therefore, it is also recommended to have a new treatment for MI that has less side effects. Rats were first introduced MI by isoproterenol and then treated with valencene and cardiac sensitive indicators, cardiac hypertrophy, oxidative stress, markers of inflammation, nuclear factor-B inflammatory pathway, and myocardial infarct size was estimated/determined. Isoproterenol has significantly improved serum cardiac diagnostic test results, cardiac hypertrophy, conjugated dienes, indicators of inflammation, pro-inflammatory cytokines, and myocardial infarct size. Moreover, histological analysis of a myocardial infarcted rat's cardiac tissue revealed fragmentation of cardiac muscle fibers, necrosis, and inflammatory cells. By its anti-cardiac hypertrophic, antioxidant, anti-inflammatory, and myocardial infarct size limiting results, rats treated with valencene orally, daily, for two weeks.

Source link: https://europepmc.org/article/MED/35469837


Clitoria ternatea (Linn.) flower extract attenuates vascular dysfunction and cardiac hypertrophy via modulation of Ang II/AT1R/TGF‐β1 cascade in hypertensive rats

In a two-clip rat model, this research investigated the effect of CT flower extract on blood pressure, vascular function, and left ventricular hypertrophy. Hypertensive rats were treated with CT extract in various doses or losartan for four weeks. RESULTS: CT extract reduced blood pressure in a dose-dependent manner, and CT extract at a dose of 300 mg kg-1 was a safe concentration. In 2K1C rats, the serum angiotensin and plasma angiotensin II levels were high, but 2K1C rats' symptoms were reduced by CT extract or losartan therapy. In 2K1C rats treated with CT extract or losartan compared to the untreated group, increases in superoxide production and lipid peroxidation were attenuated. In hypertensive rats that were either CT extract or losartan, the plasma concentration of nitric oxide metabolites was increased.

Source link: https://europepmc.org/article/MED/IND607704362


Preventive effects of (-) epicatechin on tachycardia, cardiac hypertrophy, and nuclear factor- κB inflammatory signaling pathway in isoproterenol-induced myocardial infarcted rats.

Myocardial infarction is a life-threatening disorder. In MI, no studies were done earlier on the effects of epicatechin on tachycardia, cardiac hypertrophy, and inflammation. Hence, the preventive effects of EC on tachycardia, cardiac hypertrophy, and the nuclear factor-B inflammatory pathway in experimental MI were reviewed. This investigation involved four groups of 24 male albino Wistar rats. In isoproterenol-induced myocardial infarcted rats, heart rate, plasma myoglobin, serum cardiac troponin I, heart conjugated dienes, serum high-sensitivity C-reactive protein, and plasma total homocysteine were all elevated. In myocardial infarcted rats, a significant rise in the expressions of heart pro-inflammatory cytokines such as nuclear factor-B, tumor necrosis factor-A, interleukin-1, interleukin-6, and a significant decrease in interleukin-10 revealed by a large increase in the expressions of blood cytokine genes, including nuclear factor-B, tumour necrosis factor-, interleukin-1, interleukin Vitamin C and vitamin E were significantly reduced in the heart by non-enzymatic antioxidant antioxidants such as vitamin C and vitamin E.

Source link: https://europepmc.org/article/MED/35346644


Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress.

Cardiac hypertrophy occurs as a result of elevated thyroid hormone levels, which may contribute to heart failure and is closely related to oxidative stress. The expression of natriuretic peptide in Serum was also reduced by hydrogen treatment. However, hydrogen had no effect on levothyroxine-induced serum troponin I and serum thyroid hormone changes. The levothyroxine-induced rise in cardiac malondialdehyde, 8-hydroxy-2-deoxygenase, and serum hydrogen peroxide concentrations also reduced, as well as increased superoxide dismutase and glutathione peroxide production.

Source link: https://europepmc.org/article/MED/35341785


Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge.

Host responses to elevated altitude are aided by the gut microbiota. We used a rat model of hypobaric hypoxia risk to mimic plateau exposure and examined the gut microbiome, short-chain fatty acids, and bile acids over 28 d, which is mainly triggered by the bacterial families of Prevotellaceae, Porphyromodochemia, and pathological cardiac hypertrophy in hypoxic rats. The gut microbiome was highly correlated with the metabolic abnormalities of SCFAs and BAs in feces, showing an interaction network expansion of the microbiome-metabolome following the hypobaric hypoxia challenge. During the hypobaric hypoxia challenge, our findings reveal insights into longitudinal changes in intestinal microecology. Rats with abnormalities in the gut microbiota and microbial metabolites may have contributed to the development of high-altitude heart disease in rats.

Source link: https://europepmc.org/article/MED/35301705


Ameliorative Role of Fluconazole against Abdominal Aortic Constriction-Induced Cardiac Hypertrophy in Rats.

In human liver microsomes, fluconazole reduces the amount of mid-chain HETEs, hampers human recombinant CYP1B1 production, and shields against angiotensin II-induced cellular hypertrophy in H9c2 cells. The current study sought to clarify the potential cardioprotective effects of fluconazole against cardiac hypertrophy caused by abdominal aortic constriction in rats. Male Sprague-Dawley rats were randomly divided into four groups; sham control rats, fluconazole-treated sham rats, AAC rats, and fluconazole-treated AAC rats were randomly divided into four groups; fluconazole-treated sham rats, AAC rats, and fluconazole-treated AAC rats were randomly divided into four groups; and fluconazole-treated AAC rats. Fluconazole substantially reduced AAC-induced left ventricular hypertrophy in left ventricular mass and wall measurements, according to echocardiography reports, as it slowed AAC-mediated increases in left ventricular mass and wall thickness. Fluconazole protects left ventricular hypertrophy, according to the new report, and it reveals the possibility of fluconazole repurposing as a mid-chain HETEs forming enzymes' barrier for cardiac hypertrophy.

Source link: https://europepmc.org/article/MED/35266922


Evidence based mechanistic role of Chrysin towards protection of cardiac hypertrophy & fibrosis in rats.

Chrysin, a honey flavonoid flavonoid, is well known for its multifarious properties, including anti-oxidant, anti-inflammatory, anti-fibrotic, and anti-apoptotic. In rats, chrysin has been found to have cardio-protective activity against isoproterenol-induced Cardiac Hypertrophy and fibrosis. For 28 days, Acclimatized male albino wistar rats were divided into seven groups: Normal, HC, CHY15+H, CHY30+H, CHY60+H, & CHY60+H, HC, CHY15+H, CHY60+H, CHY60 Thro-inflammatory, anti-inflammatory, antioxidant, and anti-fibrotic pathways could have reversed the ISO-induced cardiac hypertrophy and fibrosis, preventing cardiac hypertrophy and fibrosis by various anti-inflammatory, anti-apoptotic, antioxidant, and auto-fibrotic pathways.

Source link: https://europepmc.org/article/MED/35177130

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions