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Cardiac Attr - Europe PMC

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Last Updated: 09 November 2022

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THERAPY OF ATTR CARDIAC AMYLOIDOSIS: CURRENT INDICATIONS.

Transthyretin cardiac amyloidosis is a restrictive cardiomyopathy characterized by extracellular deposition in the center of amyloid fibrils derived from plasma transthyretin derived from plasma transthyretin derived from plasma transthyretin, whether in its hereditary or acquired forms. If therapy is not started promptly, Cardiac amyloidosis has a very poor prognosis. To reduce symptoms, CV hospitalization, and mortality, Tafamidis is advised to treat patients with genetic testing that demonstrates hereditary hTTR-cardiomyopathy or wild-type TTR cardiomyopathy or wild-type TTR cardiomyopathy or wild-type TTR cardiomyopathy or wild-type TTR cardiomyopathy. Patisiran should be considered in ATTRh cardiomyopathy with polyneuropathy with polyneuropathy.

Source link: https://europepmc.org/article/MED/36336119


Impact of Earlier Diagnosis in Cardiac ATTR Amyloidosis Over the Course of 20 Years.

Methods This is a retrospective observational cohort study of all patients referred to the National Amyloidosis Centre, in whom ATTR-CA was a differential diagnosis. Results We found 2995 patients referred to alleged ATTR-CA, of whom 1967 had a diagnosis of ATTR-CA. During the five-year intervals, the median duration of associated symptoms before diagnosis decreased from 36 months between 2002 and 2006 to 12 months between 2017 and 2021, and a greater number of patients had early-stage disease at diagnosis across the 5-year intervals. The number of patients accepted into clinical trials and prescribed disease-modifying therapy increased over the 20-year course, but even when censoring was applied at the trial or medication start date, the year of diagnosis remained a significant predictor of mortality. Conclusions There has been a significant rise in ATTR-CA diagnoses, with more patients being referred after local advanced cardiac imaging.

Source link: https://europepmc.org/article/MED/36325894

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions