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Cardiac Diastolic - U.S. Department of Veterans Affairs

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Last Updated: 03 December 2022

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Endothelial Mineralocorticoid Receptor Deletion Prevents Diet-Induced Cardiac Diastolic Dysfunction in Females.

Overnutrition and insulin resistance are two key risk factors for female cardiac diastolic dysfunction. We recently reported that intake of a Western diet high in fat, sucrose, and high fructose corn syrup for 16 weeks resulted in cardiac diastolic dysfunction and aortic stiffening in young female mice, which was largely prevented by mineralocorticoid receptor blockade. And wild-type mice were fed mouse chow or WD for four months. WD feeding resulted in prolonged relaxation time, reduced diastolic septal wall mobility, and increased left ventricular filling pressure in diastolic dysfunction. Hence, our results show that increased endothelial cell mineralocorticoid receptor signaling in female mice is a key factor in the induction of cardiac profibrotic, inflammatory, and growth pathways leading to diastolic dysfunction.

Source link: https://doi.org/10.1161/HYPERTENSIONAHA.115.06015

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions