Cardiac Autonomic Neuropathy - DOAJ

Accuracy of autonomic symptoms in detection of severe cardiac autonomic neuropathy

The aim was to establish the credibility of autonomic signs in the detection of severe cardiac autonomic neuropathy. In 62 adult patients with type 2 diabetes mellitus and cardiac autonomic neuropathy, this research was conducted in BIRDEM. There was no difference in the frequency of autonomic signs between severe and non-severe cardiac autonomic neuropathy, according to the same. Using clinical measurements as a gold standard, gustatory sweating had the highest degree of specificity and constipation, providing the greatest sensitivity in detection of severe cardiac autonomic neuropathy. Patients with type 2 diabetes and cardiac autonomic neuropathy have autonomic neuropathy, and autonomic neuropathy are common.

Source link: https://doaj.org/article/bf2783f8d0fe4822ad4ad041bc245d0e

Accuracy of autonomic symptoms in detection of severe cardiac autonomic neuropathy

The aim was to establish the validity of autonomic signs in the detection of severe cardiac autonomic neuropathy. This research was conducted in BIRDEM in 62 adult patients with type 2 diabetes mellitus and cardiac autonomic neuropathy in 62 adult patients with type 2 diabetes mellitus and cardiac autonomic neuropathy. There was no difference in the frequency of autonomic signs between severe and non-severe cardiac autonomic neuropathy. When performing clinical trials as the gold standard, gustatory sweating revealed the highest specificity and constipation, which provided the highest sensitivity in the detection of severe cardiac autonomic neuropathy. Patients with type 2 diabetes and cardiac autonomic neuropathy have autonomic neuropathy, which is common in diabetic patients.

Source link: https://doi.org/10.3329/bsmmuj.v15i1.58421

Effects of Baicalin on Diabetic Cardiac Autonomic Neuropathy Mediated by the P2Y12 Receptor in Rat Stellate Ganglia

Background/Aims: Chronic diabetic hyperglycemia can damage many organ systems and cause severe complications. Although diabetic autonomic neuropathy is the leading cause of death among diabetic patients, diabetic cardiovascular autonomic neuropathy is the most common cause of death in diabetic diabetics, diabetic patients', the primary cause of death in diabetic patients is still unclear, no one has been fully described. The results of baicalin on increasing sympathoexcitatory response induced by DCAN via the P2Y12 receptor were examined in our study. In the stellate ganglia of diabetic rats, Baicalin reduced elevated blood pressure and heart rate, increased heart rate variability, and decreased elevated expression levels of P2Y12, IL-121, TNF-u03b2, and Cx43. In diabetic rats, Baicalin also reduced the elevated serum epinephrine and the phosphorylation of p38 mitogen-activated protein kinase. Baicalin reduces sympathetic function by blocking the P2Y12 receptor in stellate ganglia satellite glial cells' to maintain the balance between sympathetic and parasympathetic nerves and relieves DCAN in the rats.

Source link: https://doi.org/10.1159/000488828

Cardiac autonomic neuropathy in type 1 and type 2 diabetes patients

Abstract Background Cardiac autonomic neuropathy in diabetes is one of the leading risk factors for future global and cardiovascular mortality. This research was designed to examine CAN prevalence and compare the results between CAN, the glycaemic control system, cardiovascular risk factors, peripheral neuropathy, retinopathy, and macroangiopathy in patients with type 1 and type 2 diabetes mellitus. Methods One hundred ninety-five diabetic patients were included in this research. Conclusions T2DM and 61. 8% in T1DM patients, respectively, were 39. 1% and 61. 8%. With diabetes duration [1. 62], HbA1c [4. 4], age of patients [1. 84], peripheral neuropathy [31. 6] and IMT [5. 5], the chances of CAN increased with diabetes duration [3. 6]]. Conclusion This research showed that CAN is a more common complication in T1DM. The presence of CAN is solely related to a potentially modifiable cardiovascular risk in T2DM patients, apart from glycaemic surveillance.

Source link: https://doi.org/10.1186/s12883-018-1125-1

Naringin Relieves Diabetic Cardiac Autonomic Neuropathy Mediated by P2Y14 Receptor in Superior Cervical Ganglion

Diabetic cardiac autonomic neuropathy is one of the most common complication related to DM. Satellite glial cells in the superior cervical ganglia have been shown to play an important role in DCAN formation, according to previous reports. In addition, naringin, a common Chinese medicine, could also help to reduce the effects of DCAN. Ferroptosis can be involved in DCAN evolution. In diabetic rats, we discovered that significantly elevated expression levels of P2Y14 and IL-1u03b2, both of which were drastically reduced by therapy with either P2Y14 shRNA or naringin, were significantly reduced relative to those of normal subjects. In the SCG, naringin can effectively eliminate DCAN caused by the P2Y14 receptor of SGCs. In addition, the NRF2/GPX4 pathway involved in ferroptosis may be one of the key DCAN pathways that can be modified by P2Y14-targeted naringin to reduce DCAN progression, which may lead to DCAN progression.

Source link: https://doi.org/10.3389/fphar.2022.873090

A study of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: A Northeast India experience

Aim: To determine the incidence and risk factors for cardiac autonomic neuropathy in type 2 diabetes mellitus patients, as well as other factors. Methodology: We included 100 patients with type 2 DM. Diabetes prevalence was 53. 3 u00b1 10. 37 years, with the mean duration of diabetes being 9. 03 years u00b1 6. 4 years. Patients with CAN were younger, had longer diabetes, elevated creatinine, and a lower estimated glomerular filtration rate relative to patients without CAN. Early CAN was 70%, with definite CAN in 24%, and severe CAN in 21%. Conclusion: CAN is a common microvascular complication in type 2 DM with duration of diabetes, age, and severity of nephropathy as its key determinants.

Source link: https://doi.org/10.4103/ijem.IJEM_336_18

Complexity Analysis in the PR, QT, RR and ST Segments of ECG for Early Assessment of Severity in Cardiac Autonomic Neuropathy

This research has investigated the unethical nature of PR, QT, RR, and ST time segments of ECG signals by determining the fractal dimension of all segments from 20 minute ECG recordings of people with varying degrees of the disease and healthy people. The mean calculated for each ECG time segment to tell between subjects was insufficient for an early diagnosis, but not enough for an early diagnosis. According to a forensic review, the evolution of FD in various time segments of ECG during the recording was the most reliable to determine the steps for severity of CAN-related illnesses in patients with early signs of CAN. According to Feature ranking results, fractal features have more weight than time segments of ECG in differentiating the subjects. The findings of statistical validation show that all the selected features based on ECG physiology demonstrated an obvious complexity change in both normal and severity stages of CAN's standard and severity stages.

Source link: https://doi.org/10.3390/app12115746

Identifying diabetic patients with cardiac autonomic neuropathy by heart rate complexity analysis

Abstract Background Cardiac autonomic neuropathy in diabetes has been dubbed a "silent killer" by so few patients that they suffer from it, yet, its effect can be lethal, as shown by the above. Methods of Analysis The ECG recordings during supine rest of 17 sets of ECG recordings were obtained from diabetic patients with CAN and without CAN CAN, as well as analyzed. The classification Trees approach, which generated a simple decision tree for CAN+ prediction, including SampEn and Poincar*u00e9 plot indexes, with a sensitivity of 100 percent and a specificity of 75%.

Source link: https://doi.org/10.1186/1475-925X-8-3

A Comparison of Nonlinear Measures for the Detection of Cardiac Autonomic Neuropathy from Heart Rate Variability

In this research, we compare three multiscale measures for their ability to discriminate between participants with cardiac autonomic neuropathy and age controls. CAN is a disease that causes nerve damage leading to an abnormal heart rate monitoring, so one would expect disease progression to appear in changes to heart rate variability.

Source link: https://doi.org/10.3390/e17031425

Effect of ramipril/hydrochlorothiazide and ramipril/canrenone combination on atrial fibrillation recurrence in hypertensive type 2 diabetic patients with and without cardiac autonomic neuropathy

A total of 289 hypertensive type 2 diabetic patients, 95 with CAN, are in sinus rhythm, but there have been at least two episodes of AF in the last 6 months, and they were randomized to ramipril 5 mg plus HCTZ 12. 5 mg or amlodipine 5 mg for 1 year. Before and after each treatment period, collagen type I carboxy-terminal peptide and carboxy-terminal telopeptide of collagen type I were tested. Patients with amlodipine had a recurrence of AF, as did 31% of patients with ramipril/HCTZ and 13% of patients with ramipril/canrenone. These results also showed that ramipril/canrenone therapy in type 2 diabetic hypertensives was more effective than ramipril/HCTZ in reducing AF recurrence.

Source link: https://doi.org/10.5114/aoms.2016.62448

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