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Conclusion The purpose of the study was to determine left ventricular end-diastolic diameter in cardiac magnetic resonance as a predictor of left ventricular end-diastolic volume. The study group consisted of 78 patients who underwent 1. 5 T CMR screening. In the 4-chamber scheme, the correlation coefficients between LVEDD measurements made by researcher A and B were 0. 98 for the long axis measurements in the 2-chamber and 3-chamber view, and 0. 99 for measurements made in the short axis and in the long axis. In the 3-chamber view, the lowest LVEDD measurement error was recorded for the short axis measurements and the highest for the long axis measurements. In summary, the measurement performed in the short axis should be regarded as the most appropriate approach to a LVEDD test in CMR, considering the repeatability of measurements and the accuracy of left ventricular growth estimation.
Source link: https://doi.org/10.1038/s41598-022-12359-2
Objective: We set out to determine cell and molecular protagonists important to HFpEF by mapping out the heterogeneity of the cardiac immune response to diastolic dysfunction during diastolic dysfunction. We hypothesized that systemic metabolic disturbances during HFpEF were encouraging cardiac inflammation and fibrosis, according to We hypothesized that HFpEF systemic metabolic disturbances were leading to cardiac inflammation and fibrosis. Myeloid deficiency of Cd36 in live animals prevented diastolic dysfunction and was associated with dampened cardiac inflammation. A splenic hematopoietic niche was discovered in wild-type mice when investigating immune cell sources during HFpEF. Within splenic macrophages, HFpEF-associated risk factors stimulated mitochondrial metabolism, as well as the production of vascular cell adhesion molecule-1 (ViC), the latter of which has been shown to maintain hematopoietic stem cells in the spleen. A high fat in vitro treatment of splenic macrophages was sufficient to produce the expression of Vcam1, which was attributed to mitochondrial reactive oxygen species activation of the transcription factor Spic.
Source link: https://doi.org/10.1161/res.131.suppl_1.gs114
Result: Both db/db and KI-3A mice exhibited slower relaxation at the organ level indicated by elevated E/e's. During biaxial passive stretching, the tissue stiffness at the tissue level increased circumferential stiffness at the tissue level. KI-3A mice are much slower than KI-3D mice in knock-in mice, according to biaxial activation-relaxation experiments of LVFW specimens in knock-in mice. In KI-3A mice relative to KI-3D and WT mice, active force production was significantly enhanced in db/db mice, but it was significantly reduced in KI-3A mice relative to KI-3D and WT mice, according to fiber-level experiments. Conclusions: Although both db/db and KI-3A mice demonstrated LVDD at the organ level, they underwent significant changes at the fiber and tissue fiber levels, suggesting that global statistics should be supplemented by metrics describing the LVDD's ability at the fiber and tissue fiber levels to accurately identify LVDD.
Source link: https://doi.org/10.1161/res.131.suppl_1.p3022
HF AAC LF mice weighed less than HF AAC HF mice after 18 weeks. In HF AAC LF mice, cardiac hypertrophy was reduced and accompanied by reduced SIRT1 expression, increased FOXO1 acetylation, and elevated atrogin-1 expression, relative to HF AAC HF mice. Thus, dieting body weight in obese mice with heart failure is linked to reduced cardiac sensitivity and diastolic function, as well as improvements in both cardiac insulin sensitivity and diastolic function, suggesting that weight loss does not adversely influence heart function in the case of obesity.
Source link: https://doi.org/10.2337/db14-1050
Abstract Background Most pediatric cardiac catheterizations are done under general anesthesia, but no studies have investigated how choosing anesthesia agent can influence hemodynamic results in pediatric patients. Patients requiring percutaneous closure of a patent ductus arteriosus or surveillance endomyocardial biopsy at Monroe Carell Jr. Children's Hospital in Vanderbilt were enrolled. Systolic blood pressure was significantly lower under inhaled anesthesia relative to intravenous anesthesia in comparison to baseline non-invasive blood pressure. Both phases showed that systemic vascular resistance was noticeably lower under inhaled anesthesia, though pulmonary vascular resistance was similar. Following the switch to intravenous anesthesia, left ventricular end diastolic pressures in transplant patients increased, with a positive correlation between the increase observed and the initial LVEDP under inhaled anesthesia. An intravenous anesthesia therapy regimen may more closely reflect the awake, pre-catheterization state compared to inhaled volatile anesthesia.
Source link: https://doi.org/10.21203/rs.3.rs-2086136/v1
Abstract Background: Patients with a low ejection percentage can have a heart arrest due to chronic right-ventricular pacing. There is no information on the effects of diastolic dysfunction in patients with preserved EF who are undergoing permanent pacemaker placement. Methods This multicenter, retrospective review of PPM use in Chonnam, South Korea, included all patients with preserved EF undergoing transvenous PPM treatment for atrioventricular blockage from 2017 to 2019. The DD group had older patients enrolled in the study and had a longer QTc interval than those in normal subjects, and had slower paced QTc intervals. DD and pQRSd were independent predictors of composite outcomes in a Cox proportional regression study. Despite preserved left-ventricular function, patients with DD and RV pacing increased the chance of pacing-related heart failure in patients with DD. Patients with DD should therefore be closely monitored.
Source link: https://doi.org/10.1186/s42444-022-00078-8
Using sevoflurane alone and sevoflurane, combining with transversus abdominopelvic surgery, a transparency block in elderly patients with diastolic dysfunction during anesthesia maintenance was used to determine left ventricular diastolic function during anesthesia maintenance. Methods Thirty-eight patients were divided into two groups in this retrospective review, sevoflurane and sevoflurane combining with TAPB and RSB, according to employing different anesthesia maintenance techniques. Anesthesia hemodynamics stability in the ST group showed a more significant rise in e/a and decreases in a value 1 hour after anesthesia induction hemodynamics stability. Conclusions Weak anesthesia was more effective for safeguarding cardiac diastolic function in elderly patients with diastolic dysfunction undergoing open abdominal and pelvic surgery than sevoflurane alone.
Source link: https://doi.org/10.7717/peerj.9441
Methods and findings The evaluation of endomyocardial biopsies from patients with HFpEF revealed that a decreased cardiac PAR2 levels was correlated with exacerbated DD and elevated myocardial fibrosis. One-year-old PAR2-knockout mice suffered from DD with preserved systolic function, collagen deposition, lysyl oxidase production, collagen cross-linking, endothelial activation, and inflammation, according to In line, 1-year-old PAR2-knockout mice suffered from DD with an elevated age-dependent u03b1-knockout mice suffered with impaired systolic function, endo From cardiac fibroblasts, increased collagen I production from this enhanced TGF-u03b2/PAR1 signalling. PAR2 overexpression in PAR2ko CFs reversed these results. In a metabolic disease model, the intervention with the PAR1 antagonist, vorapaxar, reduced cardiac fibrosis by 44% and reduced inflammation. Patients with elevated blood pressure via FXa inhibitors exhibited reduced circulating markers of fibrosis and DD in comparison to those treated with vitamin K antagonists.
Source link: https://doi.org/10.1093/eurheartj/ehz117
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