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Cardiac Hypertrophy Angiotensin - Europe PMC

Summarized by Plex Scholar
Last Updated: 13 August 2022

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Angiotensin receptor-neprilysin inhibitor attenuates cardiac hypertrophy and improves diastolic dysfunction in a mouse model of heart failure with preserved ejection fraction.

We investigated the effect of LCZ696 on HFpEF in transverse aortic constriction mice and compared it to the angiotensin receptor blocker, valsartan. LCZ696 improved cardiac diastolic function in mice with overload-induced diastolic dysfunction, and fibrosis in mice with overload-induced diastolic dysfunction. We found that LCZ696 functions as a potent suppressor of calcium-mediated calcineurin-nuclear modulation pathways as a potential underlying mechanism.

Source link: https://europepmc.org/article/MED/35596518

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions